49 research outputs found
Quantitative Histomorphometry of the Healthy Peritoneum
The peritoneum plays an essential role in preventing abdominal frictions and
adhesions and can be utilized as a dialysis membrane. Its physiological
ultrastructure, however, has not yet been studied systematically. 106
standardized peritoneal and 69 omental specimens were obtained from 107
patients (0.1–60 years) undergoing surgery for disease not affecting the
peritoneum for automated quantitative histomorphometry and
immunohistochemistry. The mesothelial cell layer morphology and protein
expression pattern is similar across all age groups. Infants below one year
have a thinner submesothelium; inflammation, profibrotic activity and
mesothelial cell translocation is largely absent in all age groups. Peritoneal
blood capillaries, lymphatics and nerve fibers locate in three distinct
submesothelial layers. Blood vessel density and endothelial surface area
follow a U-shaped curve with highest values in infants below one year and
lowest values in children aged 7–12 years. Lymphatic vessel density is much
lower, and again highest in infants. Omental blood capillary density
correlates with parietal peritoneal findings, whereas only few lymphatic
vessels are present. The healthy peritoneum exhibits major thus far unknown
particularities, pertaining to functionally relevant structures, and subject
to substantial changes with age. The reference ranges established here provide
a framework for future histomorphometric analyses and peritoneal transport
modeling approaches
Advanced Parameters of Cardiac Mechanics in Children With Chronic Kidney Disease (CKD): a Preliminary Report From the Cardiovascular Comorbidity in Children with CKD (4C) Study
WOS: 000321387201079
SOLUBLE UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR (SUPAR) SERUM LEVELS PREDICT PROGRESSION OF KIDNEY DISEASE IN CHILDREN
WOS: 000408418900043