The universal "heartbeat" oscillations in black hole systems accross the mass-scale

The hyperluminous X-ray source (HLX-1, the peak X-ray luminosity $\sim 10^{42}\rm erg\ s^{-1}$) near the spiral galaxy ESO 243-49 is possibly the best candidate for intermediate mass black hole (IMBH), which underwent recurrent outbursts with a period of $\sim 400$ days. The physical reason for this quasi-periodic variability is still unclear. We explore the possibility of radiation-pressure instability in accretion disk by modeling the light curve of HLX-1, and find that it can roughly reproduce the duration, period and amplitude of the recurrent outbursts HLX-1 with an IMBH of ~10^5Msun. Our result provides a possible mechanism to explain the recurrent outbursts in HLX-1. We further find a universal correlation between the outburst duration and the bolometric luminosity for the BH sources with a very broad mass range (e.g., X-ray binaries, XRBs, HLX-1 and active galactic nuclei, AGNs), which is roughly consistent with the prediction of radiation-pressure instability of the accretion disk. These results imply that "heartbeat" oscillations triggered by radiation-pressure instability may appears in different-scale BH systems.Comment: ApJ in press; 15 pages, 5 Figure

A STUDY ON THE INHIBITORY EFFECT OF SOLANUM LYRATUM THUNB EXTRACT ON LEWIS LUNG CARCINOMA LINES

The objective of this paper was to observe the effects of Solanum lyratum Thunb extract on tumour inhibition, immune function and survival time of tumour-bearing mice. Lung carcinoma-bearing mouse model was established, the tumour-bearing mice were divided into model group, CTX group, Solanum lyratum Thunb extract high-dose group and low-dose group. By the examination of tumour inhibition rate of Solanum lyratum Thunb extract in Lewis lung carcinoma-bearing mice and determination of the number of NK cells and T cell subsets, the survival rate of tumour-bearing mice was observed. Solanum lyratum Thunb extract had some anti-tumour effect in Lewis tumour-bearing mice. The tumour inhibition rate of high-dose group reached 46.28%, and the tumour inhibition rate of low-dose group was 31.42%. Solanum lyratum Thunb extract can improve the NK cell activity of Lewis tumour-bearing mice, increase the number of CD4 cells in the tumour-bearing mice, and significantly increase the survival rate of tumour-bearing mice. The study concluded that Solanum lyratum Thunb extract has some anti-tumour effect and can improve immune function and survival rate of tumour-bearing mice

EFFECTS OF ETHANOL EXTRACT OF RADIX SOPHORAE FLAVESCENTIS ON ACTIVITY OF COLON CANCER HT29 CELLS

This paper mainly studied the inhibitory effect of total ethanol extract of Radix Sophorae Flavescentis on proliferation of colon cancer HT29 cells. By reflux extraction method and with ethanol as extraction solvent, different extracts were obtained at different ethanol concentrations, different solid-liquid ratios, and at different times. And their inhibitory activities against HT29 cells were compared using MTT assay. The experimental results showed that the extraction processes under three conditions can all draw relatively high inhibition rates. The optimum ethanol extraction process conditions were as follows: a solid-liquid ratio of 1:9, 80 min of heat reflux extraction with 95% ethanol

Debiasing Recommendation with Personal Popularity

Global popularity (GP) bias is the phenomenon that popular items are recommended much more frequently than they should be, which goes against the goal of providing personalized recommendations and harms user experience and recommendation accuracy. Many methods have been proposed to reduce GP bias but they fail to notice the fundamental problem of GP, i.e., it considers popularity from a \textit{global} perspective of \textit{all users} and uses a single set of popular items, and thus cannot capture the interests of individual users. As such, we propose a user-aware version of item popularity named \textit{personal popularity} (PP), which identifies different popular items for each user by considering the users that share similar interests. As PP models the preferences of individual users, it naturally helps to produce personalized recommendations and mitigate GP bias. To integrate PP into recommendation, we design a general \textit{personal popularity aware counterfactual} (PPAC) framework, which adapts easily to existing recommendation models. In particular, PPAC recognizes that PP and GP have both direct and indirect effects on recommendations and controls direct effects with counterfactual inference techniques for unbiased recommendations. All codes and datasets are available at \url{https://github.com/Stevenn9981/PPAC}.Comment: Accepted by WWW'24 as a research full pape

Atrial fibrillation and electrophysiology in transgenic mice with cardiac-restricted overexpression of FKBP12

