The largest virialized dark halo in the universe

Using semi-analytic approach, we present an estimate of the properties of the largest virialized dark halos in the present universe for three different scenarios of structure formation: SCDM, LCDM and OCDM models. The resulting virial mass and temperature increase from the lowest values of $1.6 \times 10^{15}h^{-1}M_{\odot}$ and 9.8 keV in OCDM, the mid-range values of $9.0 \times 10^{15}h^{-1}M_{\odot}$ and 31 keV in LCDM, to the highest values of $20.9 \times 10^{15}h^{-1}M_{\odot}$, 65 keV in SCDM. As compared with the largest virialized object seen in the universe, the richest clusters of galaxies, we can safely rule out the OCDM model. In addition, the SCDM model is very unlikely because of the unreasonably high virial mass and temperature. Our computation favors the prevailing LCDM model in which superclusters may be marginally regarded as dynamically-virialized systems.Comment: 5 pages, Accepted by Int. J. Mod. Phys.

The Navigation Engineering in Developed Hydropower Station

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchive

Mobile phone dependence, social support and impulsivity in Chinese university students

This study examined the frequency of mobile phone dependence in Chinese university students and explored its association with social support and impulsivity. Altogether, 909 university students were consecutively recruited from a large university in China. Mobile phone use, mobile phone dependence, impulsivity, and social support were measured with standardized instruments. The frequency of possible mobile phone use and mobile phone dependence was 78.3% and 7.4%, respectively. Multinomial logistic regression analyses revealed that compared with no mobile phone dependence, possible mobile phone dependence was significantly associated with being male (p = 0.04, OR = 0.7, 95% CI: 0.4–0.98), excessive mobile phone use (p \u3c 0.001, OR = 1.2, 95% CI: 1.09–1.2), and impulsivity (p \u3c 0.001, OR = 1.05, 95% CI: 1.03–1.06), while mobile phone dependence was associated with length of weekly phone use (p = 0.01, OR = 2.5, 95% CI: 1.2–5.0), excessive mobile phone use (p \u3c 0.001, OR = 1.3, 95% CI: 1.2–1.4), and impulsivity (p \u3c 0.001, OR = 1.08, 95% CI: 1.05–1.1). The frequency of possible mobile phone dependence and mobile phone dependence was high in this sample of Chinese university students. A significant positive association with impulsivity was found, but not with social support

4,6-Bis[5-methyl-3-(trifluoro­meth­yl)pyrazol-1-yl]pyrimidine

The complete mol­ecule of the the title compound, C14H10F6N6, is generated by crystallographic twofold symmetry, with two C atoms lying on the roatation axis. The dihedral angle between the central and peripheral rings is 25.97 (8)°

The psychometric properties of the quick inventory of depressive symptomatology-self-report (QIDS-SR) in patients with HBV-related liver disease

Background: Comorbid depression in Hepatitis B virus (HBV) is common. Developing accurate and time efficient tools to measure depressive symptoms in HBV is important for research and clinical practice in China. Aims: This study tested the psychometric properties of the Chinese version of the 16-item Quick Inventory of Depressive Symptomatology (QIDS-SR) in HBV patients. Methods: The study recruited 245 depressed patients with HBV and related liver disease. The severity of depressive symptoms was assessed with the Montgomery-Asberg Depression Rating Scale (MADRS) and the QIDS-SR. Results: Internal consistency (Cronbach’s alpha) was 0.796 for QIDS-SR. The QIDS-SR total score was significantly correlated with the MADRS total score (r=0.698, p. Conclusions: The QIDS-SR (Chinese version) has good psychometric properties in HBV patients and appears to be useful in assessing depression in clinical settings

Look, Read and Feel: Benchmarking Ads Understanding with Multimodal Multitask Learning

