Differences in Left and Right Laparoscopic Adrenalectomy

Although no difference was found in complications or conversion rates for either right or left laparoscopic adrenalectomy, the authors report that lower blood loss and decreased operative time were noted with laparoscopic right adrenalectomy

Genomic structural variations lead to dysregulation of important coding and non-coding RNA species in dilated cardiomyopathy

The transcriptome needs to be tightly regulated by mechanisms that include transcription factors, enhancers, and repressors as well as non-coding RNAs. Besides this dynamic regulation, a large part of phenotypic variability of eukaryotes is expressed through changes in gene transcription caused by genetic variation. In this study, we evaluate genome-wide structural genomic variants (SVs) and their association with gene expression in the human heart. We detected 3,898 individual SVs affecting all classes of gene transcripts (e.g., mRNA, miRNA, lncRNA) and regulatory genomic regions (e.g., enhancer or TFBS). In a cohort of patients (n = 50) with dilated cardiomyopathy (DCM), 80,635 non-protein-coding elements of the genome are deleted or duplicated by SVs, containing 3,758 long non-coding RNAs and 1,756 protein-coding transcripts. 65.3% of the SV-eQTLs do not harbor a significant SNV-eQTL, and for the regions with both classes of association, we find similar effect sizes. In case of deleted protein-coding exons, we find downregulation of the associated transcripts, duplication events, however, do not show significant changes over all events. In summary, we are first to describe the genomic variability associated with SVs in heart failure due to DCM and dissect their impact on the transcriptome. Overall, SVs explain up to 7.5% of the variation of cardiac gene expression, underlining the importance to study human myocardial gene expression in the context of the individual genome. This has immediate implications for studies on basic mechanisms of cardiac maladaptation, biomarkers, and (gene) therapeutic studies alike

A Wireless, Reconfigurable, Multichannel Potentiostat for Wearable Electrochemical Biosensing Applications

Wearable chemical sensing technology shows promise as a convenient method for continuously and non-invasively monitoring physiological parameters via biochemical markers such as glucose, lactate, and alcohol. Measuring these biomarkers from easily accessible biological fluids (e.g. sweat, saliva, and interstitial fluid) can provide a more comprehensive view of one’s health and fitness compared to other biosensing techniques, such as motion sensing and electrophysiological signal recording. Extracting this physiochemical data in real-time is possible through wearable devices formed by integrating electrochemical biosensors with low power electronics. This thesis provides an overview of how these electronics are developed, presents a realized design, and demonstrates the design’s successful integration with a wearable sensor to create an electrochemical biosensing system

Bronchiale und pulmonale Szintigraphie mit radioaktiv markierten Aerosolen

SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman