Research on De-Noising Method of Grounded Electrical Source Airborne Transient Electromagnetic Data Based on Singular Spectrum Analysis

The grounded electrical source airborne transient electromagnetic (GREATEM) system is widely used in groundwater resources detection, geothermal resource detection, geological structure detection, and other fields due to its wide detection range, high detection efficiency, and high resolution. The field data received by the GREATEM system is easily affected by various noises, such as instrument system noise, power frequency noise, sferics noise, and other noise, which reduce the data signal-to-noise ratio (SNR) and affects the data interpretation accuracy. This paper proposes a singular spectrum analysis (SSA) for the GREATEM data de-noising in response to this problem. First, we calculate the electromagnetic response of a uniform half-space using a GREATEM system with an electrical source to verify the effectiveness of the SSA algorithm for GREATEM data de-noising. To determine the appropriate parameters for SSA, we propose a particle swarm optimization algorithm to choose the window length. Later, SSA is used to decompose a synthetic quasi-two-dimensional earth model of GREATEM data. After SSA, the SNR of the reconstructed signal increased by 36 dB, and the RMSE does not exceed 4.9 × 10−6, which verifies the feasibility of the SSA for de-noising GREATEM data. Finally, through field measurement data processing, the effectiveness of the method is further confirmed

N-Acetylglucosamine mitigates lung injury and pulmonary fibrosis induced by bleomycin

Lung injury and pulmonary fibrosis contribute to morbidity and mortality, and, in particular, are characterized as leading cause on confirmed COVID-19 death. To date, efficient therapeutic approach for such lung diseases is lacking. N-Acetylglucosamine (NAG), an acetylated derivative of glucosamine, has been proposed as a potential protector of lung function in several types of lung diseases. The mechanism by which NAG protects against lung injury, however, remains unclear. Here, we show that NAG treatment improves pulmonary function in bleomycin (BLM)-induced lung injury model measured by flexiVent system. At early phase of lung injury, NAG treatment results in silenced immune response by targeting ARG1+ macrophages activation, and, consequently, blocks KRT8+ transitional stem cell in the alveolar region to stimulate PDGF Rβ+ fibroblasts hyperproliferation, thereby attenuating the pulmonary fibrosis. This combinational depression of immune response and extracellular matrix deposition within the lung mitigates lung injury and pulmonary fibrosis induced by BLM. Our findings provide novel insight into the protective role of NAG in lung injury

Measurement of the neutron total cross sections of aluminum at the back-n white neutron source of CSNS

Aluminum and its alloys are widely used in the nuclear industry. Therefore, it is essential to precisely measure and accurately know the neutron total cross section of aluminum in the wider energy region. The measurement is performed by using the transmission method at the Back-n White Neutron Source of CSNS. Two aluminum samples 70 mm in diameter and thicknesses of 40 and 60 mm, respectively, were positioned at 55 m from the neutron source. The transmission detector consisted of a multi-layer fast fission chamber loaded with $$^{235}$$U and $$^{238}$$U, and it was located at the 76-m measurement station. By applying the time-of-flight technique, it was possible to extract the n+$$^{27}$$Al total cross section in a wide energy region, from 1 eV to 20 MeV, after the correction for the double-bunch mode of the CSNS accelerator. The total cross sections obtained with the two Al samples are consistent and the results obtained with the $$^{235}$$U fission cells are in good agreement with that with $$^{238}$$U in the energy range of 1–20 MeV. The uncertainty of neutron total cross section measured with $$^{235}$$U for 40 mm and 60 mm thick aluminum is 0.7–22.3% and 0.6–12.4% in the energy range of 10 keV–20 MeV. Results are in fair agreement with respect to previous data and evaluations

Neutron energy spectrum measurement of the Back-n white neutron source at CSNS

China Spallation Neutron Source (CSNS) has been built and commissioned successfully in 2018 which is implemented by impinging 1.6 GeV protons onto a tungsten target with 25 Hz repetition frequency. An associated white neutron beam line exploiting the back-streaming neutrons, named Back-n, with a flight path of 55 m in endstation 1 (#ES1) and 76 m in endstation 2 (#ES2) was built mainly for nuclear data measurements. The Back-n beam line started running since the beginning of 2018 and the neutron energy spectrum was measured at the very beginning since it is an essential information for feasibility study and analysis of any measurement. In this paper, the measurement of the neutron energy spectrum of Back-n #ES2 is reported. The first result of the neutron flux from 1 eV to 100 MeV measured by a fission chamber based on the 235U(n, f) reaction is presented. The total neutron flux normalized to the proton beam power of 100 kW is $7.03 \times 10^{6}$ neutrons/cm2/s. The results show a good agreement with that of the Monte Carlo simulation as well