BACONE COLLEGE A HISTORY

This thesis is a study of the founding and continued growth of Bacone College The school now located just outside of Muskogee J Oklahoma, was originally started at Tahlequah I Indian Territory, in 1880. It was commissioned under the name, Indian University and well it was because the Indian was the prime cause for the institution, In 1885 the University was moved from Tahlequah to the present location at Muskogee. Bacone, pronounced (Bay-Cone), College replaced the name Indian University in 1910 when the board decided to rename the college in honor of its founder Almon C. Bacon

Typing African Relapsing Fever Spirochetes

Sequencing distinguished relapsing fever from other borrelial species but not B. duttonii from B. recurrentis

Typing African Relapsing Fever Spirochetes

Relapsing fever Borrelia spp. challenge microbiologic typing because they possess segmented genomes that maintain essential genes on large linear plasmids. Antigenic variation further complicates typing. Intergenic spacer (IGS, between 16S–23S genes) heterogeneity provides resolution among Lyme disease–associated and some relapsing fever spirochetes. We used an IGS fragment for typing East African relapsing fever Borrelia spp. Borrelia recurrentis and their louse vectors showed 2 sequence types, while 4 B. duttonii and their tick vectors had 4 types. IGS typing was unable to discriminate between the tick- and louseborne forms of disease. B. crocidurae, also present in Africa, was clearly resolved from the B. recurrentis/B. duttonii complex. IGS analysis of ticks showed relapsing fever Borrelia spp. and a unique clade, distant from those associated with relapsing fever, possibly equivalent to a novel species in ticks from this region. Clinical significance of this spirochete is undetermined

Solar UV radiation in Saint-Denis, La Réunion and Cape Town, South Africa: 10 years climatology and human exposure assessment at altitude

International audienceSolar ultraviolet radiation (UVR) monitoring is important since it depends on several atmospheric parameters which are associated with climate change and since excess solar UVR exposure and has significant impacts on human health and wellbeing. The objective of this study was to investigate the trends in solar UVR during a decade (2009-2018) in Saint-Denis, Reunion Island (20.9°S, 55.5°E, 85 m ASL) and Cape Town, South Africa (33.97°S, 18.6°E, 42 m ASL). This comparison was done using total daily erythema exposure as derived from UVR sensors continuously at both sites. Climatology over the 10-year period showed extreme UVR exposure for both sites. Slight changes with opposite trends were found, +3.6% at Saint-Denis and −3.7% at Cape Town. However, these two sites often experience extreme weather conditions thereby making the trend evaluation difficult. Human exposure assessment was performed for hiking activities at two popular high-altitude hiking trails on the Maïdo-Grand Bénare (Reunion) and Table Mountain (Cape Town) with a handheld radiometer. Extreme exposure doses of 64 SED and 40 SED (Standard Erythemal Dose, 1 SED = 100 J.m −2) were recorded, respectively. These high exposure doses highlight the importance of raising public awareness on the risk related to excess UVR exposure at tourist sites, especially those at high altitude

First radial velocity results from the MINiature Exoplanet Radial Velocity Array (MINERVA)

The MINiature Exoplanet Radial Velocity Array (MINERVA) is a dedicated observatory of four 0.7m robotic telescopes fiber-fed to a KiwiSpec spectrograph. The MINERVA mission is to discover super-Earths in the habitable zones of nearby stars. This can be accomplished with MINERVA's unique combination of high precision and high cadence over long time periods. In this work, we detail changes to the MINERVA facility that have occurred since our previous paper. We then describe MINERVA's robotic control software, the process by which we perform 1D spectral extraction, and our forward modeling Doppler pipeline. In the process of improving our forward modeling procedure, we found that our spectrograph's intrinsic instrumental profile is stable for at least nine months. Because of that, we characterized our instrumental profile with a time-independent, cubic spline function based on the profile in the cross dispersion direction, with which we achieved a radial velocity precision similar to using a conventional "sum-of-Gaussians" instrumental profile: 1.8 m s$^{-1}$ over 1.5 months on the RV standard star HD 122064. Therefore, we conclude that the instrumental profile need not be perfectly accurate as long as it is stable. In addition, we observed 51 Peg and our results are consistent with the literature, confirming our spectrograph and Doppler pipeline are producing accurate and precise radial velocities.Comment: 22 pages, 9 figures, submitted to PASP, Peer-Reviewed and Accepte

The stories we tell: uncanny encounters in Mr Straw’s house

During my first visit to Mr Straw’s House, a National Trust Property in the North of England, I was intrigued by the discrepancies between the narrative framework provided by the National Trust – its exclusions, silences and invisibilities – and the far more complex stories the house seemed to tantalisingly hint at. As a scholar I am drawn to certain sites and affectively engage with them and yet I usually keep silent about my investment which informs not only my interest but also how I read these heritage sites. My aim here is not primarily to interrogate my own investment, but to ask how productive it is, what it enables me to see and to describe and where its limits are. This case study explores a particular tourist attraction from the perspective of storytelling and asks what narratives can be constructed around, and generated through, the spatial-emotional dimensions of this heritage site. I am interested in the hold sites have over people, why and how they provoke imaginative and empathic investment that generates a network of stories and triggers processes of unravelling which have the potential to transform silences and unmetabolised affect into empathy and emotional thought

First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial

BACKGROUND: Org 25435 is a new water-soluble alpha-amino acid ester intravenous anaesthetic which proved satisfactory in animal studies. This study aimed to assess the safety, tolerability and efficacy of Org 25435 and to obtain preliminary pharmacodynamic and pharmacokinetic data. METHODS: In the Short Infusion study 8 healthy male volunteers received a 1 minute infusion of 0.25, 0.5, 1.0, or 2.0 mg/kg (n = 2 per group); a further 10 received 3.0 mg/kg (n = 5) or 4.0 mg/kg (n = 5). Following preliminary pharmacokinetic modelling 7 subjects received a titrated 30 minute Target Controlled Infusion (TCI), total dose 5.8-20 mg/kg. RESULTS: Within the Short Infusion study, all subjects were successfully anaesthetised at 3 and 4 mg/kg. Within the TCI study 5 subjects were anaesthetised and 2 showed signs of sedation. Org 25435 caused hypotension and tachycardia at doses over 2 mg/kg. Recovery from anaesthesia after a 30 min administration of Org 25435 was slow (13.7 min). Pharmacokinetic modelling suggests that the context sensitive half-time of Org 25435 is slightly shorter than that of propofol in infusions up to 20 minutes but progressively longer thereafter. CONCLUSIONS: Org 25435 is an effective intravenous anaesthetic in man at doses of 3 and 4 mg/kg given over 1 minute. Longer infusions can maintain anaesthesia but recovery is slow. Hypotension and tachycardia during anaesthesia and slow recovery of consciousness after cessation of drug administration suggest this compound has no advantages over currently available intravenous anaesthetics