122 research outputs found
Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles
- Author
- Adamski J. (Jerzy)
- Aulchenko Y.S. (Yurii)
- Axenovich T.I. (Tatiana)
- Biloglav Z. (Zrinka)
- Broer L. (Linda)
- Campbell H. (Harry)
- Campbell S. (Susan)
- Demirkan A. (AyĆe)
- Dharuri H. (Harish)
- Domingues I. (InĂȘs)
- Duijn C.M. (Cornelia) van
- Floyd J. (Jamie)
- Franke L. (Lude)
- Franklin C.S. (Christopher)
- Gieger C. (Christian)
- Gnewuch C. (Carsten)
- Gyllensten U. (Ulf)
- Hastie N. (Nick)
- Hayward C. (Caroline)
- Henneman P. (Peter)
- Hettne K.M. (Kristina)
- Hicks A.A. (Andrew)
- Hoen P.A.C. (Peter) 't
- Hofman A. (Albert)
- Huffman J.E. (Jennifer)
- Igl W. (Wilmar)
- Isaacs A.J. (Aaron)
- Jansen R.C. (Ritsert)
- Janssens A.C.J.W. (CĂ©cile)
- Johansson A. (Ă sa)
- Jonasson I. (Inger)
- Karssen L.C. (Lennart)
- Kirichenko A.V. (Anatoly)
- Klinken J.B. (Jan) van
- Kolcic I. (Ivana)
- Liebisch G. (Gerhard)
- Meitinger T. (Thomas)
- Mook-Kanamori D.O. (Dennis)
- Oostra B.A. (Ben)
- Pattaro C. (Cristian)
- Pfeufer A. (Arne)
- Pichler I. (Irene)
- Polasek O. (Ozren)
- Pramstaller P.P. (Peter Paul)
- Rivadeneira Ramirez F. (Fernando)
- Roos M. (Marco)
- Rudan I. (Igor)
- Schmitz G. (Gerd)
- Struchalin M.V. (Maksim)
- Suhre K. (Karsten)
- Ugocsai P. (Peter)
- Uitterlinden A.G. (André)
- Vitart V. (Veronique)
- Wang-Sattler R. (Rui)
- Wild S.H. (Sarah)
- Willems van Dijk J.A.P. (Ko)
- Wilson J.F. (James F)
- Witteman J.C.M. (Jacqueline)
- Wright A.F. (Alan)
- Zaboli G. (Ghazal)
- Zorkoltseva I.V. (Irina)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 09/12/2013
- Field of study
Background: Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) that associate with clinical phenotypes, but these SNPs usually explain just a small part of the heritability and have relatively modest effect sizes. In contrast, SNPs that associate with metabolite levels generally explain a higher percentage of the genetic variation and demonstrate larger effect sizes. Still, the discovery of SNPs associated with metabolite levels is challenging since testing all metabolites measured in typical metabolomics studies with all SNPs comes with a severe multiple testing penalty. We have developed an automated workflow approach that utilizes prior knowledge of biochemical pathways present in databases like KEGG and BioCyc to generate a smaller SNP set relevant to the metabolite. This paper explores the opportunities and challenges in the analysis of GWAS of metabolomic phenotypes and provides novel insights into the genetic basis of metabolic variation through the re-analysis of published GWAS datasets. Results: Re-analysis of the published GWAS dataset from Illig et al. (Nature Genetics, 2010) using a pathway-based workflow (http://www.myexperiment.org/packs/319.html), confirmed previously identified hits and identified a new locus of human metabolic individuality, associating Aldehyde dehydrogenase family1 L1 (ALDH1L1) with serine/glycine ratios in blood. Replication in an independent GWAS dataset of phospholipids (Demirkan et al., PLoS Genetics, 2012) identified two novel loci supported by additional literature evidence: GPAM (Glycerol-3 phosphate acyltransferase) and CBS (Cystathionine beta-synthase). In addition, the workflow approach provided novel insight into the affected pathways and relevance of some of these gene-metabolite pairs in disease development and progression. Conclusions: We demonstrate the utility of automated exploitation of background knowledge present in pathway databases for the analysis of GWAS datasets of metabolomic phenotypes. We report novel loci and potential biochemical mechanisms that contribute to our understanding of the genetic basis of metabolic variation and its relationship to disease development and progression
Paleogeography and volcanic morphology reconstruction of a buried monogenetic volcanic field (part 2)
- Author
- A Fornaciai
- AD Miall
- Alan Bischoff
- Alan Patrick Bischoff
- Andrea Barrier
- Andrew Nicol
- B Zimanowski
- BD Field
- Bernd Zimanowski
- C.K. Morley
- CAL Jackson
- Charlotte E. McLean
- Christian Timm
- Craig Magee
- D Hunt
- D. S. Coombs
- David A. Clague
- DM Hansen
- DP Strogen
- Floyd J. Fowler
- Gbor Kereszturi
- Geoffrey E. Batt
- H Lu
- H Lu
- Hanfei Wang
- HH Svensen
- I Aarnes
- IC Wright
- J.D.L. White
- James D.L. White
- James D.L. White
- James D.L. White
- JDL White
- JDL White
- JI Raine
- JR Carlson
- JW Head
- K NĂ©meth
- K NĂ©meth
- L Agirrezabala
- L Oliveira
- Lennon Infante-Paez
- M Rohrman
- MG Laird
- MM Abdelmalak
- N Mortimer
- ND Deardorff
- Nick Schofield
- O Catuneanu
- P Reynolds
- P. Reynolds
- PF Ballance
- PJJ Kamp
- R Alvarenga
- R. J. Sewell
- RA Cas
- RAF Cas
- RAF Cas
- Raymond A.F. Cas
- RH Herzer
- RM Mitchum
- S Planke
- S Planke
- S. PLANKE
- Sabine Klarner
- Shan de Silva
- Simon P. Holford
- SP Holford
- SR Schutter
- SS Angkasa
- Sverre Planke
- V Lorenz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Fourth Report on Chicken Genes and Chromosomes 2022
- Author
- Alfieri James M.
