La bibliothèque sans bibliothécaire: l'autogestion comme outil de communication à la Cité du Genévrier

La Cité du Genévrier, située à Saint-Légier sur Vevey, dans le canton de Vaud, est une institution qui accueille des personnes physiquement et/ou mentalement polyhandicapées. Cet établissement fait partie de la Fondation Eben-Hezer qui compte également deux institutions-soeurs, les Maisons des Chavannes et le Home Salem. Un nouveau bâtiment a été construit; il accueillera notamment l’administration de l’institution. La bibliothèque y disposera d’un local bien éclairé, à proximité directe de la réception. A l’occasion du déménagement s’est posée la question suivante : cela vaut-il la peine de déménager la bibliothèque, ou le moment est-il venu de la supprimer? Le changement de lieu est présenté comme une opportunité de régler définitivement le problème de sa gestion. Nous avons donc été mandatées pour juger de l’utilité ou non de la bibliothèque d’après les besoins des collaborateurs, puis pour élaborer des scenarii, qui puissent être présentés au Conseil de direction. Tels sont les objectifs généraux fixés au départ

Lead Generation: Sowing the Seeds for Future Success

Lead generation and the associated hit-to-lead process are key strategic elements in modern pharmaceutical research, and most companies have implemented this concept. Efficient lead generation is one of the main attempts to reduce the high attrition rates observed along the drug discovery process by focussing on the early developmental phases. The level of integration of the lead generation activities within the discovery organization, the flexibility in assessing and implementing new chemistries and new technologies, the high-quality standards set for the identification of the best possible chemical lead series will ultimately determine the future success in discovering new medicines

2-Styryl-pyridines and 2-(3,4-Dihydro-naphthalen-2-yl)pyridines as Potent NR1/2B Subtype Selective NMDA Receptor Antagonists

A series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists that are selective (vs. ?1 and M1 receptors) and are active in vivo

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Schulte-Schrepping J, Reusch N, Paclik D, et al. Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell. 2020;182(6):1419-1440.e23.Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DRhiCD11chi inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19