846 research outputs found
Bilateral congenital choanal atresia and osteoma of ethmoid sinus with supernumerary nostril: a case report and review of the literature
<p>Abstract</p> <p>Introduction</p> <p>Congenital choanal atresia is a relatively rare deformity, especially bilateral congenital choanal atresia. We report a case of bilateral congenital choanal atresia in a 22-year-old Chinese man, who was also diagnosed with congenital right accessory nasal deformity, osteoma of his left ethmoid sinus and congenital keratoleukoma of his right eye.</p> <p>Case presentation</p> <p>A 22-year-old Chinese man presented with mouth breathing, sleep snoring and difficult feeding after birth, with no olfactory sensation. Three-dimensional computed tomography revealed bilateral choanal atresia and a high density bony shadow in his left ethmoid sinus that extended to his left frontal sinus.</p> <p>Conclusions</p> <p>Choanal atresia is often accompanied by other congenital abnormalities. To the best of our knowledge, this is the first report of choanal atresia accompanied by congenital accessory nasal deformity and congenital keratoleukoma.</p
SLC29A1 single nucleotide polymorphisms as independent prognostic predictors for survival of patients with acute myeloid leukemia: an in vitro study
Prenatal and Early Postnatal Exposure to Cigarette Smoke Decreases BDNF/TrkB Signaling and Increases Abnormal Behaviors Later in Life
Background: Cigarette smoke exposure during prenatal and early postnatal periods increases the incidence of a variety of abnormal behaviors later in life. The purpose of this study was to identify the possible critical period of susceptibility to cigarette smoke exposure and evaluate the possibe effects of cigarette smoke during early life on brain-derived neurotrophic factor/neurotrophic tyrosine kinase receptor B signaling in the brain.
Methods: Three different age of imprinting control region mice were exposed to cigarette smoke or filtered air for 10 consecutive days beginning on either gestational day 7 by maternal exposure, or postnatal days 2 or 21 by direct inhalation. A series of behavioral profiles and neurotrophins in brain were measured 24 hours after mice received acute restraint stress for 1 hour on postnatal day 59.
Results: Cigarette smoke exposure in gestational day 7 and postnatal day 2 produced depression-like behaviors as evidenced by significantly increased immobility in both tail suspension and forced-swim test. Increased entry latencies, but not ambulation in the open field test, were also observed in the gestational day 7 and postnatal day 2 cigarette smoke exposure groups. Genetic analysis showed that gestational day 7 cigarette smoke exposure significantly altered mRNA level of brain derived neurotrophic factor/tyrosine kinase receptor B in the hippocampus. However, behavioral profiles and brain-derived neurotrophic factor/tyrosine kinase receptor B signaling were not significantly changed in PND21 cigarette smoke exposure group compared with FA group.
Conclusions: These results suggest that a critical period of susceptibility to cigarette smoke exposure exists in the prenatal and early postnatal period, which results a downregulation in brain-derived neurotrophic factor/tyrosine kinase receptor B signaling in the hippocampus and enhances depression-like behaviors later in life
Semantic-Aware Frame-Event Fusion based Pattern Recognition via Large Vision-Language Models
Pattern recognition through the fusion of RGB frames and Event streams has
emerged as a novel research area in recent years. Current methods typically
employ backbone networks to individually extract the features of RGB frames and
event streams, and subsequently fuse these features for pattern recognition.
However, we posit that these methods may suffer from key issues like sematic
gaps and small-scale backbone networks. In this study, we introduce a novel
pattern recognition framework that consolidates the semantic labels, RGB
frames, and event streams, leveraging pre-trained large-scale vision-language
models. Specifically, given the input RGB frames, event streams, and all the
predefined semantic labels, we employ a pre-trained large-scale vision model
(CLIP vision encoder) to extract the RGB and event features. To handle the
semantic labels, we initially convert them into language descriptions through
prompt engineering, and then obtain the semantic features using the pre-trained
large-scale language model (CLIP text encoder). Subsequently, we integrate the
RGB/Event features and semantic features using multimodal Transformer networks.
The resulting frame and event tokens are further amplified using self-attention
layers. Concurrently, we propose to enhance the interactions between text
tokens and RGB/Event tokens via cross-attention. Finally, we consolidate all
three modalities using self-attention and feed-forward layers for recognition.
Comprehensive experiments on the HARDVS and PokerEvent datasets fully
substantiate the efficacy of our proposed SAFE model. The source code will be
made available at https://github.com/Event-AHU/SAFE_LargeVLM.Comment: In Peer Revie
Physical protection by soil aggregates stabilizes soil organic carbon under simulated N deposition in a subtropical forest of China
This work was financially supported by the National Natural Science Foundation of China (Project No. 41101278, 41101302, 41541012), the State Scholarship Fund from China Scholarship Council (201408440300 and 201308440342), the Guangzhou High School's Science Research Program (10A033), Dongguan International Science and Technology Cooperation project (including Hong Kong, Macao and Taiwan) (2013508101020) and NERC UK project NE/N007611/1.Peer reviewedPostprin
Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population
Physical properties and chemical composition of the cores in the California molecular cloud
We aim to reveal the physical properties and chemical composition of the
cores in the California molecular cloud (CMC), so as to better understand the
initial conditions of star formation. We made a high-resolution column density
map (18.2") with Herschel data, and extracted a complete sample of the cores in
the CMC with the \textsl{fellwalker} algorithm. We performed new
single-pointing observations of molecular lines near 90 GHz with the IRAM 30m
telescope along the main filament of the CMC. In addition, we also performed a
numerical modeling of chemical evolution for the cores under the physical
conditions. We extracted 300 cores, of which 33 are protostellar and 267 are
starless cores. About 51\% (137 of 267) of the starless cores are prestellar
cores. Three cores have the potential to evolve into high-mass stars. The
prestellar core mass function (CMF) can be well fit by a log-normal form. The
high-mass end of the prestellar CMF shows a power-law form with an index
that is shallower than that of the Galactic field stellar
mass function. Combining the mass transformation efficiency ()
from the prestellar core to the star of and the core formation
efficiency (CFE) of 5.5\%, we suggest an overall star formation efficiency of
about 1\% in the CMC. In the single-pointing observations with the IRAM 30m
telescope, we find that 6 cores show blue-skewed profile, while 4 cores show
red-skewed profile. []/[HNC] and []/ in protostellar cores are higher than those in prestellar cores;
this can be used as chemical clocks. The best-fit chemical age of the cores
with line observations is ~years.Comment: Accepted by Astronomy & Astrophysics (A&A
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