- Anthony Nick
- Arensburger Peter
- Athrey Giridhar N.
- Balacco Jennifer
- Balic Adam
- Bardou Philippe
- Barela Paul
- Bigot Yves
- Blackmon Heath
- Borodin Pavel M.
- Carroll Rachel
- Casono Meya C.
- Charles Mathieu
- Cheng Hans
- Chiodi Maddie
- Cigan Lacey
- Coghill Lyndon M.
- Crooijmans Richard
- Das Neelabja
- Davey Sean
- Davidian Asya
- Degalez Fabien
- Dekkers Jack M.
- Derks Martijn
- Diack Abigail B.
- Djikeng Appolinaire
- Drechsler Yvonne
- Dyomin Alexander
- Fedrigo Olivier
- Fiddaman Steven R.
- Formenti Giulio
- Frantz Laurent A.F.
- Fulton Janet E.
- Gaginskaya Elena
- Galkina Svetlana
- Gallardo Rodrigo A.
- Geibel Johannes
- Gheyas Almas
- Godinez Cyrill John P.
- Goodell Ashton
- Graves Jennifer A. M.
- Griffin Daren K.
- Haase Bettina
- Han Jian-Lin
- Hanotte Olivier
- Henderson Lindsay J.
- Hou Zhuo-Cheng
- Howe Kerstin
- Huynh Lan
- Ilatsia Evans
- Jarvis Erich
- Johnson Sarah M.
- Kaufman Jim
- Kelly Terra
- Kemp Steve
- Kern Colin
- Keroack Jacob H.
- Klopp Christophe
- Lagarrigue Sandrine
- Lamont Susan J.
- Lange Margaret
- Lanke Anika
- Larkin Denis M.
- Larson Greger
- Layos John King N.
- Lebrasseur Ophélie
- Malinovskaya Lyubov P.
- Martin Cerezo Maria Luisa
- Martin Rebecca J.
- Mason Andrew S.
- McCarthy Fiona M.
- McGrew Michael J.
- Mountcastle Jacquelyn
- Muhonja Christine Kamidi
- Muir William
- Muret KĂ©vin
- Murphy Terence
- Ngâangâa Ismael
- Nishibori Masahide
- Ogugo Moses
- Okimoto Ron
- Ouko Ochieng
- OâConnor Rebecca E.
- Patel Hardip R.
- Perini Francesco
- Pigozzi MarĂa Ines
- Potter Krista C.
- Price Peter D.
- Reimer Christian
- Rice Edward S.
- Rocos Nicolas
- Rogers Thea F.
- Saelao Perot
- Schauer Jens
- Schnabel Robert
- Schneider Valerie
- Simianer Henner
- Smith Adrian
- Smith Jacqueline
- Stevens Mark P.
- Stiers Kyle
- Tiambo Christian Keambou
- Tixier-Boichard Michele
- Torgasheva Anna A.
- Tracey Alan
- Tregaskes Clive A.
- Vervelde Lonneke
- Wang Ying
- Warren Wesley C.
- Waters Paul D.
- Webb David
- Weigend Steffen
- Wolc Anna
- Wright Alison E.
- Wright Dominic
- Wu Zhou
- Yamagata Masahito
- Yang Chentao
- Yin Zhong-Tao
- Young Michelle C.
- Zhang Guojie
- Zhao Bingru
- Zhou Huaijun
- Publication venue
- 'S. Karger AG'
- Publication date
- 30/01/2023
- Field of study
International audienc
Fourth Report on Chicken Genes and Chromosomes 2022
- Author
- Alfieri James M.
- Anthony Nck
- Arensburger Peter
- Athrey Giridhar N.
- Balacco Jennifer
- Balic Adam
- Bardou Philippe
- Barela Paul
- Bigot Yves
- Bingru Zhao
- Blackmon Heath
- Borodin Pavel M.
- Carroll Rachel
- Casono Meya C.
- Charles Mathieu
- Cheng Hans
- Chentao Yang
- Chiodi Maddie
- Cigan Lacey
- Coghill Lyndon M.
- Crooijmans Richard
- Das Neelabja
- Davey Sean
- Davidian Asya
- Degalez Fabien
- Dekkers Jack M.
- Derks Martijn
- Diack Abigail B.
- Djikeng Appolinaire
- Drechsler Yvonne Drechsler
- Dyomin Alexander
- Fedrigo Olivier
- Fiddaman Steven R.
- Formenti Giulio
- Frantz , Laurent A.F.
- Fulton Janet E.
- Gaginskaya Elena
- Galkina Svetlana
- Gallardo Rodrigo A.
- Geibel Johannes
- Gheyas Almas
- Godinez Cyrill John P.
- Goodell Ashton
- Graves Jennifer A.M.
- Griffin Darren K.
- Guojie Zhang
- Haase Bettina
- Han Jianlin
- Hanotte Olivier H.
- Henderson Lindsay J.
- Howe Kerstin Howe
- Huaijun Zhou
- Ilatsia Evans
- Jarvis Erich
- Johnson Sarah M.
- Kaufman Jim
- Kelly Terra
- Kemp Stephen J.
- Kern Colin
- Keroack Jacob H.
- Klopp Christophe
- Lagarrigue Sandrine
- Lamont Susan J.
- Lan Huynh
- Lange Margaret
- Lanke Anika
- Larkin Denis M.
- Larson Greger
- Layos John King N.
- Lebrasseur Ophélie
- Malinovskaya Lyubov P.
- Martin Cerezo Maria Luisa
- Martin Rebecca J.
- Mason Andrew S.
