2,899 research outputs found
Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer
Model Spider: Learning to Rank Pre-Trained Models Efficiently
Figuring out which Pre-Trained Model (PTM) from a model zoo fits the target
task is essential to take advantage of plentiful model resources. With the
availability of numerous heterogeneous PTMs from diverse fields, efficiently
selecting the most suitable PTM is challenging due to the time-consuming costs
of carrying out forward or backward passes over all PTMs. In this paper, we
propose Model Spider, which tokenizes both PTMs and tasks by summarizing their
characteristics into vectors to enable efficient PTM selection. By leveraging
the approximated performance of PTMs on a separate set of training tasks, Model
Spider learns to construct tokens and measure the fitness score between a
model-task pair via their tokens. The ability to rank relevant PTMs higher than
others generalizes to new tasks. With the top-ranked PTM candidates, we further
learn to enrich task tokens with their PTM-specific semantics to re-rank the
PTMs for better selection. Model Spider balances efficiency and selection
ability, making PTM selection like a spider preying on a web. Model Spider
demonstrates promising performance in various configurations of model zoos
microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma.
Glycolysis was reported to have a positive correlation with radioresistance. Our previous study found that the miR-33a functioned as a tumor suppressor in malignant melanoma by targeting hypoxia-inducible factor1-alpha (HIF-1α), a gene known to promote glycolysis. However, the role of miR-33a-5p in radiosensitivity remains to be elucidated. We found that miR-33a-5p was downregulated in melanoma tissues and cells. Cell proliferation was downregulated after overexpression of miR-33a-5p in WM451 cells, accompanied by a decreased level of glycolysis. In contrast, cell proliferation was upregulated after inhibition of miR-33a-5p in WM35 cells, accompanied by increased glycolysis. Overexpression of miR-33a-5p enhanced the sensitivity of melanoma cells to X-radiation by MTT assay, while downregulation of miR-33a-5p had the opposite effects. Finally, in vivo experiments with xenografts in nude mice confirmed that high expression of miR-33a-5p in tumor cells increased radiosensitivity via inhibiting glycolysis. In conclusions, miR-33a-5p promotes radiosensitivity by negatively regulating glycolysis in melanoma
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A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs.
mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown whether RNAs play any role in this process. Unexpectedly, we found that a subset of small nucleolar RNAs (snoRNAs) are associated with the mammalian mRNA 3' processing complex. These snoRNAs primarily interact with Fip1, a component of cleavage and polyadenylation specificity factor (CPSF). We have functionally characterized one of these snoRNAs and our results demonstrated that the U/A-rich SNORD50A inhibits mRNA 3' processing by blocking the Fip1-poly(A) site (PAS) interaction. Consistently, SNORD50A depletion altered the Fip1-RNA interaction landscape and changed the alternative polyadenylation (APA) profiles and/or transcript levels of a subset of genes. Taken together, our data revealed a novel function for snoRNAs and provided the first evidence that non-coding RNAs may play an important role in regulating mRNA 3' processing
Effects of Sangu Decoction on Osteoclast Activity in a Rat Model of Breast Cancer Bone Metastasis
Bone metastasis (BM) is a major clinical problem for which current treatments lack full efficacy. The Traditional Chinese Medicine (TCM) Sangu Decoction (SGD) has been widely used to treat BM in China. However, no in vivo experiments to date have investigated the effects of TCM on osteoclast activity in BM. In this study, the protective effect and probable mechanism of SGD were evaluated. The model was established using the breast cancer MRMT-1 cells injected into the tibia of rat. SGD was administrated, compared with Zoledronic acid as a positive control. The development of the bone tumor and osteoclast activity was monitored by radiological analysis. TRAP stain was used to identify osteoclasts quantity and activity. TRAP-5b in serum or bone tumor and TRAP mRNA were also quantified. Radiological examination showed that SGD inhibited tumor proliferation and preserved the cortical and trabecular bone structure. In addition, a dramatic reduction of TRAP positive osteoclasts was observed and TRAP-5b levels in serum and bone tumor decreased significantly. It also reduced the mRNA expression of TRAP. The results indicated that SGD exerted potent antiosteoclast property that could be directly related to its TRAP inhibited activity. In addition it prevented bone tumor proliferation in BM model
Visualizing the elongated vortices in -Ga nanostrips
We study the magnetic response of superconducting -Ga via low
temperature scanning tunneling microscopy and spectroscopy. The magnetic vortex
cores rely substantially on the Ga geometry, and exhibit an unexpectedly-large
axial elongation with aspect ratio up to 40 in rectangular Ga nano-strips
(width 100 nm). This is in stark contrast with the isotropic circular
vortex core in a larger round-shaped Ga island. We suggest that the unusual
elongated vortices in Ga nanostrips originate from geometric confinement effect
probably via the strong repulsive interaction between the vortices and Meissner
screening currents at the sample edge. Our finding provides novel conceptual
insights into the geometrical confinement effect on magnetic vortices and forms
the basis for the technological applications of superconductors.Comment: published in Phys. Rev. B as a Rapid Communicatio
Testing and Data Reduction of the Chinese Small Telescope Array (CSTAR) for Dome A, Antarctica
The Chinese Small Telescope ARray (hereinafter CSTAR) is the first Chinese
astronomical instrument on the Antarctic ice cap. The low temperature and low
pressure testing of the data acquisition system was carried out in a laboratory
refrigerator and on the 4500m Pamirs high plateau, respectively. The results
from the final four nights of test observations demonstrated that CSTAR was
ready for operation at Dome A, Antarctica. In this paper we present a
description of CSTAR and the performance derived from the test observations.Comment: Accepted Research in Astronomy and Astrophysics (RAA) 1 Latex file
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Geometry and optics calibration of WFCTA prototype telescopes using star light
The Large High Altitude Air Shower Observatory project is proposed to study
high energy gamma ray astronomy ( 40 GeV-1 PeV ) and cosmic ray physics ( 20
TeV-1 EeV ). The wide field of view Cherenkov telescope array, as a component
of the LHAASO project, will be used to study energy spectrum and compositions
of cosmic ray by measuring the total Cherenkov light generated by air showers
and shower maximum depth. Two prototype telescopes have been in operation since
2008. The pointing accuracy of each telescope is crucial to the direction
reconstruction of the primary particles. On the other hand the primary energy
reconstruction relies on the shape of the Cherenkov image on the camera and the
unrecorded photons due to the imperfect connections between photomultiplier
tubes. UV bright stars are used as point-like objects to calibrate the pointing
and to study the optical properties of the camera, the spot size and the
fractions of unrecorded photons in the insensitive areas of the camera.Comment: 5 pages, 6 figures, submitted to Chinese Physics
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