3,169 research outputs found
The resilience of interdependent transportation networks under targeted attack
Modern world builds on the resilience of interdependent infrastructures
characterized as complex networks. Recently, a framework for analysis of
interdependent networks has been developed to explain the mechanism of
resilience in interdependent networks. Here we extend this interdependent
network model by considering flows in the networks and study the system's
resilience under different attack strategies. In our model, nodes may fail due
to either overload or loss of interdependency. Under the interaction between
these two failure mechanisms, it is shown that interdependent scale-free
networks show extreme vulnerability. The resilience of interdependent SF
networks is found in our simulation much smaller than single SF network or
interdependent SF networks without flows.Comment: 5 pages, 4 figure
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Epigenetic Down-Regulation of Sirt 1 via DNA Methylation and Oxidative Stress Signaling Contributes to the Gestational Diabetes Mellitus-Induced Fetal Programming of Heart Ischemia-Sensitive Phenotype in Late Life.
Rationale: The incidence of gestational diabetes mellitus (GDM) is increasing worldwide. However, whether and how GDM exposure induces fetal programming of adult cardiac dysfunctional phenotype, especially the underlying epigenetic molecular mechanisms and theranostics remain unclear. To address this problem, we developed a late GDM rat model. Methods: Pregnant rats were made diabetic on day 12 of gestation by streptozotocin (STZ). Experiments were conducted in 6 weeks old offspring. Results: There were significant increases in ischemia-induced cardiac infarction and gender-dependent left ventricular (LV) dysfunction in male offspring in GDM group as compared to controls. Exposure to GDM enhanced ROS level and caused a global DNA methylation in offspring cardiomyocytes. GDM attenuated cardiac Sirt 1 protein and p-Akt/Akt levels, but enhanced autophagy-related proteins expression (Atg 5 and LC3 II/LC3 I) as compared to controls. Ex-vivo treatment of DNA methylation inhibitor, 5-Aza directly inhibited Dnmt3A and enhanced Sirt 1 protein expression in fetal hearts. Furthermore, treatment with antioxidant, N-acetyl-cysteine (NAC) in offspring reversed GDM-mediated DNA hypermethylation, Sirt1 repression and autophagy-related gene protein overexpression in the hearts, and rescued GDM-induced deterioration in heart ischemic injury and LV dysfunction. Conclusion: Our data indicated that exposure to GDM induced offspring cardiac oxidative stress and DNA hypermethylation, resulting in an epigenetic down-regulation of Sirt1 gene and aberrant development of heart ischemia-sensitive phenotype, which suggests that Sirt 1-mediated signaling is the potential therapeutic target for the heart ischemic disease in offspring
Fourth order transport model on Yin-Yang grid by multi-moment constrained finite volume scheme
AbstractA fourth order transport model is proposed for global computation with the application of multi-moment constrained finite volume (MCV) scheme and Yin-Yang overset grid. Using multi-moment concept, local degrees of freedom (DOFs) are point-wisely defined within each mesh element to build a cubic spatial reconstruction. The updating formulations for local DOFs are derived by adopting multi moments as constraint conditions, including volume-integrated average (VIA), point value (PV) and first order derivative value (DV). Using Yin-Yang grid eliminates the polar singularities and results in a quasi-uniform mesh over the whole globe. Each component of Yin-Yang grid is a part of the LAT-LON grid, an orthogonal structured grid, where the MCV formulations designed for Cartesian grid can be applied straightforwardly to develop the high order numerical schemes. Proposed MCV model is checked by widely used benchmark tests. The numerical results show that the present model has fourth order accuracy and is competitive to most existing ones
Regional Differential Information Entropy for Super-Resolution Image Quality Assessment
PSNR and SSIM are the most widely used metrics in super-resolution problems,
because they are easy to use and can evaluate the similarities between
generated images and reference images. However, single image super-resolution
is an ill-posed problem, there are multiple corresponding high-resolution
images for the same low-resolution image. The similarities can't totally
reflect the restoration effect. The perceptual quality of generated images is
also important, but PSNR and SSIM do not reflect perceptual quality well. To
solve the problem, we proposed a method called regional differential
information entropy to measure both of the similarities and perceptual quality.
