Bedrock geology of the northern Columbia Plateau and adjacent areas

The Columbia Plateau is surrounded by a complex assemblage of highly deformed Precambrian to lower Tertiary continental and oceanic rocks that reflects numerous episodes of continental accretion. The plateau itself is comprised of the Columbia River basalt group formed between about 16.5 x 1 million years B.P. and 6 x 1 million years B.P. Eruptions were infrequent between about 14 and 6 x 1 million years B.P., allowing time for erosion and deformation between successive outpourings. The present-day courses of much of the Snake River, and parts of the Columbia River, across the plateau date from this time. Basalt produced during this waning activity is more heterogeneous chemically and isotopically than older flows, reflecting its prolonged period of volcanism

A statistical framework for testing functional categories in microarray data

Ready access to emerging databases of gene annotation and functional pathways has shifted assessments of differential expression in DNA microarray studies from single genes to groups of genes with shared biological function. This paper takes a critical look at existing methods for assessing the differential expression of a group of genes (functional category), and provides some suggestions for improved performance. We begin by presenting a general framework, in which the set of genes in a functional category is compared to the complementary set of genes on the array. The framework includes tests for overrepresentation of a category within a list of significant genes, and methods that consider continuous measures of differential expression. Existing tests are divided into two classes. Class 1 tests assume gene-specific measures of differential expression are independent, despite overwhelming evidence of positive correlation. Analytic and simulated results are presented that demonstrate Class 1 tests are strongly anti-conservative in practice. Class 2 tests account for gene correlation, typically through array permutation that by construction has proper Type I error control for the induced null. However, both Class 1 and Class 2 tests use a null hypothesis that all genes have the same degree of differential expression. We introduce a more sensible and general (Class 3) null under which the profile of differential expression is the same within the category and complement. Under this broader null, Class 2 tests are shown to be conservative. We propose standard bootstrap methods for testing against the Class 3 null and demonstrate they provide valid Type I error control and more power than array permutation in simulated datasets and real microarray experiments.Comment: Published in at http://dx.doi.org/10.1214/07-AOAS146 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

Two-body anticorrelation in a harmonically trapped ideal Bose gas

We predict the existence of a dip below unity in the second-order coherence function of a partially condensed ideal Bose gas in harmonic confinement, signaling the anticorrelation of density fluctuations in the sample. The dip in the second-order coherence function is revealed in a canonical-ensemble calculation, corresponding to a system with fixed total number of particles. In a grand-canonical ensemble description, this dip is obscured by the occupation-number fluctuation catastrophe of the ideal Bose gas. The anticorrelation is most pronounced in highly anisotropic trap geometries containing small particle numbers. We explain the fundamental physical mechanism which underlies this phenomenon, and its relevance to experiments on interacting Bose gases.Comment: 10 pages, 5 figures. v2: Minor changes and corrections to figures and text. To appear in PR

A Third Planet Orbiting HIP 14810

We present new precision radial velocities and a three-planet Keplerian orbit fit for the V = 8.5, G5 V star HIP 14810. We began observing this star at Keck Observatory as part of the N2K Planet Search Project. Wright et al. (2007) announced the inner two planets to this system, and subsequent observations have revealed the outer planet planet and the proper orbital solution for the middle planet. The planets have minimum masses of 3.9, 1.3, and 0.6 M_Jup and orbital periods of 6.67, 147.7, and 952 d, respectively. We have numerically integrated the family of orbital solutions consistent with the data and find that they are stable for at least 10^6 yr. Our photometric search shows that the inner planet does not transit.Comment: ApJL, accepte