Simulating Radiative Magnetohydrodynamical Flows with AstroBEAR: Implementation and Applications of Non-equilibrium Cooling

Radiative cooling plays a crucial role in the dynamics of many astrophysical flows, and is particularly important in the dense shocked gas within Herbig-Haro (HH) objects and stellar jets. Simulating cooling processes accurately is necessary to compare numerical simulations with existing and planned observations of HH objects, such as those from the Hubble Space Telescope and the James Webb Space Telescope. In this paper we discuss a new, non-equilibrium cooling scheme we have implemented into the 3-D magnetohydrodynamic (MHD) code AstroBEAR. The new cooling function includes ionization, recombination, and excitation of all the important atomic species that cool below 10000 K. We tested the routine by comparing its predictions with those from the well-tested 1-D Cox-Raymond shock code (Raymond 1979). The results show thatAstroBEAR accurately tracks the ionization fraction, temperature, and other MHD variables for all low-velocity (.90 km/s) magnetized radiative shock waves. The new routine allows us to predict synthetic emission maps in all the bright forbidden and permitted lines observed in stellar jets, including H{\alpha}, [NII], [OI], and [SII]. We present an example as to how these synthetic maps facilitate a direct comparison with narrowband images of HH objects.Comment: 8 figure

Rates of medial tibiofemoral joint space narrowing in osteoarthritis studies consistent despite methodological differences

SummaryRationaleMinimum tibiofemoral joint space width in the medial compartment (JSW) is the most well-established structural outcome measure for osteoarthritis (OA) of the knee. Its usefulness as a measure of therapeutic effectiveness in short-term studies is limited by the rate and variability of joint space narrowing (JSN) in the OA population. Microfocal radiography has been shown to improve reproducibility of JSW measurement compared to standard radiography, but measurement of magnification from microfocal knee films has been problematic, and JSN is yet to be investigated in a longitudinal microfocal study.ObjectiveTo establish the effect on JSW reproducibility of a new method of magnification measurement in microfocal radiographs. To report on and compare rates of medial tibiofemoral JSN and their variations in the placebo arms of microfocal and standard radiographic clinical trials in OA, using fluoroscopic semi-flexed (SF) knee positioning. To place in the context of published estimates of rates of JSN from comparable studies.MethodsUsing microfocal radiography, 36 patients were followed at a single centre for 2 years. Using standard radiography, 86 patients were followed for 1 year at a single centre, and 549 for 2 years in a multi-centre international study. Computerised JSW measurement was undertaken using enhanced and automated versions of existing algorithms. Rates of JSN were examined in the context of a review of published rates of JSN using a variety of techniques.ResultsReproducibility of JSW measurement from microfocal radiographs was improved by the new magnification measurement. Rates of JSN were similar across the studies, but more variable when using standard radiography. The rates of JSN were also consistent with those from previously published investigations; all estimates since 2000, bar one, being consistent with the value 0.05mm/year.ConclusionMicrofocal radiography using the new method lowered the variability of the rate of JSN, but the high cost and low availability of microfocal equipment remains a barrier to its more widespread use. The consistently low but highly variable rates of JSN seen in the review suggest that continued attempts to improve radiographic and mensural techniques are unlikely to significantly reduce required sample sizes

Constructive role of dissipation for driven coupled bosonic modes

We describe four cases of childhood B-cell progenitor acute lymphoblastic leukaemia (BCP-ALL) and one of T-cell (T-ALL) with unexpected numbers of interphase signals for ETV6 with an ETV6-RUNX1 fusion probe. Three fusion negative cases each had a telomeric part of 12p terminating within intron 2 of ETV6, attached to sequences from 5q, 7p and 7q, respectively. Two fusion positive cases, with partial insertions of ETV6 into chromosome 21, also had a breakpoint in intron 2. Fluorescence in situ hybridisation ( FISH), array comparative genomic hybridization (aCGH) and Molecular Copy-Number Counting (MCC) results were concordant for the T-cell case. Sequences downstream of TLX3 on chromosome 5 were deleted, leaving the intact gene closely apposed to the first two exons of ETV6 and its upstream promoter. qRT-PCR showed a significant upregulation of TLX3. In this study we provide the first incontrovertible evidence that the upstream promoter of ETV6 attached to the first two exons of the gene was responsible for the ectopic expression of a proto-oncogene that became abnormally close as the result of deletion and translocation. We have also shown breakpoints in intron 2 of ETV6 in two cases of insertion with ETV6-RUNX1 fusion

Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]

