A Scanned Perturbation Technique For Imaging Electromagnetic Standing Wave Patterns of Microwave Cavities

We have developed a method to measure the electric field standing wave distributions in a microwave resonator using a scanned perturbation technique. Fast and reliable solutions to the Helmholtz equation (and to the Schrodinger equation for two dimensional systems) with arbitrarily-shaped boundaries are obtained. We use a pin perturbation to image primarily the microwave electric field amplitude, and we demonstrate the ability to image broken time-reversal symmetry standing wave patterns produced with a magnetized ferrite in the cavity. The whole cavity, including areas very close to the walls, can be imaged using this technique with high spatial resolution over a broad range of frequencies.Comment: To be published in Review of Scientific Instruments,September, 199

BlockDrop: Dynamic Inference Paths in Residual Networks

Very deep convolutional neural networks offer excellent recognition results, yet their computational expense limits their impact for many real-world applications. We introduce BlockDrop, an approach that learns to dynamically choose which layers of a deep network to execute during inference so as to best reduce total computation without degrading prediction accuracy. Exploiting the robustness of Residual Networks (ResNets) to layer dropping, our framework selects on-the-fly which residual blocks to evaluate for a given novel image. In particular, given a pretrained ResNet, we train a policy network in an associative reinforcement learning setting for the dual reward of utilizing a minimal number of blocks while preserving recognition accuracy. We conduct extensive experiments on CIFAR and ImageNet. The results provide strong quantitative and qualitative evidence that these learned policies not only accelerate inference but also encode meaningful visual information. Built upon a ResNet-101 model, our method achieves a speedup of 20\% on average, going as high as 36\% for some images, while maintaining the same 76.4\% top-1 accuracy on ImageNet.Comment: CVPR 201

An Object-Based Approach to Implementing Distributed Concurrency Control

We have added distributed concurrency control to the MELD object system by representing in progress transactions as simulated objects. Transaction objects exploit MELD‘s normal message passing facilities to support the concurrency control mechanism. We have completed the implementation of an optimistic mechanism using transaction objects and have designed a two phase locking mechanism based on the same paradigm. We discuss the tradeoffs made and lessons learned, dealing both with transactions on objects and with transactions as objects

Evolution of substrate-specific gene expression and RNA editing in brown rot wood-decaying fungi.

Fungi that decay wood have characteristic associations with certain tree species, but the mechanistic bases for these associations are poorly understood. We studied substrate-specific gene expression and RNA editing in six species of wood-decaying fungi from the 'Antrodia clade' (Polyporales, Agaricomycetes) on three different wood substrates (pine, spruce, and aspen) in submerged cultures. We identified dozens to hundreds of substrate-biased genes (i.e., genes that are significantly upregulated in one substrate relative to the other two substrates) in each species, and these biased genes are correlated with their host ranges. Evolution of substrate-biased genes is associated with gene family expansion, gain and loss of genes, and variation in cis- and trans- regulatory elements, rather than changes in protein coding sequences. We also demonstrated widespread RNA editing events in the Antrodia clade, which differ from those observed in the Ascomycota in their distribution, substitution types, and the genomic environment. Moreover, we found that substrates could affect editing positions and frequency, including editing events occurring in mRNA transcribed from wood-decay-related genes. This work shows the extent to which gene expression and RNA editing differ among species and substrates, and provides clues into mechanisms by which wood-decaying fungi may adapt to different hosts

Nowhere to Run; Nowhere to Hide: The Reality of Being a Law Library Director in Times of Great Opportunity and Significant Challenges

This is an edited version of remarks presented at \u27Nowhere to Run, Nowhere to Hide\u27: The Reality of Being a Law Library Director in Times of Great Opportunity and Significant Challenges, January 5, 2015, at the Association of American Law Schools Annual Meeting, Washington, D.C

The MELD Programming Language: User Manual

This manual is divided into two parts, a tutorial introduction to the MELD programming language, and a language reference manual. The index spans both parts. A bibliography of MELD publications and technical reports is available in Appendix II. If you are interested in the decisions leading to the current design you should refer to this literature; the intent of this manual is to provide a working description of the current language and its implementation, and not an exposition of the language issues. Chapter 9 describes the language features which are not yet implemented

MELDing Multiple Granularities of Parallelism

We are developing an experimental programming language, MELD, that supports a range of concurrent styles by supporting multiple programming paradigms at multiple levels of granularity. MELD integrates three granularities of parallelism: macro dataflow among statements within a method or among methods for fine grain concurrency, synchronous or asynchronous message passing among local or remote objects for medium grain concurrency, and transactions for large grain concurrency among users

Non-Invasive Photoacoustic Imaging of In Vivo Mice with Erythrocyte Derived Optical Nanoparticles to Detect CAD/MI.

Coronary artery disease (CAD) causes mortality and morbidity worldwide. We used near-infrared erythrocyte-derived transducers (NETs), a contrast agent, in combination with a photoacoustic imaging system to identify the locations of atherosclerotic lesions and occlusion due to myocardial-infarction (MI). NETs (≈90 nm diameter) were fabricated from hemoglobin-depleted mice erythrocyte-ghosts and doped with Indocyanine Green (ICG). Ten weeks old male C57BL/6 mice (n = 9) underwent left anterior descending (LAD) coronary artery ligation to mimic vulnerable atherosclerotic plaques and their rupture leading to MI. 150 µL of NETs (20 µM ICG,) was IV injected via tail vein 1-hour prior to photoacoustic (PA) and fluorescence in vivo imaging by exciting NETs at 800 nm and 650 nm, respectively. These results were verified with histochemical analysis. We observed ≈256-fold higher PA signal from the accumulated NETs in the coronary artery above the ligation. Fluorescence signals were detected in LAD coronary, thymus, and liver. Similar signals were observed when the chest was cut open. Atherosclerotic lesions exhibited inflammatory cells. Liver demonstrated normal portal tract, with no parenchymal necrosis, inflammation, fibrosis, or other pathologic changes, suggesting biocompatibility of NETs. Non-invasively detecting atherosclerotic plaques and stenosis using NETs may lay a groundwork for future clinical detection and improving CAD risk assessment

Tunable Membranes for Free-Flow Zone Electrophoresis in PDMS Microchip Using Guided Self-Assembly of Silica Microbeads

In this paper, we evaluate the strategy of using self-assembled microbeads to build a robust and tunable membrane for free-flow zone electrophoresis in a PDMS microfluidic chip. To fabricate a porous membrane as a salt bridge for free-flow zone electrophoresis, we used silica or polystyrene microbeads between 3–6 μm in diameter and packed them inside a microchannel. After complete evaporation, we infiltrated the porous microbead structure with a positively or negatively charged hydrogel to modify its surface charge polarity. Using this device, we demonstrated binary sorting (separation of positive and negative species at a given pH) of peptides and dyes in standard buffer systems without using sheath flows. The sample loss during sorting could be minimized by using ion selectivity of hydrogel-infiltrated microbead membranes. Our fabrication method enables building a robust membrane for pressure-driven free-flow zone electrophoresis with tunable pore size as well as surface charge polarity.National Institutes of Health (U.S.) (R21 EB008177-01A2)National Institutes of Health (U.S.) (P30-ES002109