Association of plasma MMP8 levels with the extent of lymph node metastasis and risk of distant metastasis

note: controls + pN0 comprises healthy women and breast cancer patients without detectable lymph node or distant metastasis; pN1+pN2 comprises patients with moderate lymph node metastasis but without distant metastasis; pN3 comprises patients with extensive lymph node metastasis and a high risk of distant metastasis (box-whisker diagrams with median, 1quartile, 3quartile and non-outlier range).<p><b>Copyright information:</b></p><p>Taken from "Plasma MMP1 and MMP8 expression in breast cancer: Protective role of MMP8 against lymph node metastasis"</p><p>http://www.biomedcentral.com/1471-2407/8/77</p><p>BMC Cancer 2008;8():77-77.</p><p>Published online 20 Mar 2008</p><p>PMCID:PMC2278147.</p><p></p

Differences in plasma levels of MMP1 and MMP8 between patients with and without inflammatory breast cancer (box-whisker diagrams with median, 1quartile, 3quartile and non-outlier range)

<p><b>Copyright information:</b></p><p>Taken from "Plasma MMP1 and MMP8 expression in breast cancer: Protective role of MMP8 against lymph node metastasis"</p><p>http://www.biomedcentral.com/1471-2407/8/77</p><p>BMC Cancer 2008;8():77-77.</p><p>Published online 20 Mar 2008</p><p>PMCID:PMC2278147.</p><p></p

Additional file 7 of Immune-related 3-lncRNA signature with prognostic connotation in a multi-cancer setting

Additional file 7: Akaike information criterion (AIC), delta AIC, and HRs for death (overall survival) and corresponding 95%-confidence interval for ICR and 3 ir-lncRNA signature in 18 solid cancer TCGA datasets and RAQA cohort

Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestry

Breast cancer largely dominates the global cancer burden statistics; however, there are striking disparities in mortality rates across countries. While socioeconomic factors contribute to population-based differences in mortality, they do not fully explain disparity among women of African ancestry (AA) and Arab ancestry (ArA) compared to women of European ancestry (EA). In this study, we sought to identify molecular differences that could provide insight into the biology of ancestry-associated disparities in clinical outcomes. We applied a unique approach that combines the use of curated survival data from The Cancer Genome Atlas (TCGA) Pan-Cancer clinical data resource, improved single-nucleotide polymorphism-based inferred ancestry assignment, and a novel breast cancer subtype classification to interrogate the TCGA and a local Arab breast cancer dataset. We observed an enrichment of BasalMyo tumors in AA patients (38 vs 16.5% in EA, p = 1.30E − 10), associated with a significant worse overall (hazard ratio (HR) = 2.39, p = 0.02) and disease-specific survival (HR = 2.57, p = 0.03). Gene set enrichment analysis of BasalMyo AA and EA samples revealed differences in the abundance of T-regulatory and T-helper type 2 cells, and enrichment of cancer-related pathways with prognostic implications (AA: PI3K-Akt-mTOR and ErbB signaling; EA: EGF, estrogen-dependent and DNA repair signaling). Strikingly, AMPK signaling was associated with opposing prognostic connotation (AA: 10-year HR = 2.79, EA: 10-year HR = 0.34). Analysis of ArA patients suggests enrichment of BasalMyo tumors with a trend for differential enrichment of T-regulatory cells and AMPK signaling. Together, our findings suggest that the disparity in the clinical outcome of AA breast cancer patients is likely related to differences in cancer-related and microenvironmental features.Other Information Published in: npj Breast Cancer License: https://creativecommons.org/licenses/by/4.0See article on publisher's website: http://dx.doi.org/10.1038/s41523-021-00215-x</p

Additional file 9 of Immune-related 3-lncRNA signature with prognostic connotation in a multi-cancer setting

Additional file 9: Correlation of 3 ir-lncRNA signature with immune subpopulations across tumor types. Pearson correlation heatmap between immune cell subpopulation enrichment scores and 3 ir-lncRNA scores

Additional file 1: of Immune oncology, immune responsiveness and the theory of everything

List of individual genes and corresponding models related to immune suppression used for the Theory of Everything (TOE). (TXT 11 kb