To overcome the problem that traditional image information entropy can't
reflect the structure information, we proposed to measure every region's
information entropy with sliding window. Considering that the human visual
system is more sensitive to the brightness difference at low brightness, we
take quantization rather than linear quantization. To accelerate the
method, we reorganized the calculation procedure of information entropy with a
neural network. Through experiments on our IQA dataset and PIPAL, this paper
proves that RDIE can better quantify perceptual quality of images especially
GAN-based images.Comment: 8 pages, 9 figures, 4 table
Information Dissemination Model Based on User Attitude and Public Opinion Environment
Modeling the information dissemination process in social networks is a
challenging problem. Despite numerous attempts to address this issue, existing
studies often assume that user attitudes have only one opportunity to alter
during the information dissemination process. Additionally, these studies tend
to consider the transformation of user attitudes as solely influenced by a
single user, overlooking the dynamic and evolving nature of user attitudes and
the impact of the public opinion environment. In this paper, we propose a novel
model, UAPE, which considers the influence of the aforementioned factors on the
information dissemination process. Specifically, UAPE regards the user's
attitude towards the topic as dynamically changing, with the change jointly
affected by multiple users simultaneously. Furthermore, the joint influence of
multiple users can be considered as the impact of the public opinion
environment. Extensive experimental results demonstrate that the model achieves
an accuracy range of 91.62% to 94.01%, surpassing the performance of existing
research
Mesoscale regulation of droplet templates to tailor microparticle structures and functions
The hierarchical design of mesoscale structures in droplet templates determines the structure and functionality of the resultant microparticles. In this review, we summarize recent progress on the control of microfluidic emulsion templates for the synthesis of polymeric microparticles with desired functionality and internal structure. We introduce strategies for controlling the morphology and interfacial stability of emulsion templates. These strategies are based on manipulation of the mesoscale structure of amphiphilic molecules and nanoparticles at emulsion-droplet interfaces. We also discuss strategies for controlling the mesoscale structure of microparticles, which involve manipulating the interfacial mass-transfer and chemical reactions during template synthesis. We provide insight on the use of these strategies for the rational design and fabrication of polymeric microparticles with predictable internal structures and functionality at the single-particle level
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Oxycodone vs. sufentanil combined with quadratus lumborum block vs. transverse abdominis plane block in laparoscopic major gastrointestinal surgery: A randomized factorial trial protocol
Background: Multimodal analgesia plays a key role in enhanced recovery after surgery. Herein, we describe a trial protocol investigating the effects of oxycodone-vs. sufentanil-based patient-controlled analgesia in combination with quadratus lumborum block (QLB) vs. transverse abdominis plane block (TAPB) on quality of recovery following major laparoscopic gastrointestinal surgery. Methods: and analysis: This is a prospective, randomized, controlled clinical trial with a 2 × 2 factorial design. A total of 120 adult patients undergoing laparoscopic major gastrointestinal surgery will be randomized, in a 1:1:1:1 ratio, to receive one of two patient-controlled analgesia regimens (based on oxycodone or sufentanil) and one of two regional blocks (QLB or TAPB). The primary outcome measure of this trial is the quality of recovery at 24 h after surgery, assessed using the 15-item quality of recovery (QoR-15) scale. The secondary outcomes include QoR-15 scores at 48 and 72 h after surgery; visceral and incisional pain at rest and while coughing at 1, 6, 24 and 48 h postoperatively; analgesic consumption within 0–24 h and 24–48 h postoperatively; need for rescue analgesia; postoperative flatus time; postoperative adverse events (sedation, nausea and vomiting, use of antiemetics, respiratory depression, and dizziness); and length of postoperative hospital stay. Discussion: The results of this trial will provide evidence for the optimal multimodal analgesic strategy to improve the quality of recovery for patients undergoing laparoscopic major gastrointestinal surgery. Trial registration: This trial was registered at the Chinese Clinical Trial Registry (www.chictr.org.cn, identifier: ChiCTR2400080766)
Danshensu for Myocardial Ischemic Injury: Preclinical Evidence and Novel Methodology of Quality Assessment Tool
Background: Danshensu (DSS) possesses unique bioactivity on the cardiovascular system. However, there is a lack of systematical summary of DSS for acute myocardial ischemia injury and no quality assessment tool for the systematical review of cell experiments. Here, we aimed to assess the preclinical evidences and possible mechanisms of DSS for myocardial ischemia injury, and to develop a quality assessment tool for the systematical review of cell experiments.Methods: Thirty-two studies with 473 animals and 134 cells were identified by searching seven databases. All data analysis was performed using RevMan 5.3. CAMARADES 10-item checklist was used to assess the methodological quality of animal experiments. A new 10-item checklist was first developed to assess the methodological quality of cell studies.Results: The score of study quality ranged from 3 to 7 points in animal studies, while the cell studies scored 3–6 points. Meta-analysis showed that DSS had significant effects on reducing myocardial infarct (MI) size in vivo, and increasing cell viability and reducing apoptosis rate in vitro compared with controls (P < 0.01). The possible mechanisms of DSS for MI are improving circulation, antioxidant, anti-apoptosis, anti-inflammatory, promoting angiogenesis, anti-excessive autophagy, anti-calcium overload, and improving energy metabolism.Conclusions: DSS could exert cardioprotective effect on myocardial ischemia injury, and thus is a probable candidate for further clinical trials andtreatment of AMI. In addition, the newly devloped 10-item checklist for assessing methodological quality of cell study that recommened to use the sysmatic review of cell studies
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