- McCarthy Fiona M.
- McGrew Michael J.
- Mountcastle Jacquelyn
- Muhonja Christine Kamidi
- Muir William
- Muret KĂ©vin
- Murphy Terence
- Ng'ang'a Ismael
- Nishibori Masahide
- O'Connor Rebecca E.
- Ogugo Moses
- Okimoto Ron
- Ouko Ochieng
- Patel Hardip R. Patel
- Perini Francesco
- Pigozzi MarĂa InĂ©s
- Potter Krista C.
- Price Peter D.
- Reimer Christian
- Rice Edward S.
- Rocos Nicolas
- Rogers Thea F.
- Saelao Perot
- Schauer Jens
- Schnabel Robert
- Schneider Valerie
- Simianer Henner
- Smith Adrian
- Stevens Mark P.
- Stiers Kyle
- Tiambo Christian Keambou
- Tixier-Boichard Michele
- Torgasheva Anna A.
- Tracey Alan
- Tregaskes Clive A.
- Vervelde Lonneke
- Warren Wesley C.
- Waters Paul D. Waters
- Webb David
- Weigend Steffen
- Wolc Anna
- Wright Alison E.
- Wright Dominic
- Yamagata Masahito
- Ying Wang
- Young Michelle C.
- Zhong-Tao Yin
- Zhou Wu
- Zhuo-Cheng Hou
- Publication venue
- 'S. Karger AG'
- Publication date
- 31/01/2023
- Field of study
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Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (Nature Communications, (2021), 12, 1, (24), 10.1038/s41467-020-19366-9)
- Author
- Abecasis G.R. (Goncalo R.)
- Altshuler D. (David)
- Amin N. (Najaf)
- Amin N. (Najaf)
- An P. (Ping)
- Bakker S.J.L. (Stephan)
- Balkau B. (Beverley)
- Bandinelli S. (Stefania)
- Barroso I.E. (InĂȘs)
- Bennett A.J. (Amanda J.)
- Bergman R.N. (Richard N.)
- Bielak L.F. (Lawrence F.)
- BlĂŒher M. (Matthias)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boerwinkle E.A. (Eric)
- Boettcher Y. (Yvonne)
- Bonnefond A. (Amélie)
- Boomsma D.I. (Dorret I.)
- Bornstein S.R. (Stefan)
- Bouatia-Naji N. (Nabila)
- Campbell H. (Harry)
- Campbell S. (Susan)
- Carlson O.D. (Olga)
- Dedoussis G.V. (George)
- Deloukas P. (Panos)
- Dimas A.S. (Antigone)
- Dimitriou M. (Maria)
- Doney A.S.F. (Alex)
- Duijn C.M. (Cornelia) van
- Egan J. (Josephine)
- Eriksson P. (Per)
- Esko T. (TÔnu)
- Fadista J. (JoĂŁo)
- Faggian A. (Alessia)
- Faire U.D. (Ulf)
- Fall T. (Tove)
- Ferrucci L. (Luigi)
- Ford I. (Ian)
- Forouhi N.G. (Nita)
- Franco-Cereceda A. (Anders)
- Franks P.W. (Paul W.)
- Frants R.R. (Rune)
- Fraser R.M. (Ross)
- Frayling T.M. (Timothy M.)
- Froguel P. (Philippe)
- Ganna A. (Andrea)
- Geus E.J.C. (Eco) de
- Giedraitis V. (Vilmantas)
- Gieger C. (Christian)
- Goel A. (Anuj)
- Grallert H. (Harald)
- Groop L. (Leif)
- Groves C.J. (Christopher J.)
- Gudnason V. (Vilmundur)
- GĂ„din J.R. (Jesper R.)
- Hamsten A. (Anders)
- Harris T.B. (Tamara)
- Harst P. (Pim van der)
- Hastie N. (Nick)
- Hayward C. (Caroline)
- Herder C. (Christian)
- Hicks A.A. (Andrew A.)
- Hingorani A. (Aroon)
- Hofman A. (Albert)
- Horikoshi M. (Momoko)
- Hottenga J.J. (Jouke Jan)
- Hovingh G.K. (G. Kees)
- Illig T. (Thomas)
- Ingelsson E. (Erik)
- Iperen E. (Erik van)
- Isaacs A.J. (Aaron)
- Jackson A.U. (Anne U.)
- Jansen R. (Rick)
- Jarvelin M.-R. (Marjo-Riitta)
- Jiang L. (Longda)
- Johnson P.C.D. (Paul C. D.)
- Johnson T. (Toby)
- Jukema J.W. (Jan Wouter)
- Kaakinen M.A. (Marika A.)
- Kanoni S. (Stavroula)
- Kao W.H.L. (Wen)
- Kaprio J. (Jaakko)
- Kapur K. (Karen)
- Kardia S.L.R. (Sharon L. R.)
- Karpe F. (Fredrik)
- Keinanen-Kiukaanniemi S. (Sirkka)
- KieĂ W. (Wieland)
- Kinnunen L. (Leena)
- Kivimaki M. (Mika)
- Kleber M.E. (Marcus E.)
- Koistinen H.A. (Heikki A.)
- Kovacs P. (Peter)
- Krus U. (Ulrika)
- Kumari M. (Meena)
- Kuusisto J. (Johanna)
- Körner A. (Antje)
- Laakso M. (Markku)
- Lagou V. (Vasiliki)
- Lakka T.A. (Timo)
- Langenberg C. (Claudia)
- Lecoeur C. (CĂ©cile)
- Li G. (Guo)
- Lindgren C.M. (Cecilia M.)
- Lindström J. (Jaana)
- Liu Y. (Yongmei)
- Loos R.J.F. (Ruth J. F.)
- Luan J. (Jianâan)
- Lyssenko V. (Valeriya)
- Magnusson P.K. (Patrik)
- Mahajan A. (Anubha)
- Marullo L. (Letizia)
- Matullo G.
