Commentary on ESMA Guidelines on enforcement of financial information

The document responds to 20 questions posed by the European Securities and Markets Authority (ESMA) in Annex 1 of the Consultation Paper "ESMA Guidelines on enforcement of financial information

Acne resolution rates: Results of a single-blind, randomized, controlled, parallel phase III trial with EE/CMA (Belara (R)) and EE/LNG (Microgynon (R))

Background and Objective: Acne in women can often be successfully treated by the intake of oral contraceptives containing gestagens with anti-androgenic properties. This study aimed to evaluate the efficacy of the monophasic oral contraceptive ethinylestradiol/chlormadinone acetate (EE/CMA; Belara (R)) for the treatment of mild to moderate papulopustular acne of the face and acne-related disorders in comparison to EE/levonorgestrel (LNG; Microgynon (R)). Methods: 199 female acne patients were enrolled in a single-blind, randomized, multicentre phase III study and divided into two groups who received either EE/CMA or EE/LNG. The primary end point was fulfilled if the number of papules/pustules per half of the face present on admission had decreased by at least 50% in the 12th medication cycle. Results: 59.4% of the women under EE/CMA and 45.9% under EE/LNG were responders. The relative frequency of women with complete resolution was 16.5% under EE/CMA and 4.3% under EE/LNG at cycle 12. Conclusion: EE/CMA is an efficient treatment for women with mild and moderate papulopustular acne of the face and related disorders, reflecting the well-known anti-androgenic properties of the progestogen CMA. Copyright (C) 2001 S, Karger AG, Basel

Effects of Relaxation Therapy on Anxiety in Depressed Clients

During a psychiatric field placement, it was noted by this nurse researcher that patients with a diagnosis of depression often overtly displayed symptoms of anxiety. A brief literature review revealed that this anxiety-depression duality occurred frequently. The purpose of this study was to determine if relaxation therapy was a therapeutic intervention which could be utilized by nurses to provide relief from the symptoms of the anxiety-depression syndrome. This was a clinical, quasi-experimental research investigation. The sample was chosen by a purposive, non-random selection of 20 experimental and 10 control subjects who were hospitalized with a diagnosis of depression in an acute care psychiatric facility. Each subject was pretested utilizing the State-Trait Anxiety Inventory. The experimental group then engaged in six sessions of relaxation therapy, the morning and evening of three consecutive days. All subjects in both groups were post-tested for levels of anxiety at the end of the third day. The major supposition in this study was that there would be a significant decrease in anxiety in the experimental group, which received the relaxation therapeutic intervention, as compared to the control group, which received no treatment intervention. Minor suppositions were that levels of anxiety, diagnosis, age, sex, and medications would influence the study outcome. Statistical analysis of the research data revealed that subjects who engaged in the relaxation therapeutic intervention series showed a significant decrease in state anxiety as compared to the control subjects who did not participate in the relaxation series. Age and sex were not significant factors in state anxiety change scores in this research, indicating that subjects of both sexes, and all ages from 18 to 65 years may benefit from this therapy. Diagnosis was a significant factor. Psychotically depressed patients demonstrated a greater decrease in anxiety than did neurotically depressed patients or those with a deferred diagnosis of depression. Level of pretest state anxiety was a significant factor. High level pretest anxiety subjects displayed greater pre- to post-anxiety reduction than did low level pretest anxiety subjects. Medications, although a useful criterion for sample selection, proved to be a statistically inefficient factor to measure in this research study. From these findings it was concluded that for the group of subjects studied the intervention of progressive muscle relaxation therapy appeared to be an effective method of reducing anxiety in depressed patients. This method may have useful anxiety-reducing effects in other populations in the health care field. A major, unmeasured positive aspect of this therapy is that unlike the passivity of taking medications, progressive muscle relaxation, chosen for this study, required active engagement of the patient in the actual treatment. This could serve to increase the patient\u27s sense of responsibility, mastery and control in the treatment situation

Stellungnahme zu aktuellen Formulierungsvorschlägen für Änderungen am Deutschen Corporate Governance Kodex

Die Stellungnahme bezieht sich auf die aktuellen Formulierungsvorschläge für Änderungen am DCGK für börsennotierte deutsche Aktiengesellschaften aus den Plenarsitzungen der Regierungskommission vom 9. Januar und 31. Januar 2013. Der Text enthält zudem Anmerkungen zur Aufsichtsratvergütung, zur Besetzung des Prüfungsausschusses mit Financial Experts, zu Fragen der Mitbestimmung und zu Möglichkeiten der Bündelung der Corporate Governance Berichterstattung

Malignant melanoma in childhood

Maligni melanom je v otroški dobi zelo redka oblika malignega obolenja. Zanesljiva diagnoza pomeni izziv tako za kliniko kot za patohistologa. Čeprav oba postavita diagnozo melanom silno redko gre kljub vsemu nemalokrat v resnici za benigno pigmentno spremembo. Nekateri podatki in vprašanja v zvezi z melanomi v otroštvu so obravnavani v prispevku.Malignant melanoma in childhood is a very rare malignancy. The accurate diagnosis of melanoma in infants and children present a challenging problem for clinicians and pathologists. It is often "overdiagnosed". Some datas and questions are disscussed

Liddy Worret, Brustbild

Signatur des Originals: S 36/F07352Original eigenhändig signier

The siege of Yorktown, April 1862

Scale not given.LC Civil War Maps (2nd ed.), 673.7"Entered accord. to Act of Congress A.D. 1862 by C. Bohn in the Clerks Office of the District of Columbia."Bird's-eye view of the Union siege of Yorktown, with 23 places, batteries, ship positions, troop positions, and field headquarters keyed by number to list in lower margin.Description derived from published bibliography