Hydraulic Model Study: Saint Joseph Harbor Lighthouse Marina Project Investigation

https://deepblue.lib.umich.edu/bitstream/2027.42/154170/1/39015099114970.pd

The interface between arts practice and research: Attitudes and perceptions of Australian artist-academics

Whilst an academic working in the arts may have been appointed as a consequence of artistic accomplishment and a capacity to teach, the research that underpins such work is an intrinsic part of its production and also needs to be recognised. In Australia, the ability of the artist-academic to translate research into a form that is respected and rewarded is an issue of contention. This paper gathers responses to this issue. Perceptions of and attitudes to creative work as research are canvassed alongside life decisions arising from those perceptions and attitudes. This research occurs in the context of a new Australian framework for the evaluation of research. This framework offers some recognition of the research that supports creative practice. Thus, the long-standing experience of compromise reported by the Australian artist-academics interviewed for this study are discussed alongside new policies that seek to construct methodologies for its amelioration

Hydraulic Model Study: Wyandotte Wastewater Treatment Plant Influent Pump Station Wet Well

https://deepblue.lib.umich.edu/bitstream/2027.42/154185/1/39015101405044.pd

Prevalence and correlates of alcohol and tobacco use among pregnant women in the United States: evidence from the NSDUH 2005–2014

Alcohol and tobacco use during pregnancy are among the strongest and most preventable risk factors for adverse neonatal health outcomes, but few developmentally sensitive, population-based studies of this phenomenon have been conducted. To address this gap, the present study examined the prevalence and correlates of alcohol and tobacco use among pregnant adolescents (aged 12–17) and adults (aged 18–44) in the United States. Data were derived from the population-based National Survey of Drug Use and Health (80,498 adolescent and 152,043 adult women) between 2005 and 2014. Findings show disconcerting levels of past-month use among pregnant women with 11.5% of adolescent and 8.7% of adult women using alcohol, and 23.0% of adolescent and 14.9% of adult women using tobacco. Compared to their non-pregnant counterparts, pregnant adolescents were less likely to report past 30-day alcohol use (AOR = 0.52, 95% CI = 0.36–0.76), but more likely to report past 30-day tobacco use (AOR = 2.20, 95% CI = 1.53–3.18). Compared to their non-pregnant adult counterparts, pregnant adults were less likely to report using alcohol (AOR = 0.06, 95% CI = 0.05–0.07) and tobacco (AOR = 0.47, 95% CI = 0.43–0.52). Compared to pregnant abstainers, pregnant women reporting alcohol/tobacco use were more likely to have had a major depressive episode in the past 12 months, report criminal justice system involvement, and endorse comorbid alcohol/tobacco use. Given alcohol and tobacco's deleterious consequences during pregnancy, increased attention to reducing use is critical. Findings suggest that tobacco use is especially problematic for both adolescents and adults and is strongly linked with depression and criminal justice involvement, especially among adults

Inhibition of histone acetyltransferase (HAT) activity by HBZ extends beyond the p300/CBP HAT family

We previously reported that HTLV-1 basic leucine zipper factor (HBZ) interacts with the cellular coactivator p300 in cells derived from ATL patients. We further determined that HBZ directly binds to the histone acetyltransferase (HAT) domain of both p300 and its homologue CBP. HAT activity transfers an acetyl group to lysine residues on histone tails and transcription factors to generally upregulate transcription. We observed that the HBZ interaction with the HAT domain of p300/CBP inhibits acetylation of histones and of the tumor suppressor p53. In this study, we wanted to determine whether inhibition of HAT activity was limited to p300/CBP or extended to other HAT families. We focused on the GCN5/ p/CAF and MYST HAT families. We found that HBZ co-immunoprecipitates with both p/CAF and HBO1. These data support a recent finding that HBZ interacts with HBO1 in a yeast two-hybrid assay. Through in vitro HAT assays using recombinant proteins we found that HBZ inhibits acetylation of histone H3 and histone H4 by p/CAF and HBO1, respectively. Furthermore, HBZ reduces acetylation of p53 by p/CAF. Since both p300 and p/CAF acetylate p53 to increase its DNA-binding activity, we performed quantitative RT-PCR to evaluate expression of the p53 target genes, GADD45A and NOXA. We observed reduced mRNA levels of these genes when cells expressed HBZ. Overall these results suggest that HBZ inhibits the HAT activity of coactivators from different HAT families to contribute to transcriptional deregulation

Revised Orbit and Transit Exclusion for HD 114762b

Transiting planets around bright stars have allowed the detailed follow-up and characterization of exoplanets, such as the study of exoplanetary atmospheres. The Transit Ephemeris Refinement and Monitoring Survey (TERMS) is refining the orbits of the known exoplanets to confirm or rule out both transit signatures and the presence of additional companions. Here we present results for the companion orbiting HD 114762 in an eccentric 84 day orbit. Radial velocity analysis performed on 19 years of Lick Observatory data constrain the uncertainty in the predicted time of mid-transit to ~5 hours, which is less than the predicted one-half day transit duration. We find no evidence of additional companions in this system. New photometric observations with one of our Automated Photoelectric Telescopes (APTs) at Fairborn Observatory taken during a revised transit time for companion b, along with 23 years of nightly automated observations, allow us to rule out on-time central transits to a limit of ~0.001 mag. Early or late central transits are ruled out to a limit of ~0.002 mag, and transits with half the duration of a central transit are ruled out to a limit of ~0.003 mag.Comment: 5 pages, 2 figures, accepted for publication in ApJ

An Integrated Analysis of Radial Velocities in Planet Searches

We discuss a Bayesian approach to the analysis of radial velocities in planet searches. We use a combination of exact and approximate analytic and numerical techniques to efficiently evaluate chi-squared for multiple values of orbital parameters, and to carry out the marginalization integrals for a single planet including the possibility of a long term trend. The result is a robust algorithm that is rapid enough for use in real time analysis that outputs constraints on orbital parameters and false alarm probabilities for the planet and long term trend. The constraints on parameters and odds ratio that we derive compare well with previous calculations based on Markov Chain Monte Carlo methods, and we compare our results with other techniques for estimating false alarm probabilities and errors in derived orbital parameters. False alarm probabilities from the Bayesian analysis are systematically higher than frequentist false alarm probabilities, due to the different accounting of the number of trials. We show that upper limits on the velocity amplitude derived for circular orbits are a good estimate of the upper limit on the amplitude of eccentric orbits for eccentricities less than about 0.5.Comment: 16 pages, 9 figures, to appear in MNRA