- McCarthy M.I. (Mark I.)
- McLachlan S. (Stela)
- Meigs J.B. (James B.)
- Meitinger T. (Thomas)
- Meneton P. (Pierre)
- Metspalu A. (Andres)
- Meyer J. (Julia)
- Mihailov E. (Evelin)
- Miljkovic I. (Iva)
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- Navarro P. (Pau)
- Nicholson G. (George)
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- Palmer C.N.A. (Colin)
- Palmer L.J. (Lyle J.)
- Pedersen N.L. (Nancy)
- Penninx B.W.J.H. (Brenda)
- Perola M. (Markus)
- Perry J.R.B. (John R. B.)
- Peyser P.A. (Patricia A.)
- Polasek O. (Ozren)
- Pourcain B.S. (Beate St)
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- Pramstaller P.P. (Peter Paul)
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- Prokopenko I. (Inga)
- Province M.A. (Michael A.)
- Rasmussen-Torvik L.J. (Laura)
- Rauramaa R. (Rainer)
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- Rudan I. (Igor)
- Rybin D. (Denis)
- Saaristo T. (Timo)
- Salo P. (Perttu)
- Salomaa V. (Veikko)
- Sanna S. (Serena)
- Sarin A.-P.
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- Scapoli C. (Chiara)
- Schwarz P.E.H. (Peter)
- Shin S.-Y.
- Shuldiner A.R. (Alan R.)
- Shungin D. (Dmitry)
- Sijbrands E.J.G. (Eric)
- Silbernagel G. (GĂŒnther)
- Siscovick D.S. (David)
- Smith A.V. (Albert)
- Smith G.D. (George Davey)
- Snieder H. (Harold)
- Soranzo N. (Nicole)
- Stafford M.
- Stathopoulou M.G. (Maria G)
- Strawbridge R.J. (Rona)
- Stumvoll M. (Michael)
- Tanaka T. (Toshiko)
- Thorand B. (Barbara)
- Thorleifsson G. (Gudmar)
- Timpson N.J. (Nicholas J.)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Tönjes A. (Anke)
- Ulrich A. (Anna)
- Uusitupa M. (Matti)
- Verweij N. (Niek)
- Visvikis-Siest S. (Sophie)
- Vitart V. (Veronique)
- Vollenweider P. (Peter)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard)
- Watkins H. (Hugh)
- Webster R.J. (Rebecca J.)
- Wild S.H. (Sarah)
- Willems S.M. (Sara)
- Willemsen G. (Gonneke)
- Wilson J.F. (James F.)
- Winkelmann B.
- Wolffenbuttel B.H.R. (Bruce)
- Wright A.F. (Alan F.)
- Yengo L. (Loic)
- Zemunik T. (Tatijana)
- Zudina L. (Liudmila)
- Zwart J-A. (John-Anker)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/02/2021
- Field of study
The original version of this Article contained an error in Fig. 2, in which panels a and b were inadvertently swapped. This has now been corrected in the PDF and HTML versions of the Article
Erratum to: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
- Author
- Abecasis G. (Gonçalo)
- Almgren P. (Peter)
- Amin N. (Najaf)
- Amouyel P. (Philippe)
- Arking D.E. (Dan)
- Attia J. (John)
- Ayers K.L. (Kristin)
- Barbieri C.M. (Caterina M.)
- Barnes M.J. (Michael)
- Batini C. (Chiara)
- Bis J.C. (Joshua)
- Blake T. (Tineka)
- Bochud M. (Murielle)
- Boehnke M. (Michael)
- Boerwinkle E. (Eric)
- Boomsma D.I. (Dorret I.)
- Bottinger E.P. (Erwin P.)
- Boutin T. (Thibaud)
- Braund P.S. (Peter)
- Brown M.J. (Morris)
- Brumat M. (Marco)
- Butterworth A.S. (Adam S.)
- Cabrera C.P. (Claudia P.)
- Campbell A. (Archie)
- Campbell H. (Harry)
- Caulfield M. (Mark)
- Chakravarti A. (Aravinda)
- Chambers J.C. (John C.)
- Chasman D.I. (Daniel)
- Chauhan G. (Ganesh)
- Cho K. (Kelly)
- Ciullo M. (Marina)
- Cocca M. (Massimiliano)
- Collins F. (Francis)
- Conen D. (David)
- Connell J. (John)
- Cordell H.J. (Heather)
- Cucca F. (Francesco)
- Danesh J. (John)
- Davies G. (Gail)
- de Borst M.H. (Martin H.)
- Deary I.J. (Ian)
- Debette S. (Stéphanie)
- Deelen J. (Joris)
- Del Greco M F. (Fabiola)
- Demirkale C.Y. (Cumhur Yusuf)
- Dimou N. (Niki)
- Ding J. (Jun)
- Doney A.S.F. (Alex)
- Duijn C.M. (Cornelia) van
- Dörr M. (Marcus)
- Edwards T.L. (Todd L.)
- Ehret G.B. (Georg B.)
- Elliott P. (Paul)
- Elosua R. (Roberto)
- Enroth S. (Stefan)
- Erzurumluoglu A.M. (A. Mesut)
- Esko T. (Tonu)
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 14/11/2018
- Field of study
In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML.
The error has now been corrected in the HTML version of the paper
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
- Author
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- Abecasis G.R. (Gonçalo)
- Abecasis G.R. (Gonçalo)
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- Absher D. (Devin)
- Absher D. (Devin)
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- Narisu N. (Narisu)
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- Quertermous T. (Thomas)
- Quyyumi A.A. (Arshed)
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- Ripatti S. (Samuli)
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- Shi J. (Jianxin)
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- Sun Q. (Qi)
- Surdulescu G. (Gabriela)
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- Tammesoo M.L.
