Janis-Newman-Winicour and Wyman solutions are the same

We show that the well-known most general static and spherically symmetric exact solution to the Einstein-massless scalar equations given by Wyman is the same as one found by Janis, Newman and Winicour several years ago. We obtain the energy associated with this spacetime and find that the total energy for the case of the purely scalar field is zero.Comment: 9 pages, LaTex, no figures, misprints corrected, to appear in Int. J. Mod. Phys.

Effects of jamming on non-equilibrium transport times in nano-channels

Many biological channels perform highly selective transport without direct input of metabolic energy and without transitions from a 'closed' to an 'open' state during transport. Mechanisms of selectivity of such channels serve as an inspiration for creation of artificial nano-molecular sorting devices and bio-sensors. To elucidate the transport mechanisms, it is important to understand the transport on the single molecule level in the experimentally relevant regime when multiple particles are crowded in the channel. In this paper we analyze the effects of inter-particle crowding on the non-equilibrium transport times through a finite-length channel by means of analytical theory and computer simulations

Efficacy of a self-help manual in increasing resilience in carers of adults with depression in Thailand

Caring for a person with a mental illness can have adverse effects on caregivers; however, little is known about how best to help such caregivers. The aim of the present study was to examine the efficacy of a cognitive behaviour therapy-guided self-help manual in increasing resilience in caregivers of individuals with depression, in comparison to caregivers who receive routine support only. A randomized, controlled trial was conducted, following CONSORT guidelines, with 54 caregivers allocated to parallel intervention (self-help manual) (n = 27) or control (standard support) (n = 27) groups. Resilience was assessed at baseline, post-test (week 8), and follow up (week 12). Intention-to-treat analyses were undertaken. Repeated-measures ANOVA indicated a significant difference in resilience scores between the three time points, showing a large effect. Pairwise comparisons between intervention and control groups indicated resilience to be significantly different between baseline and post-test, and between baseline and follow up, but not between post-test and follow up. Overall, the intervention group showed a slightly greater increase in resilience over time than the control group; however, the time–group interaction was not significant. Guided self-help is helpful in improving caregivers’ resilience and could be used as an adjunct to the limited support provided to carers by mental health nurses and other clinicians

Extreme objects with arbitrary large mass, or density, and arbitrary size

We consider a generalization of the interior Schwarzschild solution that we match to the exterior one to build global C^1 models that can have arbitrary large mass, or density, with arbitrary size. This is possible because of a new insight into the problem of localizing the center of symmetry of the models and the use of principal transformations to understand the structure of space.Comment: 20 pages, 6 figures. Fixed one reference. Added a new equatio

Open String Tachyon in Supergravity Solution

We study the tachyon condensation of the D-\bar{D}-brane system with a constant tachyon vev in the context of classical solutions of the Type II supergravity. We find that the general solution with the symmetry ISO(1,p)xSO(9-p) (the three-parameter solution) includes the extremal black p-brane solution as an appropriate limit of the solution with fixing one of the three parameters (c_1). Furthermore, we compare the long distance behavior of the solution with the massless modes of the closed strings from the boundary state of the D-\bar{D}-brane system with a constant tachyon vev. We find that we must fix c_1 to zero and the only two parameters are needed to express the tachyon condensation of the D\={D}-brane system. This means that the parameter $c_1$ does not correspond to the tachyon vev of the D\={D}-brane system.Comment: 20 pages, no figures, LaTeX2e, typos corrected, references added and more general result presente

All static spherically symmetric perfect fluid solutions of Einstein's Equations

An algorithm based on the choice of a single monotone function (subject to boundary conditions) is presented which generates all regular static spherically symmetric perfect fluid solutions of Einstein's equations. For physically relevant solutions the generating functions must be restricted by non-trivial integral-differential inequalities. Nonetheless, the algorithm is demonstrated here by the construction of an infinite number of previously unknown physically interesting exact solutions.Comment: Final form to appear in Phys Rev D. Includes a number of clarification

SLC19A1 transports immunoreactive cyclic dinucleotides.

The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway3. The binding of DNA to cGAS activates its enzymatic activity, leading to the synthesis of a second messenger, cyclic guanosine monophosphate-adenosine monophosphate (2'3'-cGAMP)4-7. This cyclic dinucleotide (CDN) activates STING8, which in turn activates the transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), promoting the transcription of genes encoding type I interferons and other cytokines and mediators that stimulate a broader immune response. Exogenous 2'3'-cGAMP produced by malignant cells9 and other CDNs, including those produced by bacteria10-12 and synthetic CDNs used in cancer immunotherapy13,14, must traverse the cell membrane to activate STING in target cells. How these charged CDNs pass through the lipid bilayer is unknown. Here we used a genome-wide CRISPR-interference screen to identify the reduced folate carrier SLC19A1, a folate-organic phosphate antiporter, as the major transporter of CDNs. Depleting SLC19A1 in human cells inhibits CDN uptake and functional responses, and overexpressing SLC19A1 increases both uptake and functional responses. In human cell lines and primary cells ex vivo, CDN uptake is inhibited by folates as well as two medications approved for treatment of inflammatory diseases, sulfasalazine and the antifolate methotrexate. The identification of SLC19A1 as the major transporter of CDNs into cells has implications for the immunotherapeutic treatment of cancer13, host responsiveness to CDN-producing pathogenic microorganisms11 and-potentially-for some inflammatory diseases

Isotropy, shear, symmetry and exact solutions for relativistic fluid spheres

The symmetry method is used to derive solutions of Einstein's equations for fluid spheres using an isotropic metric and a velocity four vector that is non-comoving. Initially the Lie, classical approach is used to review and provide a connecting framework for many comoving and so shear free solutions. This provides the basis for the derivation of the classical point symmetries for the more general and mathematicaly less tractable description of Einstein's equations in the non-comoving frame. Although the range of symmetries is restrictive, existing and new symmetry solutions with non-zero shear are derived. The range is then extended using the non-classical direct symmetry approach of Clarkson and Kruskal and so additional new solutions with non-zero shear are also presented. The kinematics and pressure, energy density, mass function of these solutions are determined.Comment: To appear in Classical and Quantum Gravit