Assessing the Feasibility of an Aerotropolis Around Cleveland Hopkins International Airport, Technical Report

This report provides an assessment of the feasibility of developing an aerotropolis around Cleveland Hopkins International Airport, Cleveland, Ohio. The report describes the methodology used to assess the feasibility, notes the needs and expectations of community stakeholders, profiles the challenges and successes of six emerging and potential U.S. aerotropolises, and discusses the operating experiences and challenges of 12 additional U.S. airports. Further, this report describes the demographic and economic aspects of the study cities, and discusses potential target industry opportunities. The findings suggest that it is feasible to develop CLE as an aerotropolis, and that CLE may not be suited for an aerotropolis as practiced at other domestic and international airports. Rather, the concept itself may be the platform for moving forward with a defined, staged strategy for development surrounding CLE and should be viewed as an opportunity to develop the concept to specifically fit the region and its economic circumstance

Assessing the Feasibility of an Aerotropolis Around Cleveland Hopkins International Airport, Technical Report

This report provides an assessment of the feasibility of developing an aerotropolis around Cleveland Hopkins International Airport, Cleveland, Ohio. The report describes the methodology used to assess the feasibility, notes the needs and expectations of community stakeholders, profiles the challenges and successes of six emerging and potential U.S. aerotropolises, and discusses the operating experiences and challenges of 12 additional U.S. airports. Further, this report describes the demographic and economic aspects of the study cities, and discusses potential target industry opportunities. The findings suggest that it is feasible to develop CLE as an aerotropolis, and that CLE may not be suited for an aerotropolis as practiced at other domestic and international airports. Rather, the concept itself may be the platform for moving forward with a defined, staged strategy for development surrounding CLE and should be viewed as an opportunity to develop the concept to specifically fit the region and its economic circumstance

Assessing the Feasibility of an Aerotropolis Around Cleveland Hopkins International Airport, Appendices

This is a companion report to the full technical report entitled, “Assessing the Feasibility of an Aerotropolis Around Cleveland Hopkins International Airport.” This report contains the supporting documents including interview scripts, focus group protocol, a reference list and glossary, cooperative economic development agreements, airport case studies, a map of physical property characteristics, and endnotes for the appendices

Jefferson Village Downtown District Plan

Jefferson Village is an incorporated municipality in Northeastern Ohio, with a population in 2000 of about 4000 residents. Originally founded in 1803 and incorporated in 1836, the Village has been the county seat for Ashtabula County since 1807. The Village is centrally located in Ashtabula County, 10 miles south of Lake Erie, and 10 miles west of the Pennsylvania border. Interstate highway 90 runs parallel to the lake shore, about 6 miles north of the village; and State Route 11 is a major north-south connector located about 2 miles east of the village. The primary employment locations in the Village are the downtown County administration and the independent professional offices that serve county-related needs, and a light industrial park to the southeast of downtown. The County fairground is also located within the village limits. While residential, commercial and retail growth have occurred over the years, the village still retains much of its original Western Reserve town character. Over 25% of the buildings in the downtown district have historic merit, and both Chestnut and Jefferson Streets are lined with older brick commercial buildings, as well as large, well-kept residences of Western Reserve, Georgian and Victorian architectural styles. Village administration is still based in the original Town Hall, and residents take much pride in the small town charm of the community. In 2006, new commercial development was proposed for Chestnut Street that would have required removal of a residence of historic character, replacing it with a new, generic commercial structure and a typical street-frontage parking lot. Residents were concerned, and public discourse in the local newspaper and at Town Hall led to withdrawal of the proposal. Village leadership felt that it was time to explore the historic character and economic future of the downtown district, and establish policy that could guide future decision making for the downtown

Jefferson Village Downtown District Plan

Jefferson Village is an incorporated municipality in Northeastern Ohio, with a population in 2000 of about 4000 residents. Originally founded in 1803 and incorporated in 1836, the Village has been the county seat for Ashtabula County since 1807. The Village is centrally located in Ashtabula County, 10 miles south of Lake Erie, and 10 miles west of the Pennsylvania border. Interstate highway 90 runs parallel to the lake shore, about 6 miles north of the village; and State Route 11 is a major north-south connector located about 2 miles east of the village. The primary employment locations in the Village are the downtown County administration and the independent professional offices that serve county-related needs, and a light industrial park to the southeast of downtown. The County fairground is also located within the village limits. While residential, commercial and retail growth have occurred over the years, the village still retains much of its original Western Reserve town character. Over 25% of the buildings in the downtown district have historic merit, and both Chestnut and Jefferson Streets are lined with older brick commercial buildings, as well as large, well-kept residences of Western Reserve, Georgian and Victorian architectural styles. Village administration is still based in the original Town Hall, and residents take much pride in the small town charm of the community. In 2006, new commercial development was proposed for Chestnut Street that would have required removal of a residence of historic character, replacing it with a new, generic commercial structure and a typical street-frontage parking lot. Residents were concerned, and public discourse in the local newspaper and at Town Hall led to withdrawal of the proposal. Village leadership felt that it was time to explore the historic character and economic future of the downtown district, and establish policy that could guide future decision making for the downtown

