Orbital Angular Momentum Waves: Generation, Detection and Emerging Applications

Orbital angular momentum (OAM) has aroused a widespread interest in many fields, especially in telecommunications due to its potential for unleashing new capacity in the severely congested spectrum of commercial communication systems. Beams carrying OAM have a helical phase front and a field strength with a singularity along the axial center, which can be used for information transmission, imaging and particle manipulation. The number of orthogonal OAM modes in a single beam is theoretically infinite and each mode is an element of a complete orthogonal basis that can be employed for multiplexing different signals, thus greatly improving the spectrum efficiency. In this paper, we comprehensively summarize and compare the methods for generation and detection of optical OAM, radio OAM and acoustic OAM. Then, we represent the applications and technical challenges of OAM in communications, including free-space optical communications, optical fiber communications, radio communications and acoustic communications. To complete our survey, we also discuss the state of art of particle manipulation and target imaging with OAM beams

Polyetheretherketone Cages Alone with Allograft for Three-Level Anterior Cervical Fusion

A total of 25 consecutive patients suffering from degenerative cervical disc disease who underwent three-level anterior cervical discectomy and fusion (ACDF) including polyetheretherketone (PEEK) cages packed with allograft were followed up for at least two years. The fusion rate reached 72% (18/25), and asymptomatic pseudarthrosis was seen in 6 patients but without mobility on flexion-extension radiographs, and revision surgery was not needed. Cage subsidence occurred at one level (C67), but it was not progressive, and reoperation was not necessary. A significant increase (P < 0.001) in fused segment angle (FSA) and fused segment height (FSH) was observed postoperatively. Similarly, a significant clinical improvement (P < 0.001) was demonstrated postoperatively in terms of Japanese Orthopedic Association (JOA) score and visual analog scales (VASs) score. PEEK cages alone with allograft proved to be a safe and effective surgical option in the treatment of three-level degenerative cervical disc disease. Although the fusion rate was not high, this technique may offer improvement of symptomatology and maintenance of cervical spine's sagittal profile

Clinicopathological Research and Expression of PTEN/PI3K/Akt Signaling Pathway in Non-small Cell Lung Cancer

Background and objective It has been known that abnormality of PTEN/PI3K/Akt signal pathway played an important role in initiation of some malignant tumors. The aim of this study is to examine the expression and clinicopathological significance of PTEN, PI3K and Akt in non-small cell lung cancer (NSCLC). Methods Expression levels of PTEN, PI3K and Akt protein were determined using immunohistochemistry S-P in 61 specimens of NSCLC with follow-up. Results ①The levels of PTEN protein was higher than that of control group, and levels of PI3K and Akt protein were lower than that of control group; ②Expression of PTEN and PI3K were related to histotype, clinical stage, lymphonode metastasis and survival rate; Expression of Akt was related to clinical stage, lymphonode metastasis and survival rate; ③The Cox Monovariable Analyses revealed that both smoking and negative expression of PTEN were the risking factors on the death of the NSCLC patients after surgery; ④The expression of PTEN protein was negatively correlated to that of PI3K and Akt respectively, while the expression of PI3K was positively correlated to that of Akt. Conclusion In NSCLC, the lack of PTEN induced up-regulation of PI3K and Akt, which demonstrated that PTEN/PI3K/Akt signaling pathway contributed to the tumorigenesis and development of NSCLC. They could be used as the indicators of prognosis and targets of therapy

Local hyperthermia decreases the expression of CCL-20 in condyloma acuminatum

<p>Abstract</p> <p>Background</p> <p>Local hyperthermia has been successfully used in the treatment of viral warts. However, the mechanism of action has largely remained unclear. CCL-20 (also known as MIP-3α) is the most potent chemokine for recruitment of Langerhans cell (LC) precursors into the skin. CCL-20 expression can be increased by TNF-α and IL-1α. The effects of local hyperthermia on the mRNA expressions of CCL-20, TNF-α, IL-1α have been investigated in both condyloma acuminata (CA) and normal skin. Under an organotypic culture condition, fresh CA and normal skin were subjected to surface heating at 37°C, 42°C and 45°C for 30 mins, respectively.</p> <p>Results</p> <p>The mRNA expressions of CCL-20 and IL-1α in CA specimen were significantly higher than those in normal skin. Local hyperthermia at 42°C and 45°C significantly decreased the mRNA levels of CCL-20 and IL-1α, as compared with the control groups (p < 0.01). The decrease of CCL-20 was well correlated with that of IL-1α. The expression of TNF-α in CA remained unchanged in spite of the temperature variation. Local hyperthermia at 45°C concomitantly increased the mRNA expression of CCL-20 and IL-1α in normal skin.</p> <p>Conclusions</p> <p>Our study suggests that hyperthermia decreases the expression of CCL-20 with concomitant decrease in IL-1α, and reduce the number of Langerhans cells in HPV infected skin.</p

