14 research outputs found
Intracranial Dural Metastasis of Ewing's Sarcoma: a Case Report
Although intracranial dural metastasis of Ewing's sarcoma is a very rare finding, its imaging characteristics are similar to those of its primary form in the central nervous system. Thus, this tumor must be considered in the differential diagnosis of extra-axial dural masses
The Expression of ERCC1, RRM1, and BRCA1 in Breast Cancer According to the Immunohistochemical Phenotypes
We studied the expression of BRCA1, ERCC1, and RRM1 which play an important role in DNA repair systems in breast cancer. Immunohistochemical staining for EGFR, BRCA1, ERCC1, and RRM1 were performed by using a tissue microarray made from 230 breast cancer patients. Patients were classified into luminal A, luminal B, HER-2, and triple negative breast cancer (TNBC) types according to ER, PR, and HER-2 expression. The expression of ERCC1, RRM1, and BRCA1 were correlated (P < 0.05). The expression level of ERCC1 was the lowest in TNBC type (P = 0.031), ERCC1 negativity was more prominent in TNBC and luminal B groups than luminal A and HER-2 groups (P = 0.013). Cases with EGFR overexpression showed high expression of RRM1 and BRCA1 (P = 0.046, and 0.004, respectively). In conclusion, the expression of ERCC1 is particularly lower in TNBCs than other types of breast cancers
Impact of Grade, Hormone Receptor, and HER-2 Status in Women with Breast Cancer on Response to Specific Chemotherapeutic Agents by in vitro Adenosine Triphosphate-based Chemotherapy Response Assay
This study was designed to assess whether histological and biological factors of breast cancer can predict chemoresponse to specific agents. Adenosine triphosphate-based chemotherapy response assay (ATP-CRA) was employed to retrieve chemoresponse to 5-fluorouracil (5-FU), doxetaxel, doxorubicin, epirubicin, and paclitaxel in 49 patients. Tumors with high histologic and nuclear grade have higher response rate to doxorubicin (P<0.05) and palitaxel (P<0.05). Estrogen receptor (ER)-negative tumors respond well to doxorubicin (P=0.038), and progesterone receptor (PR)-negative tumors to 5-FU (P=0.039), doxetaxel (P=0.038), doxorubicin (P=0.000), epirubicin (P=0.010), and paclitaxel (P=0.003). Among the breast cancer subtypes determined by ER, PR, and HER-2 immunohistochemical stains, the HER-2+/ER- subtype has a higher response rate to doxorubicin (P=0.008). This in vitro result suggests that the combination of histologic and nuclear grade, hormone receptor, and HER-2 status can be a predictive factor of response to specific chemotherapy agents. Further in vivo study should be followed for clinical trials
Clinicopathlogic and Immunohistochemical Characteristics of Triple Negative Invasive Lobular Carcinoma
∙ The authors have no financial conflicts of interest. © Copyright: Yonsei University College of Medicine 2011 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Licens
The expression of succinate dehydrogenase in breast phyllodes tumor
The purpose of this study is to investigate the
expression of succinate dehydrogenase (SDH)A, SDHB,
and HIF-1α in phyllodes tumors and the association with
clinic-pathologic factors. Using tissue microarray
(TMA) for 206 phyllodes tumor cases, we performed
immunohistochemical stains for SDHA, SDHB, and
HIF-1α and analyzed their expression in regard to
clinicopathologic parameters of each case. The cases
were comprised of 156 benign, 34 borderline, and 16
malignant phyllodes tumors. The expression of stromal
SDHA and epithelial- and stromal- SDHB increased as
the tumor progressed from benign to malignant
(P<0.001). There were five stromal SDHA-negative
cases and 31 stromal SDHB-negative cases. SDHB
negativity was associated with a lower histologic grade
(P=0.054) and lower stromal atypia (P=0.048).
Univariate analysis revealed that a shorter disease free
survival (DFS) was associated with stromal SDHB highpositivity (P=0.013) and a shorter overall survival (OS)
was associated with high-positivity of stromal SDHA
and SDHB (P<0.001 and P<0.001, respectively). The
multivariate Cox analysis with the variables stromal
cellularity, stromal atypia, stromal mitosis, stromal
overgrowth, tumor margin, stromal SDHA expression,
and stromal SDHB expression revealed that stromal
overgrowth was associated with a shorter DFS (hazard
ratio: 24.78, 95% CI: 3.126-196.5, P=0.002) and a
shorter OS (hazard ratio: 176.7, 95% CI: 8.466-3691,
P=0.001). In conclusion, Tumor grade is positively
correlated with SDHA and SDHB expression in the
tumor stroma in phyllodes tumors of the breast. This
result may be attributed to the increased metabolic
demand in high grade tumors