Data-level hybrid strategy selection for disk fault prediction model based on multivariate GAN

Data class imbalance is a common problem in classification problems, where minority class samples are often more important and more costly to misclassify in a classification task. Therefore, it is very important to solve the data class imbalance classification problem. The SMART dataset exhibits an evident class imbalance, comprising a substantial quantity of healthy samples and a comparatively limited number of defective samples. This dataset serves as a reliable indicator of the disc's health status. In this paper, we obtain the best balanced disk SMART dataset for a specific classification model by mixing and integrating the data synthesised by multivariate generative adversarial networks (GAN) to balance the disk SMART dataset at the data level; and combine it with genetic algorithms to obtain higher disk fault classification prediction accuracy on a specific classification model

Branqueamento em ambulatório de dentes pigmentados por tetraciclina: caso clínico

Tese de mestrado, Medicina Dentária, Universidade de Lisboa, Faculdade de Medicina Dentária, 2011A alteração da cor dentária causada por tetraciclina representa uma preocupação estética tremenda para os pacientes e o seu tratamento é em muitos casos desafiantes. A literatura refere que estas pigmentações respondem positivamente ao branqueamento dentário prolongando o tempo de tratamento. Assim o branqueamento pode ser um método alternativo e conservador, válido para melhorar a estética dentária. No entanto, existem poucos estudos clínicos sobre este tema. Objectivo: Apresentação de um caso clínico de pigmentação dentária por tetraciclinas, com uma breve revisão bibliográfica, opções de tratamento, tratamento realizado e discussão dos resultados. Materiais e Métodos: Paciente com pigmentação dentária por tetraciclina, de grau moderada a severa, foi tratado com o branqueamento em ambulatório nocturno usando 10% de peróxido de carbamida (Opalescence 10% PF Regular – Ultradent Product, Inc, South Jordan, UT, USA) durante seis meses. O paciente foi instruído a aplicar gel branqueador nas moldeiras individuais e utilizá-las 6 a 8 horas à noite durante o sono e registar diariamente a sensibilidade dentária e gengival numa escala visual analógica. A avaliação da cor através da escala de cores Vitapan Classical e o registo fotográfico foram realizados aos 7 dias e 14 dias de tratamento, depois mensalmente e às duas semanas após conclusão do branqueamento. Resultados: Foi obtido melhoria de 13, 14 e 12 unidades de cor e 100%, 93% e 92% de sucesso nos terços incisal, médio e cervical após seis meses de branqueamento dentário. O aumento da sensibilidade dentária ocorrido durante o tratamento foi ligeiro e bem tolerado, extinguiu-se dentro de duas semanas após fim do branqueamento. Conclusão: O branqueamento nocturno com 10% de peróxido de carbamida em seis meses revelou-se ser eficaz na remoção de pigmentação de tetraciclina moderada a severa.The tooth discoloration caused by tetracycline is a tremendous aesthetic concern for patients and the management of these cases is often challenging. The literature shows that tetracycline staining respond positively to tooth bleaching by extending treatment time, thus bleaching may be a valid conservative alternative to improve dental aesthetic. However, there are few clinical studies of this topic. Objective: Present a clinical case of tetracycline-stained tooth, with a brief literature review, treatment options, performed treatment and discussion of results. Material and methods: The patient with moderate to severe tetracycline-stained teeth was treated by six months at-home overnight bleaching using 10% carbamide peroxide (Opalescence 10% PF Regular – Ultradent Product, Inc, South Jordan, UT, USA) The patient was instructed to place bleaching gel into the trays and wear 6 to 8 hours while sleeping at night and record daily tooth and gingival sensitivity on a visual analogue scale. The evaluation of color with Vitapan Classical shade guide and photographic records were done at 7 days and 14 days of treatment, then monthly and two weeks after bleaching. Results: 13, 14 and 12 units of color change and 100%, 93% and 92% of success rate in the incisal, middle and cervical thirds were obtained after six months of tooth bleaching. The increase of tooth sensitivity occurred during treatment were mild and well tolerated, it was extinguished within two weeks after bleaching. Conclusion: The six months at-home overnight bleaching using 10% carbamide peroxide revealed to be effective in removing moderate to severe tetracycline staining

