Characterizing Ordered Semigroups by Means of Intuitionistic Fuzzy Bi-ideals

In this paper, we endow set S with the structure of an ordered semigroup and define “intuitionistic fuzzy” analogous for several notions that have been proved to be useful in the theory of ordered semigroups and give some equivalent conditions of these definitions. Then we characterize the completely regular and the strongly regular ordered semigroups by means of intuitionistic fuzzy bi-ideals.Peer Reviewe

An extensive analysis of the presence of altmetric data for Web of Science publications across subject fields and research topics

Sufficient data presence is one of the key preconditions for applying metrics in practice. Based on both Altmetric.com data and Mendeley data collected up to 2019, this paper presents a state-of-the-art analysis of the presence of 12 kinds of altmetric events for nearly 12.3 million Web of Science publications published between 2012 and 2018. Results show that even though an upward trend of data presence can be observed over time, except for Mendeley readers and Twitter mentions, the overall presence of most altmetric data is still low. The majority of altmetric events go to publications in the fields of Biomedical and Health Sciences, Social Sciences and Humanities, and Life and Earth Sciences. As to research topics, the level of attention received by research topics varies across altmetric data, and specific altmetric data show different preferences for research topics, on the basis of which a framework for identifying hot research topics is proposed and applied to detect research topics with higher levels of attention garnered on certain altmetric data source. Twitter mentions and policy document citations were selected as two examples to identify hot research topics of interest of Twitter users and policy-makers, respectively, shedding light on the potential of altmetric data in monitoring research trends of specific social attention

Second-Line Combination Chemotherapy with Docetaxel and Nedaplatin for Cisplatin-Pretreated Refractory Metastatic/Recurrent Esophageal Squamous Cell Carcinoma

Background:There is an urgent need for an effective second-line chemotherapy regimen after failure of the standard cisplatin and 5-fluorouracil therapy.Patients and Methods:This study investigated the efficacy and toxicity of the combination of docetaxel (30 mg/m2) during a 1-hour infusion, followed by nedaplatin (50 mg/m2) during a 2-hour infusion (both drugs were administered on day 1 as an outpatient regimen and repeated every 2 weeks) as second-line chemotherapy for patients with cisplatin-pretreated refractory metastatic/recurrent esophageal squamous cell carcinoma after surgery.Results:Forty-six of the 48 patients (95.8%) were assessable for response. Partial response was confirmed in 13 of 48 cases yielding a response rate of 27.1% (95% confidence interval [CI], 14.5–39.7%). The median overall time to progression and overall survival was 3.1 months (95% CI, 2.3–3.9 months) and 5.9 months (95% CI, 3.9–7.8 months), respectively. The estimate of overall survival at 12 months was 16.7% (95% CI, 6.1–27.2%). Grade 3 anemia leucopenia, grade 4 anemia leucopenia and neutropenia were detected in only 4 (8.7%), 8 (17.4%), and 9 patients (19.6%), respectively.Conclusions:The combination chemotherapy of docetaxel and nedaplatin in the outpatient setting is well tolerated and useful as second-line chemotherapy for cisplatin-pretreated refractory metastatic/recurrent esophageal squamous cell carcinoma

4-Methyl-2,7-dioxo-3,6-dioxa-1(1,1′)-ferrocenacyclo­hepta­phane

In the title compound, [Fe(C15H14O4)], the two cyclo­penta­dienyl (Cp) rings are nearly parallel, making a dihedral angle of 2.6 (1)°. The distance between the centroids of the Cp rings is 3.309 (8) Å. The relative orientation of the two Cp rings is characterized by a torsion angle of −43.99 (6)° defined by the two centroids and the two substituted C atoms

The nutrition-based comprehensive intervention study on childhood obesity in China (NISCOC): a randomised cluster controlled trial

<p>Abstract</p> <p>Background</p> <p>Childhood obesity and its related metabolic and psychological abnormalities are becoming serious health problems in China. Effective, feasible and practical interventions should be developed in order to prevent the childhood obesity and its related early onset of clinical cardiovascular diseases. The objective of this paper is to describe the design of a multi-centred random controlled school-based clinical intervention for childhood obesity in China. The secondary objective is to compare the cost-effectiveness of the comprehensive intervention strategy with two other interventions, one only focuses on nutrition education, the other only focuses on physical activity.</p> <p>Methods/Design</p> <p>The study is designed as a multi-centred randomised controlled trial, which included 6 centres located in Beijing, Shanghai, Chongqing, Shandong province, Heilongjiang province and Guangdong province. Both nutrition education (special developed carton style nutrition education handbook) and physical activity intervention (Happy 10 program) will be applied in all intervention schools of 5 cities except Beijing. In Beijing, nutrition education intervention will be applied in 3 schools and physical activity intervention among another 3 schools. A total of 9750 primary students (grade 1 to grade 5, aged 7-13 years) will participate in baseline and intervention measurements, including weight, height, waist circumference, body composition (bioelectrical impendence device), physical fitness, 3 days dietary record, physical activity questionnaire, blood pressure, plasma glucose and plasma lipid profiles. Data concerning investments will be collected in our study, including costs in staff training, intervention materials, teachers and school input and supervising related expenditure.</p> <p>Discussion</p> <p>Present study is the first and biggest multi-center comprehensive childhood obesity intervention study in China. Should the study produce comprehensive results, the intervention strategies would justify a national school-based program to prevent childhood obesity in China.</p> <p>Trial Registration</p> <p>Chinese clinical trial registry (Primary registry in the WHO registry network) Identifier: ChiCTR-TRC-00000402</p