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- Thorgeirsson G. (Gudmundur)
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- van't Hooft F. (Ferdinand)
- Van't Hooft F. (Ferdinand)
- Vatin V. (Vincent)
- Vedantam S. (Sailaja)
- Visscher P.M. (Peter M.)
- Visscher P.M. (Peter)
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- Vliet-Ostaptchouk J.V. (Jana) van
- Voight B.F. (Benjamin)
- Wabitsch M. (Martin)
- Waeber G. (GĂ©rard)
- Waite L. (Lindsay)
- Walker M. (Mark)
- Wallaschofski H. (Henri)
- Walters G.B. (Bragi)
- Wareham N.J. (Nicholas J.)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R. (Ryan)
- Welch R.P. (Ryan)
- Wells G.A. (George)
- Weyant R.J. (Robert)
- Wheeler E. (Eleanor)
- White C.C. (Charles)
- Wichmann H.-E. (H-Erich)
- Wichmann H.E. (Heinz Erich)
- Widen E. (Elisabeth)
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- Wijmenga C. (Cisca)
- Wiklund F. (Fredrik)
- Wild P.S. (Philipp)
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- Wilk A. (Alicja)
- Willemsen G.A.H.M. (Gonneke)
- Willenborg C. (Christina)
- Willer C.J. (Cristen)
- Wilson J.F. (James F.)
- Wingerden S. (Sophie) van
- Winkler T.W. (Thomas W.)
- Witte D.R. (Daniel R.)
- Witte D.R. (Deniel)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C.M.)
- Wood A.R. (Andrew)
- Workalemahu T. (Tsegaselassie)
- Wright A.F. (Alan)
- Wright B.J. (Benjamin)
- Wu G. (Guanming)
- Xie W. (Weijia)
- Xu J. (Jianfeng)
- Yang J. (Jian)
- Yang J. (Joanna)
- Yang T.-P. (Tsun-Po)
- Ye S. (Shu)
- Zabena C. (Carina)
- Zaidi M.A. (Aghar)
- Zaman K.S. (Khan Shah)
- Zeggini E. (Eleftheria)
- Zeller T. (Tanja)
- Zethelius B. (Björn)
- Zgaga L. (Lina)
- Zhang Q. (Qunyuan)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zitting P. (Paavo)
- Zondervan K.T. (Krina T.)
- Zondervan K.T. (Krina)
- Zwart J-A. (John-Anker)
- Ăhrvik J. (John)
- Ăstenson C.-G. (Claes-Göran)
- Publication venue
- Publication date
- 01/10/2011
- Field of study
OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 Ă 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 Ă 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 Ă 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals
- Author
- Abecasis G.R. (Goncalo R.)
- Abecasis G.R. (Goncalo R.)
- Abecasis G.R. (Gonçalo R.)
- Abecasis G.R. (Gonçalo)
- Adair L.S. (Linda)
- Allison M.A. (Matthew)
- Altshuler D. (David)
- Altshuler D. (David)
- Amin N. (Najaf)
- An P. (Ping)
- Ardlie K.G. (Kristin)
- Ardlie K.G. (Kristin)
- Ariyurek Y. (Yavuz)
- Aulchenko Y.S. (Yurii S.)
- Aulchenko Y.S. (Yurii S.)
- Aulchenko Y.S. (Yurii)
- Bacquer O.L. (Olivier)
- Balkau B. (Beverley)
- Balkau B. (Beverley)
- Ballantyne C. (Christie)
- Ballantyne C.M. (Christie M.)
- Ballantyne C.M. (Christie M.)
- Bandinelli S. (Stefania)
- Bandinelli S. (Stefania)
- Barbalic M. (maja)
- Barroso I.
- Barroso I.E. (InĂȘs)
- Barroso I.E. (InĂȘs)
- Barter P. (Phil)
- Beekman M. (Marian)
- Beilby J.P. (John)
- Ben-Shlomo Y.
- Benediktsson R. (Rafn)
- Benediktsson R. (Rafn)
- Bennett A.J. (Amanda)
- Bennett A.J. (Amanda)
- Bergman R.N. (Richard N.)
- Bergman R.N. (Richard N.)
- Bergman R.N. (Richard N.)
- Bergmann S.M. (Sven)
- Bidulescu A. (Aurelian)
- Bis J.C. (Joshua)
- Blagieva R. (Roza)
- Bochud M. (Murielle)
- Boehm B.O. (Bernhard)
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- Boehnke M. (Michael)
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- Boerwinkle E. (Eric)
- Boerwinkle E. (Eric)
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- Bonnycastle L.L. (Lori L.)
- Bonnycastle L.L. (Lori L.)
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- Boström K.B. (Kristina Bengtsson)
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- Bumpstead S. (Suzannah)
- Burtt N.P. (Noël P.)
- Burtt N.P. (Noël)
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- Campbell H. (Harry)
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- Caulfield M.J. (Mark J.)
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- Chen Y.-D.I. (Yii-Der Ida)
- Chen Y.D.I. (Yii-Der Ida)
- Chines P.S. (Peter S.)
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- Cho Y.S. (Yoon Shin)
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- Coassin S. (Stefan)
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- Collins F.S. (Francis S.)
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- Crawford G. (Gabe)
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- Dehghan A. (Abbas)
- Deloukas P. (Panagiotis)
- Deloukas P. (Panagiotis)
- Delplanque J. (Jerome)
- DIAGRAM+ Consortium
- Dina C. (Christian)
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- Gieger C. (Christian)
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- Glazer N.L. (Nicole)
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- Gloyn A.L. (Anna L.)
- Gloyn A.L. (Anna)
- Go M.J. (Min Jin)
- Goel A. (Anuj)
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- Goodarzi M. (Mark)
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- Johnson P.R.V. (Paul R. V.)