Simulating and understanding the gap outflow and oceanic response over the Gulf of Tehuantepec during GOTEX

17 USC 105 interim-entered record; under review.Tehuantepecer is a strong mountain gap wind traveling through Chivela Pass into eastern Pacific coastin southern Mexico, most commonly between October and February and brings huge impacts on local and surrounding meteorology and oceanography. Gulf of Tehuantepec EXperiment (GOTEX) was conducted in February 2004 to enhance the understanding of the strong offshore gap wind, ocean cooling, vertical circulations and interactions among them. The gap wind event during GOTEX was simulated using the U.S. Navy Coupled Ocean/Atmosphere Mesoscale Prediction System (COAMPS® ). The simulations are compared and validated with the observations retrieved from several satellites (GOES 10–12, MODIS/Aqua/Terra, TMI, and QuikSCAT) and Airborne EXpendable BathyThermograph (AXBT). The study shows that the gap wind outflow has a fanlike pattern expending from the coast and with a strong diurnal variability. The surface wind stress and cooling along the axis of the gap wind outflow caused intense upwelling and vertical mixing in the upper ocean; both contributed to the cooling of the ocean mixed layer under the gap wind. The cooling pattern of sea surface temperature (SST) also reflects temperature advection by the nearby ocean eddies to have a crescent shape. Two sensitivity experiments were conducted to understand the relative roles of the wind stress and heat flux on the ocean cooling. The control has more cooling right under the gap flow region than either the wind-stress-only or the heat-flux-only experiment. Overall, the wind stress has a slightly larger effect in bringing down the ocean temperature near the surface and plays a more important role in local ocean circulations beneath the mixed layer. The impact of surface heat flux on the ocean is more limited to the top 30 m within the mixed layer and is symmetric to the gap flow region by cooling the ocean under the gap flow region and reducing the warming on both sides. The effect of surface wind stress is to induce more cooling in the mixed layer under the gap wind through upwelling associated with Ekman divergence at the surface. Its effect deeper down is antisymmetric related to the nearby thermocline dome by inducing more upwelling to the east side of the gap flow region and more downwelling on the west side. Diagnostics from the mixed layer heat budget for the control and sensitivity experiments confirm that the surface heat flux has more influence on the broader area and the wind stress has more influence in a deeper region.This research is supported by Office of Naval Research (ONR) through the Department Research Initiative Predictability of Seasonal and Intraseasonal Oscillations (PE061153N). Computational resources were supported in part by a grant of HPC time from the Department of Defense Major Shared Resource Centers, Stennis Space Center, Mississippi

HARQ in Poisson Point Process-based Heterogeneous Networks

Hybrid automatic repeat request (HARQ) plays an important role in improving the transmission efficiency and the robustness of wireless networks. Considering K-tier heterogeneous networks (HetNets) and modelling the locations of the base stations (BSs) as a homogeneous Poisson point process (PPP), this paper investigates the performance of HetNets implementing HARQ. We give closed-form expressions for the coverage probability and the per-user throughput with HARQ and show that using HARQ can indeed improve the coverage probability. However, depending on the channel conditions, the per-user throughput of the HetNets may decrease by the implementation of HARQ. Furthermore, we show that the small cell density has negligible effect on the coverage probability and per-user throughput, and the per-user throughput may increase with the small cell path loss

Spatio-Temporal Dynamics of Global Potential Vegetation Distributions Simulated by CSCS Approach

The study of Potential Natural Vegetation (PNV) has been proposed as a way to examine the impact of changes in climate on the distribution of vegetation. This study analyzes the influence of climate change in the potential vegetation distribution at global scale, using the Comprehensive Sequential Classification System (CSCS) approach to explore the changes of area, shift distance and direction for each broad vegetation category

