6 research outputs found
On Classical Equivalence Between Noncritical and Einstein Gravity : The AdS/CFT Perspectives
We find that noncritical gravity, a special class of higher derivative
gravity, is classically equivalent to Einstein gravity at the full nonlinear
level. We obtain the viscosity-to-entropy ratio and the second order transport
coefficients of the dual fluid of noncritical gravity to all orders in the
coupling of higher derivative terms. We also compute the holographic
entanglement entropy in the dual CFT of noncritical gravity. All these results
confirm the nonlinear equivalence between noncritical gravity and Einstein
gravity at the classical level.Comment: 19 pages, no figure
Noncritical Einstein-Weyl Gravity and the AdS/CFT Correspondence
We explore four-dimensional Einstein-Weyl gravity and supergravity on anti-de
Sitter spacetime. For a specific range of the coupling with appropriate
boundary conditions, we show the effective equivalence of the theory with
Einstein gravity and AdS supergravity at the quadratic Lagrangian level.
Furthermore we show that these equivalences can be promoted to the full
nonlinear level. We also show that the similar behavior holds for the
generalized Gibbons-Hawking terms. From this we find that the correlation
functions in the dual conformal field theory of Einstein-Weyl gravity and
supergravity can be readily read off from corresponding ones from Einstein
gravity and AdS supergravity. We also give comments on some issues in critical
gravity and supergravity as well as conformal gravity and supergravity.Comment: 20 pages, 1 figure: v2, references and footnote added, typos
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APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE ε4 on Alzheimer's Disease Risk in a Multiracial Sample
Variants in the APOE gene region may explain ethnic differences in the association of Alzheimer's disease (AD) with ε4. Ethnic differences in allele frequencies for three APOE region SNPs (single nucleotide polymorphisms) were identified and tested for association in 19,398 East Asians (EastA), including Koreans and Japanese, 15,836 European ancestry (EuroA) individuals, and 4985 African Americans, and with brain imaging measures of cortical atrophy in sub-samples of Koreans and EuroAs. Among ε4/ε4 individuals, AD risk increased substantially in a dose-dependent manner with the number of APOE promoter SNP rs405509 T alleles in EastAs (TT: OR (odds ratio) = 27.02, p = 8.80 × 10-94; GT: OR = 15.87, p = 2.62 × 10-9) and EuroAs (TT: OR = 18.13, p = 2.69 × 10-108; GT: OR = 12.63, p = 3.44 × 10-64), and rs405509-T homozygotes had a younger onset and more severe cortical atrophy than those with G-allele. Functional experiments using APOE promoter fragments demonstrated that TT lowered APOE expression in human brain and serum. The modifying effect of rs405509 genotype explained much of the ethnic variability in the AD/ε4 association, and increasing APOE expression might lower AD risk among ε4 homozygotes