- Johnson P.R.V. (Paul)
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- Kesaniemi Y.A. (Antero)
- Khaw K.-T. (Kay-Tee)
- Khaw K.T.
- Kim Y-J. (Yong-Jin)
- Kim Y.J.
- Kivimaki M. (Mika)
- Kizer J.R. (Jorge)
- Klopp N. (Norman)
- Klopp N. (Norman)
- Kloppenburg M. (Margreet)
- Knight B. (Beatrice)
- Kong A. (Augustine)
- Kong A. (Augustine)
- Kooner J. (Jaspal)
- Koseki M. (Masahiro)
- Koskinen S. (Seppo)
- Kovacs P. (Peter)
- Kraft P. (Peter)
- Kristiansson K. (Kati)
- Kronenberg F. (Florian)
- Kronenberg F. (Florian)
- Kumari M. (Meena)
- Kuusisto J. (Johanna)
- Kuzawa C.W. (Christopher W.)
- Kuzawa C.W. (Christopher)
- Kyvik K.O. (Kirsten O.)
- Kyvik K.O. (Kirsten Ohm)
- KÀhönen M. (Mika)
- König I.R. (Inke)
- Laakso M. (Markku)
- Laakso M. (Markku)
- Laakso M. (Markku)
- Laaksonen R. (Reijo)
- Ladouceur M. (Martin)
- Lajunen T. (Taina)
- Lakatta E.G. (Edward G.)
- Lamina C. (Claudia)
- Lamina C. (Claudia)
- Lange L.A. (Leslie)
- Lange L.A. (Leslie)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Langenberg C. (Claudia)
- Lathrop G. (GMark)
- Launer L.J. (Lenore J.)
- Lauritzen T. (Torsten)
- Lawlor D.A. (Debbie)
- Lecoeur C. (CĂ©cile)
- Lee J.-Y. (Jong-Young)
- LehtimÀki T. (Terho)
- Lettre G. (Guillaume)
- Li M. (Man)
- Li M. (Man)
- Li X. (Xiaohui)
- Li X. (Xiaohui)
- Li Y. (Yun)
- Lieverse A.G. (Aloysius)
- Lindgren C.M. (Cecilia M.)
- Lindgren C.M. (Cecilia)
- Liu C.-T. (Ching-Ti)
- Liu Y. (YongMei)
- Lohman K. (Kurt)
- Lokki M.L.
- Loo B.-M. (Britt-Marie)
- Loos R.J.F. (Ruth)
- Loos R.J.F. (Ruth)
- Loos R.J.F. (Ruth)
- Luan J. (Jianâan)
- Luan J. (Jianâan)
- Luben R.N. (Robert)
- Lucas G. (Gavin)
- Lyssenko V. (Valeriya)
- Lyssenko V. (Valeriya)
- LyytikÀinen L.-P. (Leo-Pekka)
- MAGIC Consortium
- Magnusson P.K. (Patrik)
- Magnusson P.K.E. (Patrik K. E.)
- Mahley R. (Robert)
- Mangino M. (Massimo)
- Mangino M. (Massimo)
- Manning A.K. (Alisa K.)
- Manning A.K. (Alisa)
- Marmot M. (Michael)
- Marre M. (Michel)
- Marroni F. (Fabio)
- Martin N.G. (Nicholas)
- Martinez-Larrad M.T. (Maria Teresa)
- Masson D. (David)
- McArdle W.L. (Wendy)
- McAteer J.B. (Jarred)
- McCarroll S.A. (Steve)
- McCarroll S.A. (Steven)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark I.)
- McCarthy M.I. (Mark)
- McCulloch L.J. (Laura J.)
- McCulloch L.J. (Laura)
- McPherson R. (Ruth)
- Meigs J.B. (James B.)
- Meigs J.B. (James)
- Meigs J.B. (James)
- Meisinger C. (Christa)
- Meitinger T. (Thomas)
- Meitinger T. (Thomas)
- Meitinger T. (Thomas)
- Melander O. (Olle)
- Melzer D. (David)
- Meneton P. (Pierre)
- Meulenbelt I. (Ingrid)
- Meyre D. (David)
- Midthjell K. (Kristian)
- Mitchell B.D. (Braxton)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen L.)
- Mohlke K.L. (Karen)
- Mooser V. (Vincent)
- Mooser V. (Vincent)
- Mooser V.E. (Vincent E.)
- Morken M.A. (Mario A.)
- Morken M.A. (Mario)
- Morris A.D. (Andrew D.)
- Morris A.D. (Andrew)
- Morris A.P. (Andrew P.)
- Morris A.P. (Andrew P.)
- Morris A.P. (Andrew)
- Mukherjee S. (Sutapa)
- Munroe P. (Patricia)
- Musani S. (Solomon)
- Musunuru K. (Kiran)
- MuTHER Consortium
- MĂ€gi R. (Reedik)
- Naitza S. (Silvia)
- Narisu N. (Narisu)
- Narisu N. (Narisu)
- Nathan D.M. (David)
- Navarro P. (Pau)
- Navarro P. (Pau)
- Neville M.J. (Matthew)
- Nickerson D.A. (Deborah A.)
- Nickerson D.A. (Deborah)
- Nieminen M.S. (Markku)
- Nilsson P. (Peter)
- Nuotio M.-L. (Marja-Liisa)
- Oostra B.A. (Ben A.)
- Oostra B.A. (Ben)
- Oostra B.A. (Ben)
- Ordovas J.M. (Jose M.)
- Ordovas J.M. (Jose)
- Orho-Melander M. (Marju)
- OrrĂč M. (Marco)
- Owen K.R. (Katharine)
- OâConnell J. (Jeffrey)
- Pakyz R. (Ruth)
- Palmer C. (Cameron)
- Palmer C.N.A. (Colin N. A.)
