Lesions impairing regular versus irregular past tense production

We investigated selective impairments in the production of regular and irregular past tense by examining language performance and lesion sites in a sample of twelve stroke patients. A disadvantage in regular past tense production was observed in six patients when phonological complexity was greater for regular than irregular verbs, and in three patients when phonological complexity was closely matched across regularity. These deficits were not consistently related to grammatical difficulties or phonological errors but were consistently related to lesion site. All six patients with a regular past tense disadvantage had damage to the left ventral pars opercularis (in the inferior frontal cortex), an area associated with articulatory sequencing in prior functional imaging studies. In addition, those that maintained a disadvantage for regular verbs when phonological complexity was controlled had damage to the left ventral supramarginal gyrus (in the inferior parietal lobe), an area associated with phonological short-term memory. When these frontal and parietal regions were spared in patients who had damage to subcortical (n = 2) or posterior temporo-parietal regions (n = 3), past tense production was relatively unimpaired for both regular and irregular forms. The remaining (12th) patient was impaired in producing regular past tense but was significantly less accurate when producing irregular past tense. This patient had frontal, parietal, subcortical and posterior temporo-parietal damage, but was distinguished from the other patients by damage to the left anterior temporal cortex, an area associated with semantic processing. We consider how our lesion site and behavioural observations have implications for theoretical accounts of past tense production

Individual differences in verbal short-term memory and reading aloud: Semantic compensation for weak phonological processing across tasks

According to contemporary accounts, linguistic behaviour reflects the interaction of distinct representations supporting word meaning and phonology. However, there is controversy about the extent to which this interaction occurs within task-specific systems, specialised for reading and short-term memory, as opposed to between components that support the full range of linguistic tasks. We examined whether individual differences in the efficiency of phonological processing would relate to the application of lexical-semantic knowledge to support verbal short-term memory, single word reading and repetition. In a sample of 83 participants we related nonword performance in each task (as a marker of phonological capacity in the absence of meaning) to the effects of word imageability (a lexical-semantic variable). We found stronger reliance on lexical-semantic knowledge in participants with weaker phonological processing. This relationship held across tasks, suggesting that lexical-semantic processing can compensate for phonological weakness which would otherwise give rise to poor performance. Our results are consistent with separable yet interacting primary systems for phonology and semantics, with lexical-semantic knowledge supporting pattern completion within the phonological system in a similar way across short-term memory and reading tasks

Impact of brain parcellation on prediction performance in models of cognition and demographics

Brain connectivity analysis begins with the selection of a parcellation scheme that will define brain regions as nodes of a network whose connections will be studied. Brain connectivity has already been used in predictive modelling of cognition, but it remains unclear if the resolution of the parcellation used can systematically impact the predictive model performance. In this work, structural, functional and combined connectivity were each defined with five different parcellation schemes. The resolution and modality of the parcellation schemes were varied. Each connectivity defined with each parcellation was used to predict individual differences in age, education, sex, executive function, self-regulation, language, encoding and sequence processing. It was found that low-resolution functional parcellation consistently performed above chance at producing generalisable models of both demographics and cognition. However, no single parcellation scheme showed a superior predictive performance across all cognitive domains and demographics. In addition, although parcellation schemes impacted the graph theory measures of each connectivity type (structural, functional and combined), these differences did not account for the out-of-sample predictive performance of the models. Taken together, these findings demonstrate that while high-resolution parcellations may be beneficial for modelling specific individual differences, partial voluming of signals produced by the higher resolution of the parcellation likely disrupts model generalisability

Opposing effects of semantic diversity in lexical and semantic relatedness decisions

Semantic ambiguity has often been divided into 2 forms: homonymy, referring to words with 2 unrelated interpretations (e.g., bark), and polysemy, referring to words associated with a number of varying but semantically linked uses (e.g., twist). Typically, polysemous words are thought of as having a fixed number of discrete definitions, or “senses,” with each use of the word corresponding to one of its senses. In this study, we investigated an alternative conception of polysemy, based on the idea that polysemous variation in meaning is a continuous, graded phenomenon that occurs as a function of contextual variation in word usage. We quantified this contextual variation using semantic diversity (SemD), a corpus-based measure of the degree to which a particular word is used in a diverse set of linguistic contexts. In line with other approaches to polysemy, we found a reaction time (RT) advantage for high SemD words in lexical decision, which occurred for words of both high and low imageability. When participants made semantic relatedness decisions to word pairs, however, responses were slower to high SemD pairs, irrespective of whether these were related or unrelated. Again, this result emerged irrespective of the imageability of the word. The latter result diverges from previous findings using homonyms, in which ambiguity effects have only been found for related word pairs. We argue that participants were slower to respond to high SemD words because their high contextual variability resulted in noisy, underspecified semantic representations that were more difficult to compare with one another. We demonstrated this principle in a connectionist computational model that was trained to activate distributed semantic representations from orthographic inputs. Greater variability in the orthography-to-semantic mappings of high SemD words resulted in a lower degree of similarity for related pairs of this type. At the same time, the representations of high SemD unrelated pairs were less distinct from one another. In addition, the model demonstrated more rapid semantic activation for high SemD words, thought to underpin the processing advantage in lexical decision. These results support the view that polysemous variation in word meaning can be conceptualized in terms of graded variation in distributed semantic representations

When does less yield more? The impact of severity upon implicit recognition in pure alexia

Pure alexia (PA) is characterised by strong effects of word length on reading times and is sometimes accompanied by an overt letter-by-letter (LBL) reading strategy. Past studies have reported “implicit recognition” in some individual PA patients. This is a striking finding because such patients are able to perform semantic classification and lexical decision at above chance levels even when the exposure duration is short enough to prevent explicit identification. In an attempt to determine the prevalence of this “implicit recognition” effect, we assessed semantic categorisation and lexical decision performance using limited exposure durations in 10 PA cases. The majority of the patients showed above chance accuracy in semantic categorisation and lexical decision. Performance on the lexical decision test was influenced by frequency and imageability. In addition, we found that the extent to which patients showed evidence of “implicit recognition” in both tasks was inversely related to the severity of their reading disorder. This result is consistent with hypotheses which suggest that this effect does not constitute an implicit form of unique word identification but is a reflection of the degree of partial activation within the word recognition system. These results also go some way toward explaining the individual variation in the presence of this effect observed across previous case-study investigations in the literature