To determine the efficacy and safety of risedronate in patients with knee osteoarthritis (OA), the British study of risedronate in structure and symptoms of knee OA (BRISK), a 1-year prospective, double-blind, placebo-controlled study, enrolled patients (40–80 years of age) with mild to moderate OA of the medial compartment of the knee. The primary aims were to detect differences in symptoms and function. Patients were randomized to once-daily risedronate (5 mg or 15 mg) or placebo. Radiographs were taken at baseline and 1 year for assessment of joint-space width using a standardized radiographic method with fluoroscopic positioning of the joint. Pain, function, and stiffness were assessed using the Western Ontario and McMaster Universities (WOMAC) OA index. The patient global assessment and use of walking aids were measured and bone and cartilage markers were assessed. The intention-to-treat population consisted of 284 patients. Those receiving risedronate at 15 mg showed improvement of the WOMAC index, particularly of physical function, significant improvement of the patient global assessment (P < 0.001), and decreased use of walking aids relative to patients receiving the placebo (P = 0.009). A trend towards attenuation of joint-space narrowing was observed in the group receiving 15 mg risedronate. Eight percent (n = 7) of patients receiving placebo and 4% (n = 4) of patients receiving 5 mg risedronate exhibited detectable progression of disease (joint-space width ≥ 25% or ≥ 0.75 mm) versus 1% (n = 1) of patients receiving 15 mg risedronate (P = 0.067). Risedronate (15 mg) significantly reduced markers of cartilage degradation and bone resorption. Both doses of risedronate were well tolerated. In this study, clear trends towards improvement were observed in both joint structure and symptoms in patients with primary knee OA treated with risedronate

Quantum Lattice Solitons

The number state method is used to study soliton bands for three anharmonic quantum lattices: i) The discrete nonlinear Schr\"{o}dinger equation, ii) The Ablowitz-Ladik system, and iii) A fermionic polaron model. Each of these systems is assumed to have $f$-fold translational symmetry in one spatial dimension, where $f$ is the number of freedoms (lattice points). At the second quantum level $(n=2)$ we calculate exact eigenfunctions and energies of pure quantum states, from which we determine binding energy $(E_{\rm b})$, effective mass $(m^{*})$ and maximum group velocity $(V_{\rm m})$ of the soliton bands as functions of the anharmonicity in the limit $f \to \infty$. For arbitrary values of $n$ we have asymptotic expressions for $E_{\rm b}$, $m^{*}$, and $V_{\rm m}$ as functions of the anharmonicity in the limits of large and small anharmonicity. Using these expressions we discuss and describe wave packets of pure eigenstates that correspond to classical solitons.Comment: 21 pages, 1 figur

Resources for situated actions

In recent years, advances in software tools have made it easier to analyze interactive system specifications, and the range of their possible behaviors. However, the effort involved in producing the specifications of the system is still substantial, and a difficulty exists regarding the specification of plausible behaviors on the part of the user. Recent trends in technology towards more mobile and distributed systems further exacerbates the issue, as contextual factors come in to play, and less structured, more opportunistic behavior on the part of the user makes purely task-based analysis difficult. In this paper we consider a resourced action approach to specification and analysis. In pursuing this approach we have two aims - firstly, to facilitate a resource-based analysis of user activity, allowing resources to be distributed across a number of artifacts, and secondly to consider within the analysis a wider range of plausible and opportunistic user behaviors without a heavy specification overhead, or requiring commitment to detailed user models.We acknowledge with thanks EPSRC grant EP/F01404X/1 and FCT/FEDER grant POSC/EIA/56646/2004. Michael Harrison is grateful to colleagues in the ReSIST NoE (www.resit-noe.org)

Relationship Between Foliage Temperature and Water Stress in Potatoes

Field studies were conducted in southern Idaho to evaluate the possibility of using thermal infrared measurements of potato foliage to detect soil water deficits. Concurrent measurements of foliage-air temperature differences (Tf-Ta), leaf water potential (?leaf) and vapor pressure deficit (VPD) were obtained from differentially-irrigated Russet Burbank and Kennebec potatoes during the 1982 and 1983 growing seasons. Foliage-air temperature differences for well-watered potatoes were linearly related to VPD. Differences in Tf-Ta values between stressed and well-watered potatoes were relatively small in the early morning when evaporative demand was low. However, severe soil water deficits caused afternoon Tf-Ta values to rise as much as 8.0 C above non-stressed levels under conditions of high VPD. Foliage-air temperature differences and VPD data were used to construct a plant water stress index (PWSI) which reflected the rise in Tf-Ta, above non-stressed levels at a given VPD. The PWSI was linearly related to depressions in ?leaf caused by moderate to severe soil water deficits. However, the PWSI did not increase significantly above non-stressed values unless the soil matric potential ?soil fell below – 70 kPa (centibars). Since potatoes are normally irrigated before ?soil falls below – 60 kPa, it appears that foliage temperature measurements cannot be used to effectively schedule irrigation for this crop