- Palmer C.N.A. (Colin)
- Pankow J.S. (James S.)
- Pankow J.S. (James)
- Paolisso G. (Giuseppe)
- Pare G. (Guillame)
- Park T. (Taesung)
- Parker A.N. (Alex)
- Pattaro C. (Cristian)
- Pattaro C. (Cristian)
- Pattou F. (François)
- Paulweber B. (Bernhard)
- Payne F. (Felicity)
- Payne F. (Felicity)
- Pearson D. (Daniel)
- Peden J. (John)
- Pedersen N.L. (Nancy)
- Pedersen O. (Oluf)
- Pedersen O. (Oluf)
- Peloso G.M. (Gina)
- Peltonen L. (Leena Johanna)
- Penninx B.W.J.H.
- Penninx B.W.J.H. (Brenda W. J. H.)
- Penninx B.W.J.H. (Brenda)
- Perola M. (Markus)
- Perola M. (Markus)
- Perola M. (Markus)
- Perry J.R.B. (John R. B.)
- Perry J.R.B. (John R. B.)
- Perry J.R.B. (John)
- Petersen A.K.
- Pfeiffer A.F.H. (Andreas)
- Pichler I. (Irene)
- Pichler I. (Irene)
- Platou C.P. (Carl)
- Polasek O. (Ozren)
- Posthuma D. (Danielle)
- Potter S.C. (Simon)
- Pouta A. (Anneli)
- Pramstaller P.P. (Peter P.)
- Pramstaller P.P. (Peter P.)
- Pramstaller P.P. (Peter Paul)
- Pramstaller P.P. (Peter Paul)
- Proença C. (Christine)
- Prokopenko I. (Inga)
- Prokopenko I. (Inga)
- Province M.A. (Mike)
- Psaty B.M. (Bruce M.)
- Psaty B.M. (Bruce)
- Qi L. (Lu)
- Qi L. (Lu)
- Quertermous T. (Thomas)
- Quertermous T. (Thomas)
- Rader D.J. (Daniel)
- Raitakari O. (Olli)
- Randall J.C. (Joshua)
- Rasmussen-Torvik L.J. (Laura)
- Rathmann W. (Wolfgang)
- Rathmann W. (Wolfgang)
- Raychaudhuri S. (Soumya)
- Rayner N.W. (Nigel W.)
- Rayner N.W. (Nigel William)
- Redline S. (Susan)
- Reilly M.P. (Muredach P.)
- Rice K.M. (Kenneth)
- Richards J.B. (J. Brent)
- Ricketts S.L. (Sally)
- Ridker P.M. (Paul)
- Rieder M. (Mark)
- Rieder M. (Mark)
- Ripatti S. (Samuli)
- Ripatti S. (Samuli)
- Rivadeneira Ramirez F. (Fernando)
- Roberts R. (Robert)
- Robertson N.R. (Neil)
- Roccasecca R.M.
- Rocheleau G. (Ghislain)
- Rocheleau G. (Ghislain)
- Roden M. (Michael)
- Roden M. (Michael)
- Rolandsson O. (Olov)
- Rose L.M. (Lynda)
- Rotter J.I. (Jerome I)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Rudan I. (Igor)
- Ruokonen A. (Aimo)
- Ruokonen A. (Aimo)
- Rybin D. (Denis)
- Sabatti C. (Chiara)
- Saharinen J. (Juha)
- Salomaa V. (Veikko)
- Salomaa V. (Veikko)
- Salomaa V. (Veikko)
- Samani N.J. (Nilesh)
- Samani N.J. (Nilesh)
- Sampson M.J. (Michael J)
- Sampson M.J. (Michael)
- Sandbaek A. (Annelli)
- Sandhu M. (Manjinder)
- Sandhu M.S. (Manjinder)
- Sanna S. (Serena)
- Sanna S. (Serena)
- Sattar N. (Naveed)
- Saxena R. (Richa)
- Saxena R. (Richa)
- Sayer A.A.
- Schadt E.E. (Eric E.)
- Schadt E.E. (Eric)
- Scheet P. (Paul)
- Schlessinger D. (David)
- Schlessinger D. (David)
- Schunkert H. (Heribert)
- Schwarz P.E.H. (Peter)
- Scott L.J. (Laura J.)
- Scott L.J. (Laura)
- Scott R.A. (Robert)
- Scuteri A. (Angelo)
- Scuteri A. (Angelo)
- Scuteri A. (Angelo)
- Seedorf U. (Udo)
- SegrĂš A.V. (Ayellet)
- Seielstad M. (Mark)
- Semple R.K. (Robert K.)
- Serrano-RĂos M. (Manuel)
- Sethupathy P. (Praveen)
- Sharp S.J. (Stephen)
- Shields B.M. (Beverley)
- Shields B.M. (Beverley)
- Shrader P. (Peter)
- Shrader P. (Peter)
- Shuldiner A.R. (Alan)
- Sigurdsson G. (Gunnar)
- Sigursson G. (Gunnar)
- Sijbrands E. (Eric)
- Sijbrands E.J.G. (Eric J. G.)
- Sijbrands E.J.G. (Eric)
- Silander K. (Kaisa)
- Silander K. (Kaisa)
- Silveira A. (Angela)
- Sim X. (Xueling)
- Sim X. (Xueling)
- Simpson L. (Laila)
- Singleton A. (Andrew)
- Sinisalo J. (Juha)
- Siscovick D.S. (David)
- Siscovick D.S. (David)
- Sladek R. (Rob)
- Sladek R. (Rob)
- Slagboom P.E. (Eline)
- Small K.S. (Kerrin)
- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith A.V. (Davey)
- Smith G.D. (George Davey)
- Smith J.D. (Joshua D.)