Given the massive market of advertising and the sharply increasing online multimedia content (such as videos), it is now fashionable to promote advertisements (ads) together with the multimedia content. It is exhausted to find relevant ads to match the provided content manually, and hence, some automatic advertising techniques are developed. Since ads are usually hard to understand only according to its visual appearance due to the contained visual metaphor, some other modalities, such as the contained texts, should be exploited for understanding. To further improve user experience, it is necessary to understand both the topic and sentiment of the ads. This motivates us to develop a novel deep multimodal multitask framework to integrate multiple modalities to achieve effective topic and sentiment prediction simultaneously for ads understanding. In particular, our model first extracts multimodal information from ads and learn high-level and comparable representations. The visual metaphor of the ad is decoded in an unsupervised manner. The obtained representations are then fed into the proposed hierarchical multimodal attention modules to learn task-specific representations for final prediction. A multitask loss function is also designed to train both the topic and sentiment prediction models jointly in an end-to-end manner. We conduct extensive experiments on the latest and large advertisement dataset and achieve state-of-the-art performance for both prediction tasks. The obtained results could be utilized as a benchmark for ads understanding.Comment: 8 pages, 5 figure

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter.

The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by effective anti-retroviral therapy. Although a number of LRAs have been found to reactivate latent HIV, they have not been used clinically due to high toxicity and poor efficacy. In this study, we report the identification of a chalcone analogue called Amt-87 that can significantly reactivate the transcription of latent HIV provirses and act synergistically with known LRAs such as prostratin and JQ1 to reverse latency. Amt-87 works by activating the human transcriptional elongation factor P-TEFb, a CDK9-cyclin T1 heterodimer that is part of the super elongation complex (SEC) used by the viral encoded Tat protein to activate HIV transcription. Amt-87 does so by promoting the phosphorylation of CDK9 at the T-loop, liberating P-TEFb from the inactive 7SK snRNP, and inducing the formation of the Tat-SEC complex at the viral promoter. Together, our data reveal chalcones as a promising category of compounds that should be further explored to identify effective LRAs for targeted reversal of HIV latency

Prevalence of internet addiction disorder in Chinese university students: A comprehensive meta-analysis of observational studies

Background and aims: Internet addiction disorder (IAD) is common in university students. A number of studies have examined the prevalence of IAD in Chinese university students, but the results have been inconsistent. This is a meta-analysis of the prevalence of IAD and its associated factors in Chinese university students. Methods: Both English (PubMed, PsycINFO, and Embase) and Chinese (Wan Fang Database and Chinese National Knowledge Infrastructure) databases were systematically and independently searched from their inception until January 16, 2017. Results: Altogether 70 studies covering 122,454 university students were included in the meta-analysis. Using the random-effects model, the pooled overall prevalence of IAD was 11.3% (95% CI: 10.1%–12.5%). When using the 8-item Young Diagnostic Questionnaire, the 10-item modified Young Diagnostic Questionnaire, the 20-item Internet Addiction Test, and the 26-item Chen Internet Addiction Scale, the pooled prevalence of IAD was 8.4% (95% CI: 6.7%–10.4%), 9.3% (95% CI: 7.6%–11.4%), 11.2% (95% CI: 8.8%–14.3%), and 14.0% (95% CI: 10.6%–18.4%), respectively. Subgroup analyses revealed that the pooled prevalence of IAD was significantly associated with the measurement instrument (Q = 9.41, p = .024). Male gender, higher grade, and urban abode were also significantly associated with IAD. The prevalence of IAD was also higher in eastern and central of China than in its northern and western regions (10.7% vs. 8.1%, Q = 4.90, p = .027). Conclusions: IAD is common among Chinese university students. Appropriate strategies for the prevention and treatment of IAD in this population need greater attention

4-(4-Chloro-5-methyl-3-trifluoro­meth­yl-1H-pyrazol-1-yl)-6-(prop-2-ynyl­oxy)pyrimidine

The molecule of the title compound, C12H8ClF3N4O, is twisted as indicated by the C—O—C—C torsion angle of 76.9 (3)°. Moreover, the trifluoro­methyl group shows rotational disorder of the F atoms, with site-occupancy factors of 0.653 (6) and 0.347 (6). The dihedral angle between the rings is 1.88 (12) Å