Assessing the Feasibility of an Aerotropolis Around Cleveland Hopkins International Airport, Executive Report

This report provides an assessment of the feasibility of developing an aerotropolis around Cleveland Hopkins International Airport, Cleveland, Ohio. The report describes the methodology used to assess the feasibility, notes the needs and expectations of community stakeholders, profiles the challenges and successes of six emerging and potential U.S. aerotropolises, and discusses the operating experiences and challenges of 12 additional U.S. airports. Further, this report describes the demographic and economic aspects of the study cities, and discusses potential target industry opportunities. The findings suggest that it is feasible to develop CLE as an aerotropolis, and that CLE may not be suited for an aerotropolis as practiced at other domestic and international airports. Rather, the concept itself may be the platform for moving forward with a defined, staged strategy for development surrounding CLE and should be viewed as an opportunity to develop the concept to specifically fit the region and its economic circumstance

Assessing the Feasibility of an Aerotropolis Around Cleveland Hopkins International Airport, Executive Report

This report provides an assessment of the feasibility of developing an aerotropolis around Cleveland Hopkins International Airport, Cleveland, Ohio. The report describes the methodology used to assess the feasibility, notes the needs and expectations of community stakeholders, profiles the challenges and successes of six emerging and potential U.S. aerotropolises, and discusses the operating experiences and challenges of 12 additional U.S. airports. Further, this report describes the demographic and economic aspects of the study cities, and discusses potential target industry opportunities. The findings suggest that it is feasible to develop CLE as an aerotropolis, and that CLE may not be suited for an aerotropolis as practiced at other domestic and international airports. Rather, the concept itself may be the platform for moving forward with a defined, staged strategy for development surrounding CLE and should be viewed as an opportunity to develop the concept to specifically fit the region and its economic circumstance

Health, education, and social care provision after diagnosis of childhood visual disability

Aim: To investigate the health, education, and social care provision for children newly diagnosed with visual disability.Method: This was a national prospective study, the British Childhood Visual Impairment and Blindness Study 2 (BCVIS2), ascertaining new diagnoses of visual impairment or severe visual impairment and blindness (SVIBL), or equivalent vi-sion. Data collection was performed by managing clinicians up to 1-year follow-up, and included health and developmental needs, and health, education, and social care provision.Results: BCVIS2 identified 784 children newly diagnosed with visual impairment/SVIBL (313 with visual impairment, 471 with SVIBL). Most children had associated systemic disorders (559 [71%], 167 [54%] with visual impairment, and 392 [84%] with SVIBL). Care from multidisciplinary teams was provided for 549 children (70%). Two-thirds (515) had not received an Education, Health, and Care Plan (EHCP). Fewer children with visual impairment had seen a specialist teacher (SVIBL 35%, visual impairment 28%, χ2p < 0.001), or had an EHCP (11% vs 7%, χ2p < 0 . 01).Interpretation: Families need additional support from managing clinicians to access recommended complex interventions such as the use of multidisciplinary teams and educational support. This need is pressing, as the population of children with visual impairment/SVIBL is expected to grow in size and complexity.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant

Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls

Background The risk factors for recovery from COVID-19 dyspnoea are poorly understood. We investigated determinants of recovery from dyspnoea in adults with COVID-19 and compared these to determinants of recovery from non-COVID-19 dyspnoea. Methods We used data from two prospective cohort studies: PHOSP-COVID (patients hospitalised between March 2020 and April 2021 with COVID-19) and COVIDENCE UK (community cohort studied over the same time period). PHOSP-COVID data were collected during hospitalisation and at 5-month and 1-year follow-up visits. COVIDENCE UK data were obtained through baseline and monthly online questionnaires. Dyspnoea was measured in both cohorts with the Medical Research Council Dyspnoea Scale. We used multivariable logistic regression to identify determinants associated with a reduction in dyspnoea between 5-month and 1-year follow-up. Findings We included 990 PHOSP-COVID and 3309 COVIDENCE UK participants. We observed higher odds of improvement between 5-month and 1-year follow-up among PHOSP-COVID participants who were younger (odds ratio 1.02 per year, 95% CI 1.01–1.03), male (1.54, 1.16–2.04), neither obese nor severely obese (1.82, 1.06–3.13 and 4.19, 2.14–8.19, respectively), had no pre-existing anxiety or depression (1.56, 1.09–2.22) or cardiovascular disease (1.33, 1.00–1.79), and shorter hospital admission (1.01 per day, 1.00–1.02). Similar associations were found in those recovering from non-COVID-19 dyspnoea, excluding age (and length of hospital admission). Interpretation Factors associated with dyspnoea recovery at 1-year post-discharge among patients hospitalised with COVID-19 were similar to those among community controls without COVID-19. Funding PHOSP-COVID is supported by a grant from the MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19. The views expressed in the publication are those of the author(s) and not necessarily those of the National Health Service (NHS), the NIHR or the Department of Health and Social Care. COVIDENCE UK is supported by the UK Research and Innovation, the National Institute for Health Research, and Barts Charity. The views expressed are those of the authors and not necessarily those of the funders