- Smith N.L. (Nicholas)
- Song K. (Kijoung)
- Soranzo N. (Nicole)
- Soranzo N. (Nicole)
- Sovio U. (Ulla)
- SparsĂž T. (Thomas)
- SparsĂž T. (Thomas)
- Spector T.D. (Tim D.)
- Spector T.D. (Timothy D.)
- Spector T.D. (Timothy)
- Spranger J. (Joachim)
- St Pourcain B. (Beate)
- Stefansson K. (Kari)
- Stefansson K. (Kari)
- Stein L.D. (Lincoln)
- Steinthorsdottir V. (Valgerdur)
- Steinthorsdottir V. (Valgerdur)
- Strachan D.P. (David)
- Strassburger K. (Klaus)
- Stringham H.M. (Heather M.)
- Stringham H.M. (Heather M.)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Stylianou I.M. (Ioannis M.)
- Stylianou I.M. (Ioannis)
- Sun Q. (Qi)
- Surakka I. (Ida)
- Swift A.J. (Amy)
- Swift A.J. (Amy)
- Syddall H. (Holly)
- SyvÀnen A.C.
- Tai E.-S. (E-Shyong)
- Tai E.S. (Shyong)
- Tall A.R. (Alan R.)
- Tanaka T. (Toshiko)
- Taylor H.A. (Herman A.)
- Taylor H.A. (Herman)
- Teslovich T.M. (Tanya M.)
- Teslovich T.M. (Tanya M.)
- Thompson J.R. (John)
- Thompson J.R. (John)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorleifsson G. (Gudmar)
- Thorleifsson G. (Gudmar)
- Thorleifsson G. (Gudmar)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Thorsteinsdottir U. (Unnur)
- Tichet J. (Jean)
- Tichet J. (Jean)
- Timpson N.J. (Nicholas J.)
- Timpson N.J. (Nicholas)
- Tracy R.P. (Russell)
- Tuomi T. (Tiinamaija)
- Tuomi T. (Tiinamaija)
- Tuomilehto J. (Jaakko)
- Tuomilehto J. (Jaakko)
- Tuomilehto J. (Jaakko)
- Tönjes A. (Anke)
- Uda M. (Manuela)
- Uda M. (Manuela)
- Uh H.-W. (Hae-Won)
- Uitterlinden A. (Andre)
- Uitterlinden A.G. (Andre G.)
- Uitterlinden A.G. (André)
- Valle T.T. (Timo T.)
- van Duijn C. (Cornelia)
- van Duijn C.M. (Cornelia M.)
- van Duijn C.M. (Cornelia M.)
- van Hoek M. (Mandy)
- Varma D. (Dhiraj)
- Viikari J. (Jorma)
- Visvikis-Siest S. (Sophie)
- Vitart V. (Veronique)
- Vitart V. (Veronique)
- Vliet-Ostaptchouk J.V. (Jana) van
- Vogelzangs N. (Nicole)
- Voight B.F. (Benjamin F.)
- Voight B.F. (Benjamin F.)
- Voight B.F. (Benjamin)
- Vollenweider P. (Peter)
- Vollenweider P. (Peter)
- Vollenweider P. (Peter)
- Waeber G. (GĂ©rard)
- Waeber G. (GĂ©rard)
- Wagner P.J. (Peter)
- Walker M. (Mark)
- Walley A. (Andrew)
- Walters G. (GBragi)
- Walters G.B. (Bragi)
- Ward K.L. (Kim L.)
- Wareham N.J. (Nick J.)
- Wareham N.J. (Nick)
- Wareham N.J. (Nick)
- Watanabe R.M. (Richard M.)
- Watanabe R.M. (Richard)
- Waterworth D. (Dawn)
- Waterworth D. (Dawn)
- Waterworth D.M. (Dawn)
- Watkins H. (Hugh)
- Weedon M.N. (Michael)
- Weedon M.N. (Michael)
- Welch R.P. (Ryan)
- Wheeler E. (Eleanor)
- Whitfield J. (John)
- Wichmann H.-E. (H.-Erich)
- Wichmann H.E. (H. Erich)
- Wichmann H.E. (Heinz Erich)
- Wichmann H.E. (Heinz Erich)
- Wijmenga C. (Cisca)
- Wild S.H. (Sarah)
- Willems van Dijk J.A.P. (Ko)
- Willems S.M. (Sara)
- Willems-vanDijk K. (Ko)
- Willemsen G.
- Willemsen G.A.H.M. (Gonneke)
- Willer C.J. (Cristen J.)
- Willer C.J. (Cristen)
- Williams G.H. (Gordon)
- Wilson J.F. (James F.)
- Wilson J.F. (James)
- Wilson J.G. (James G.)
- Winkler T.W. (Thomas W.)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline C. M.)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C. M.)
- Wong T.Y. (Tien Y.)
- Wood A.R. (Andrew)
- Wright A.F. (Alan)
- Wright A.F. (Alan)
- Wu G. (Guanming)
- Wu Y. (Ying)
- Yarnell J.W.G. (John W.)
- Yuan X. (Xin)
- Zabena C. (Carina)
- Zee R.Y.L. (Robert)
- Zeggini E. (Eleftheria)
- Zeggini E. (Eleftheria)
- Zelenika D. (Diana)
- Zethelius B. (Björn)
- Zhai G. (Guangju)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Zhao J.H. (Jing Hua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zwart J-A. (John-Anker)
- Ădonnell C.J. (Christopher)
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5Ă10â8- 1.2 Ă10â43). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3Ă10â4). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3Ă10â3, n = 22,044), increased triglycerides (p = 2.6Ă10â14, n = 93,440), increased waist-to-hip ratio (p = 1.8Ă10â5, n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4Ă10â3, n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL- cholesterol concentrations (p = 4.5Ă10â13, n = 96,748) and decreased BMI (p = 1.4Ă10â4, n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance
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