Comparing the Usefulness of Distance, Monophyly and Character-Based DNA Barcoding Methods in Species Identification: A Case Study of Neogastropoda

DNA barcoding has recently been proposed as a promising tool for the rapid species identification in a wide range of animal taxa. Two broad methods (distance and monophyly-based methods) have been used. One method is based on degree of DNA sequence variation within and between species while another method requires the recovery of species as discrete clades (monophyly) on a phylogenetic tree. Nevertheless, some issues complicate the use of both methods. A recently applied new technique, the character-based DNA barcode method, however, characterizes species through a unique combination of diagnostic characters.Here we analyzed 108 COI and 102 16S rDNA sequences of 40 species of Neogastropoda from a wide phylogenetic range to assess the performance of distance, monophyly and character-based methods of DNA barcoding. The distance-based method for both COI and 16S rDNA genes performed poorly in terms of species identification. Obvious overlap between intraspecific and interspecific divergences for both genes was found. The “10× rule” threshold resulted in lumping about half of distinct species for both genes. The neighbour-joining phylogenetic tree of COI could distinguish all species studied. However, the 16S rDNA tree could not distinguish some closely related species. In contrast, the character-based barcode method for both genes successfully identified 100% of the neogastropod species included, and performed well in discriminating neogastropod genera.This present study demonstrates the effectiveness of the character-based barcoding method for species identification in different taxonomic levels, especially for discriminating the closely related species. While distance and monophyly-based methods commonly use COI as the ideal gene for barcoding, the character-based approach can perform well for species identification using relatively conserved gene markers (e.g., 16S rDNA in this study). Nevertheless, distance and monophyly-based methods, especially the monophyly-based method, can still be used to flag species

A decision support system for multi-target geosteering

Geosteering is a sequential decision process under uncertainty. The goal of geosteering is to maximize the expected value of the well, which should be defined by an objective value-function for each operation. In this paper we present a real-time decision support system (DSS) for geosteering that aims to approximate the uncertainty in the geological interpretation with an ensemble of geomodel realizations. As the drilling operation progresses, the ensemble Kalman filter is used to sequentially update the realizations using the measurements from real-time logging while drilling. At every decision point a discrete dynamic programming algorithm computes all potential well trajectories for the entire drilling operation and the corresponding value of the well for each realization. Then, the DSS considers all immediate alternatives (continue/steer/stop) and chooses the one that gives the best predicted value across the realizations. This approach works for a variety of objectives and constraints and suggests reproducible decisions under uncertainty. Moreover, it has real-time performance. The system is tested on synthetic cases in a layer-cake geological environment where the target layer should be selected dynamically based on the prior (pre-drill) model and the electromagnetic observations received while drilling. The numerical closed-loop simulation experiments demonstrate the ability of the DSS to perform successful geosteering and landing of a well for different geological configurations of drilling targets. Furthermore, the DSS allows to adjust and re-weight the objectives, making the DSS useful before fully-automated geosteering becomes reality.publishedVersio

Specific Alleles of Bitter Receptor Genes Influence Human Sensitivity to the Bitterness of Aloin and Saccharin

SummaryVariation in human taste is a well-known phenomenon [1]. However, little is known about the molecular basis for it. Bitter taste in humans is believed to be mediated by a family of 25 G protein-coupled receptors (hT2Rs, or TAS2Rs) [2–7]. Despite recent progress in the functional expression of hT2Rs in vitro, up until now, hT2R38, a receptor for phenylthiocarbamide (PTC), was the only gene directly linked to variations in human bitter taste [8]. Here we report that polymorphism in two hT2R genes results in different receptor activities and different taste sensitivities to three bitter molecules. The hT2R43 gene allele, which encodes a protein with tryptophan in position 35, makes people very sensitive to the bitterness of the natural plant compounds aloin and aristolochic acid. People who do not possess this allele do not taste these compounds at low concentrations. The same hT2R43 gene allele makes people more sensitive to the bitterness of an artificial sweetener, saccharin. In addition, a closely related gene's (hT2R44's) allele also makes people more sensitive to the bitterness of saccharin. We also demonstrated that some people do not possess certain hT2R genes, contributing to taste variation between individuals. Our findings thus reveal new examples of variations in human taste and provide a molecular basis for them