Electron Cooling Experiments in CSR

The six species heavy ion beam was accumulated with the help of electron cooling in the main ring of Cooler Storage Ring of Heavy Ion Research Facility in Lanzhou(HIRFL-CSR), the ion beam accumulation dependence on the parameters of cooler was investigated experimentally. The 400MeV/u 12C6+ and 200MeV/u 129Xe54+ was stored and cooled in the experimental ring CSRe, the cooling force was measured in different condition.Comment: 5 pages 11 figure

A mathematical and computational review of Hartree-Fock SCF methods in Quantum Chemistry

We present here a review of the fundamental topics of Hartree-Fock theory in Quantum Chemistry. From the molecular Hamiltonian, using and discussing the Born-Oppenheimer approximation, we arrive to the Hartree and Hartree-Fock equations for the electronic problem. Special emphasis is placed in the most relevant mathematical aspects of the theoretical derivation of the final equations, as well as in the results regarding the existence and uniqueness of their solutions. All Hartree-Fock versions with different spin restrictions are systematically extracted from the general case, thus providing a unifying framework. Then, the discretization of the one-electron orbitals space is reviewed and the Roothaan-Hall formalism introduced. This leads to a exposition of the basic underlying concepts related to the construction and selection of Gaussian basis sets, focusing in algorithmic efficiency issues. Finally, we close the review with a section in which the most relevant modern developments (specially those related to the design of linear-scaling methods) are commented and linked to the issues discussed. The whole work is intentionally introductory and rather self-contained, so that it may be useful for non experts that aim to use quantum chemical methods in interdisciplinary applications. Moreover, much material that is found scattered in the literature has been put together here to facilitate comprehension and to serve as a handy reference.Comment: 64 pages, 3 figures, tMPH2e.cls style file, doublesp, mathbbol and subeqn package

Transcriptome and Network Changes in Climbers at Extreme Altitudes

Extreme altitude can induce a range of cellular and systemic responses. Although it is known that hypoxia underlies the major changes and that the physiological responses include hemodynamic changes and erythropoiesis, the molecular mechanisms and signaling pathways mediating such changes are largely unknown. To obtain a more complete picture of the transcriptional regulatory landscape and networks involved in extreme altitude response, we followed four climbers on an expedition up Mount Xixiabangma (8,012 m), and collected blood samples at four stages during the climb for mRNA and miRNA expression assays. By analyzing dynamic changes of gene networks in response to extreme altitudes, we uncovered a highly modular network with 7 modules of various functions that changed in response to extreme altitudes. The erythrocyte differentiation module is the most prominently up-regulated, reflecting increased erythrocyte differentiation from hematopoietic stem cells, probably at the expense of differentiation into other cell lineages. These changes are accompanied by coordinated down-regulation of general translation. Network topology and flow analyses also uncovered regulators known to modulate hypoxia responses and erythrocyte development, as well as unknown regulators, such as the OCT4 gene, an important regulator in stem cells and assumed to only function in stem cells. We predicted computationally and validated experimentally that increased OCT4 expression at extreme altitude can directly elevate the expression of hemoglobin genes. Our approach established a new framework for analyzing the transcriptional regulatory network from a very limited number of samples

Recognition of machining features and feature topologies from NC programs

The machining feature is a high-level product geometric representation and macro description of the product geometry. It is vital to machining operation planning and integration of CAD and CAM systems. In the feature-based operation planning, given a feature, the operator needs its associated machining operation data. Since successful NC programs contain machining know-how of skilled workers associated with the machining features, this paper studies the recognition of machining features in milling from the NC programs through reverse engineering, for reuse of the know-how in operation planning. First, the concepts of the machining element, machining feature and feature topology are presented, and the classification and representation of the features are performed from the machining point of view. Then algorithms for recognizing the machining features and feature topologies by analyzing NC programs are developed based on progressive Z-maps. Finally, a prototype is developed to extract the machining features and their associated operation data, and the machining know-how database is generated accordingly. The recognition of a variety of machining features and topologies, as well as their associated machining operations, is demonstrated through an example part from NIST parts repository. By using the generated machining know-how database, the machining operation planning will be automated by its counterpart system - the machining operation planner

Extraction of milling know-how from NC programs through reverse engineering

To automate machining process planning, the acquisition and representation of machining knowledge or know-how in a reusable way is needed. The machining know-how is implied in NC programs made by experienced workers. In this paper, the methodology and system for extracting machining know-how in milling operations have been developed. With the system, machining features, operations and their associated cutting conditions (depth of cut, feed rate and spindle speed, etc.) and machining method can be extracted by analysing NC programs in conjunction with the tools used and workpiece blank model. The milling know-how is represented as a collection of these extracted data that can be used in future machining operations. To verify the system, actual NC programs for milling have been analysed and the milling know-how has been extracted successfully. © 2000 Taylor & Francis Group, LLC

Reverse engineering of machining operation planning

Computer-aided process planning (CAPP) is becoming increasingly crucial to today\u27s computer-integrated manufacturing (CIM) and rapid production. To automate the process planning, feature-based operation planning systems have been suggested and studied extensively. In such a system, given a machining feature, the operator requires practical machining operation data for the feature. In this research, a system of reverse engineering is proposed to extract machining features and their associated machining operation data. Furthermore, a machining know-how database containing the extracted data is created for future operation planning. Since successful NC programs contain the machining know-how of skilled workers, the system is aimed at extracting the machining know-how data from the NC programs through reverse engineering. The extraction of the machining features and feature topologies has been addressed previously. The present paper deals with the extraction of machining operation data, including operation sequence, cutting conditions, machining type and cutting mode. A prototype of the system is developed and a machining know-how database is generated. The extraction of machining features and their associated machining operations has been verified through a variety of NC programs