Tentative evidence of spatially extended GeV emission from SS433/W50

We analyze 10 years of Fermi-LAT data towards the SS433/W50 region. With the latest source catalog and diffuse background models, the gamma-ray excess from SS433/W50 is detected with a significance of 6{\sigma} in the photon energy range of 500 MeV - 10 GeV. Our analysis indicates that an extended flat disk morphology is preferred over a point-source description, suggesting that the GeV emission region is much larger than that of the TeV emission detected by HAWC. The size of the GeV emission is instead consistent with the extent of the radio nebula W50, a supernova remnant being distorted by the jets, so we suggest that the GeV emission may originate from this supernova remnant. The spectral result of the GeV emission is also consistent with an supernova remnant origin. We also derive the GeV flux upper limits on the TeV emission region, which put moderate constrains on the leptonic models to explain the multiwavelength data.Comment: 7 pages, 4 figures, accepted for publication in A&

Detection of gamma-ray emission from the Coma cluster with Fermi Large Area Telescope and tentative evidence for an extended spatial structure

Many galaxy clusters have giant halos of non-thermal radio emission, indicating the presence of relativistic electrons in the clusters. Relativistic protons may also be accelerated by merger and/or accretion shocks in galaxy clusters. These cosmic-ray (CR) electrons and/or protons are expected to produce gamma-rays through inverse-Compton scatterings or inelastic $pp$ collisions respectively. Despite of intense efforts in searching for high-energy gamma-ray emission from galaxy clusters, conclusive evidence is still missing so far. Here we report the discovery of $\ge 200$ MeV gamma-ray emission from the Coma cluster direction with an unbinned likelihood analysis of the 9 years of {\it Fermi}-LAT Pass 8 data. The gamma-ray emission shows a spatial morphology roughly coincident with the giant radio halo, with an apparent excess at the southwest of the cluster. Using the test statistic analysis, we further find tentative evidence that the gamma-ray emission at the Coma center is spatially extended. The extended component has an integral energy flux of $\sim 2\times 10^{-12}{\rm \ erg\ cm^{-2}\ s^{-1}}$ in the energy range of 0.2 - 300 GeV and the spectrum is soft with a photon index of $\simeq-2.7$. Interpreting the gamma-ray emission as arising from CR proton interaction, we find that the volume-averaged value of the CR to thermal pressure ratio in the Coma cluster is about $\sim 2\%$. Our results show that galaxy clusters are likely a new type of GeV gamma-ray sources, and they are probably also giant reservoirs of CR protons.Comment: 10 pages, 10 figures, Accepted by Physical Review D, more spatial models for the gamma-ray emission are used, systematic checks on the results are adde

Identification and Characterization of the PEBP Family Genes in Moso Bamboo (Phyllostachys heterocycla).

Moso bamboo is one of the economically most important plants in China. Moso bamboo is a monocarpic perennial that exhibits poor and slow germination. Thus, the flowering often causes destruction of moso bamboo forestry. However, how control of flowering and seed germination are regulated in moso bamboo is largely unclear. In this study, we identified 5 members (PhFT1-5) of the phosphatidyl ethanolamine-binding proteins (PEBP) family from moso bamboo genome that regulate flowering, flower architecture and germination, and characterized the function of these PEBP family genes further in Arabidopsis. Phylogenetic analysis revealed that 3 (PhFT1, PhFT2 and PhFT3), 1 (PhFT4) and 1 (PhFT5) members belong to the TFL1-like clade, FT-like clade, and MFT-like clade, respectively. These PEBP family genes possess all structure necessary for PEBP gene function. The ectopic overexpression of PhFT4 and PhFT5 promotes flowering time in Arabidopsis, and that of PhFT1, PhFT2 and PhFT3 suppresses it. In addition, the overexpression of PhFT5 promotes seed germination rate. Interestingly, the overexpression of PhFT1 suppressed seed germination rate in Arabidopsis. The expression of PhFT1 and PhFT5 is significantly higher in seed than in tissues including leaf and shoot apical meristem, implying their function in seed germination. Taken together, our results suggested that the PEBP family genes play important roles as regulators of flowering and seed germination in moso bamboo and thereby are necessary for the sustainability of moso bamboo forest

Liquid biopsy biomarkers to guide immunotherapy in breast cancer

Immune checkpoint inhibitors (ICIs) therapy has emerged as a promising treatment strategy for breast cancer (BC). However, current reliance on immunohistochemical (IHC) detection of PD-L1 expression alone has limited predictive capability, resulting in suboptimal efficacy of ICIs for some BC patients. Hence, developing novel predictive biomarkers is indispensable to enhance patient selection for immunotherapy. In this context, utilizing liquid biopsy (LB) can provide supplementary or alternative value to PD-L1 IHC testing for identifying patients most likely to benefit from immunotherapy and exhibit favorable responses. This review discusses the predictive and prognostic value of LB in breast cancer immunotherapy, as well as its limitations and future directions. We aim to promote the individualization and precision of immunotherapy in BC by elucidating the role of LB in clinical practice

Effect of matrix suction on the shear strength characteristics of reinforced granite residual soil

Introduction: The soil in geogrid-reinforced structures is typically unsaturated, with the shear strength provided by both the matrix suction and the reinforced body. Traditional structural designs for saturated soils only consider the shear strength provided by the reinforced body, neglecting the part provided by matrix suction. As a result, the design for reinforced structures is biased toward conservatism.Method: The study examined the matrix suction-provided shear strength in reinforced soils through strain-controlled triaxial and soil-water characteristic curve (SWCC) pressure plate instrumentation. The feasibility of the Schrefler and Khalili unsaturated soil shear strength formulas for predicting shear strength based on matrix suction forces was verified.Results: The study revealed that the cohesion of saturated reinforced soil exhibits a significant decrease in contrast with unsaturated reinforced soil, with matrix suction serving as a crucial consideration for reinforced structure design.Discussion: The experimental results confirm the suitability of applying the quasi-cohesion increment theory to reinforced clays. The Khalili formula can be utilized to predict the quasi cohesion of unsaturated reinforced soils with greater accuracy under diverse dry density conditions. The results obtained using post-shear moisture content were closer to the measured values than those using initial moisture content

Can social interaction-oriented content trigger viewers' purchasing and gift-giving behaviors? Evidence from live-streaming commerce

Purpose: This study investigates how social interaction-oriented content in broadcasters' live speech affects broadcast viewers' purchasing and gift-giving behaviors and how broadcaster popularity moderates social interaction-oriented content's effect on the two different behaviors in live-streaming commerce. Design/methodology/approach: A research model was proposed and empirically tested using a panel data set collected from 537 live streams via Douyin (the Chinese version of TikTok), one of the most popular live broadcast platforms in China. A fixed-effects negative binomial regression model was used to examine the proposed research model. Findings: This study's results show that social interaction-oriented content in broadcasters' live speech has an inverted U-shaped relationship with broadcast viewers' purchasing behavior and shares a positive linear relationship with viewers' gift-giving behavior. Furthermore, broadcaster popularity significantly moderates the effect of social interaction-oriented content on viewers' purchasing and gift-giving behaviors. Originality/value: This research enriches the literature on live-streaming commerce by investigating how social interaction-oriented content in broadcasters' live speech affects broadcast viewers' product-purchasing and gift-giving behaviors from the perspective of broadcast viewers' attention. Moreover, this study provides some practical guidelines for developing live speech content in the live-streaming commerce context.publishedVersionPeer reviewe