A Survey of Methods for Handling Disk Data Imbalance

Class imbalance exists in many classification problems, and since the data is designed for accuracy, imbalance in data classes can lead to classification challenges with a few classes having higher misclassification costs. The Backblaze dataset, a widely used dataset related to hard discs, has a small amount of failure data and a large amount of health data, which exhibits a serious class imbalance. This paper provides a comprehensive overview of research in the field of imbalanced data classification. The discussion is organized into three main aspects: data-level methods, algorithmic-level methods, and hybrid methods. For each type of method, we summarize and analyze the existing problems, algorithmic ideas, strengths, and weaknesses. Additionally, the challenges of unbalanced data classification are discussed, along with strategies to address them. It is convenient for researchers to choose the appropriate method according to their needs

Phosphodiesterase type 5 inhibitors and risk of melanoma: A meta-analysis

Background The association between phosphodiesterase type 5 (PDE5) inhibitors and melanoma risk is controversial. Objective We quantify the association between use of PDE5 inhibitors and melanoma. Methods We systematically searched PubMed, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, and ClinicalTrials.gov for studies that were conducted up to July 13, 2016, and evaluated the association between PDE5 inhibitors and skin cancer. Random effects meta-analyses were used to calculate the adjusted odds ratio (OR) with the 95% confidence interval (CI). Results Five observational studies were included. Compared with PDE5 inhibitor nonuse, PDE5 inhibitor use was slightly but significantly associated with an increased risk for development of melanoma (OR, 1.12; 95% CI, 1.03-1.21) and basal cell carcinoma (OR, 1.14; 95% CI, 1.09-1.19) but not squamous cell carcinoma. For melanoma risk, none of the prespecified factors (dose of PDE5 inhibitor, study design, and study region) significantly affected the results (P > .05). Our sensitivity analysis confirmed the stability of the results. Limitations We included only observational studies, which had some heterogeneities and inconsistent controlling for potential confounders. Conclusions Use of PDE5 inhibitors may be associated with a slightly increased risk for development of melanoma and basal cell carcinoma but not squamous cell carcinoma. However, further large well-conducted prospective studies with adequate adjustment for potential confounders are required for confirmation

Analysis of a heterogeneous SEIRS patch model with asymmetric mobility kernel

In this paper, we establish a spatial heterogeneous SEIRS patch model with asymmetric mobility kernel. The basic reproduction ratio $\mathcal{R}_{0}$ is defined, and threshold-type results on global dynamics are investigated in terms of $\mathcal{R}_{0}$. In certain cases, the monotonicity of $\mathcal{R}_{0}$ with respect to the heterogeneous diffusion coefficients is established, but this is not true in all cases. Finally, when the diffusion rate of susceptible individuals approaches zero, the long-term behavior of the endemic equilibrium is explored. In contrast to most prior studies, which focused primarily on the mobility of susceptible and symptomatic infected individuals, our findings indicate the significance of the mobility of exposed and recovered persons in disease dynamics

Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study.

ObjectivesIn a genome-wide association study, we discovered chromosome 12q15 (defined as rs73329476) as a silica-related pneumoconiosis susceptibility region. However, the causal variants in this region have not yet been reported.MethodsWe systematically screened eight potentially functional single-neucleotide polymorphism (SNPs) in the genes near rs73329476 (carboxypeptidase M (CPM) and cleavage and polyadenylation specific factor 6 (CPSF6)) in a case-control study including 177 cases with silicosis and 204 healthy controls, matched to cases with years of silica dust exposure. We evaluated the associations between these eight SNPs and the development of silicosis. Luciferase reporter gene assays were performed to test the effects of selected SNP on the activity of CPM in the promoter. In addition, a two-stage case-control study was performed to investigate the expression differences of the two genes in peripheral blood leucocytes from a total of 64 cases with silicosis and 64 healthy controls with similar years of silica dust exposure as the cases.ResultsWe found a strong association between the mutant rs12812500 G allele and the susceptibility of silicosis (OR=1.45, 95% CI 1.03 to 2.04, p=0.034), while luciferase reporter gene assays indicated that the mutant G allele of rs12812500 is strongly associated with increased luciferase levels compared with the wild-type C allele (p<0.01). Moreover, the mRNA (peripheral blood leucocytes) expression of the CPM gene was significantly higher in subjects with silicosis compared with healthy controls.ConclusionsThe rs12812500 variant of the CPM gene may increase silicosis susceptibility by affecting the expression of CPM, which may contribute to silicosis susceptibility with biological plausibility