Cardiomyocyte-restricted overexpression of FK506-binding protein 12 transgenic (αMyHC-FKBP12) mice develop spontaneous atrial fibrillation (AF). The aim of the present study is to explore the mechanisms underlying the occurrence of AF in αMyHC-FKBP12 mice. Spontaneous AF was documented by telemetry in vivo and Langendorff-perfused hearts of αMyHC-FKBP12 and littermate control mice in vitro. Atrial conduction velocity was evaluated by optical mapping. The patch-clamp technique was applied to determine the potentially altered electrophysiology in atrial myocytes. Channel protein expression levels were evaluated by Western blot analyses. Spontaneous AF was recorded in four of seven αMyHC-FKBP12 mice but in none of eight nontransgenic (NTG) controls. Atrial conduction velocity was significantly reduced in αMyHC-FKBP12 hearts compared with NTG hearts. Interestingly, the mean action potential duration at 50% but not 90% was significantly prolonged in αMyHC-FKBP12 atrial myocytes compared with their NTG counterparts. Consistent with decreased conduction velocity, average peak Na+ current ( INa) density was dramatically reduced and the INa inactivation curve was shifted by approximately +7 mV in αMyHC-FKBP12 atrial myocytes, whereas the activation and recovery curves were unaltered. The Nav1.5 expression level was significantly reduced in αMyHC-FKBP12 atria. Furthermore, we found increases in atrial Cav1.2 protein levels and peak L-type Ca2+ current density and increased levels of fibrosis in αMyHC-FKBP12 atria. In summary, cardiomyocyte-restricted overexpression of FKBP12 reduces the atrial Nav1.5 expression level and mean peak INa, which is associated with increased peak L-type Ca2+ current and interstitial fibrosis in atria. The combined electrophysiological and structural changes facilitated the development of local conduction block and altered action potential duration and spontaneous AF. NEW & NOTEWORTHY This study addresses a long-standing riddle regarding the role of FK506-binding protein 12 in cardiac physiology. The work provides further evidence that FK506-binding protein 12 is a critical component for regulating voltage-gated sodium current and in so doing has an important role in arrhythmogenic physiology, such as atrial fibrillation

Istodobni dokaz i razlikovanje svinjskog cirkovirusa tip 2, virusa reprodukcijskog i respiratornog sindroma tip 2, parvovirusa i virusa bolesti Aujeszkoga višestrukom lančanom reakcijom polimerazom u odbijene prasadi sa sindromom kržljavosti.

A multiplex polymerase chain reaction (PCR) was designed for the simultaneous detection of four viruses involved in postweaning multisystemic wasting syndrome (PMWS) in pigs: porcine circovirus type 2 (PCV-2), type 2 porcine reproductive and respiratory syndrome virus (PRRSV), porcine parvovirus (PPV) and pseudorabies virus (PRV). Each of the four pairs of primers exclusively amplified the targeted fragment of the specific viruses. The sensitivity of the multiplex PCR, using purified plasmid constructs containing the specific viral target fragments, was 4.0×103, 4.5×103, 3.0×102 and 5.0×102 copies for PCV-2, type 2 PRRSV, PPV, PRV. Among 82 clinical samples, coinfection by PCV-2 and type 2 PRRSV was the most common. When compared with the virus isolation method commonly used to detect viruses, the multiplex PCR assay was found to be more sensitive and rapid and, as such, may prove to be a good alternative method for the detection of and differentiation in PMWS in pigs.Višestruka lančana reakcija polimerazom (PCR) razvijena je za istodobni dokaz četiriju virusa koji se nalaze kod sindroma kržljavosti odbijene prasadi: svinjskog cirkovirusa tip 2, virusa reprodukcijskog i respiratornog sindroma tip 2, parvovirusa i virusa bolesti Aujeszkoga. Svaki od četiri para početnica bio je specifičan isključivo za umnožavanje specifičnog fragmenta određenog virusa. Osjetljivost višestrukog PCR-a upotrebom pročišćenih konstrukata plazmida koji sadrže specifične virusne fragmente bila je na razini 4,0×103 kopija za svinjski cirkovirus tip 2, 4,5×103 kopija za virus reprodukcijskog i respiratornog sindroma, 3,0×102 za svinjski parvovirus i 5,0×102 kopija za virus bolesti Aujeszkoga. Među 82 klinička uzorka često je dokazana koinfekcija svinjskim cirkovirusom tip 2 i virusom respiratornog i reprodukcijskog sindroma. U usporedbi s izolacijom virusa, višestruka lančana reakcija polimerazom pokazala se osjetljivijom i bržom te se kao takva može rabiti kao alternativna metoda za dokaz i razlikovanje uzročnika sindroma kržljavosti prasadi