Early communication abilities of 24-month-old children with Williams syndrome as measured by the Communication Complexity Scale.

Williams syndrome (WS) is a neurodevelopmental disorder associated with intellectual disability accompanied by a distinct cognitive profile. Despite their socially outgoing nature, children with WS exhibit delayed communication development and specific deficits across various functions of communication. The purpose of this study was to describe the range of communication complexity observed in 24-month-olds with WS and determine relations between communication complexity and other areas of cognitive development. The communication complexity of 17 24-month-old children with WS was measured using the Communication Complexity Scale (CCS), which quantifies optimal and typical communication complexity, as well as optimal communication for Joint Attention (JA) and Behavior Regulation (BR) functions. Other aspects of development were measured using the Mullen Scales of Early Learning (MSEL), MacArthur–Bates Communicative Development Inventory (CDI), and language measures derived from a naturalistic play session with the child’s mother. A wide range of communication complexity was observed, from dual and triadic orientations to multiple-word phrases. Communication complexity was significantly and strongly correlated with expressive and receptive language, fine motor skills, overall cognitive development, expressive vocabulary size, and language abilities in a naturalistic setting. The findings indicated that the CCS is a valid measure of communication complexity in young children with WS and could be used as a diagnostic tool to identify intervention goals and measure the effectiveness of implementation of intervention techniques targeting communication development

Development of Algorithms and Criteria for Continuous Condition Monitoring of Railroad Bearings

This thesis summarizes research conducted at the University of Texas-Pan American to investigate the implementation of condition monitoring algorithms for use with railway roller bearings equipped with wireless temperature sensor nodes. Current temperature based condition monitoring techniques utilize wayside detection equipment intermittently located along the track to garner sporadic bearing cup temperatures. Such devices are not capable of detecting brief transient temperature trending events. The developed algorithms were tested using a fleet of ten railway freight cars instrumented with wireless sensor nodes and operated by an Australian freight transportation company. Eighteen months of continuous monitoring combined with the inspection of three setout bearings demonstrate the effectiveness and accuracy of the developed algorithms as a continuous bearing health monitoring system

Distance constraints on activation of TRPV4 channels by AKAP150-bound PKCα in arterial myocytes.

TRPV4 (transient receptor potential vanilloid 4) channels are Ca2+-permeable channels that play a key role in regulating vascular tone. In arterial myocytes, opening of TRPV4 channels creates local increases in Ca2+ influx, detectable optically as "TRPV4 sparklets." TRPV4 sparklet activity can be enhanced by the action of the vasoconstrictor angiotensin II (AngII). This modulation depends on the activation of subcellular signaling domains that comprise protein kinase C α (PKCα) bound to the anchoring protein AKAP150. Here, we used super-resolution nanoscopy, patch-clamp electrophysiology, Ca2+ imaging, and mathematical modeling approaches to test the hypothesis that AKAP150-dependent modulation of TRPV4 channels is critically dependent on the distance between these two proteins in the sarcolemma of arterial myocytes. Our data show that the distance between AKAP150 and TRPV4 channel clusters varies with sex and arterial bed. Consistent with our hypothesis, we further find that basal and AngII-induced TRPV4 channel activity decays exponentially as the distance between TRPV4 and AKAP150 increases. Our data suggest a maximum radius of action of ∼200 nm for local modulation of TRPV4 channels by AKAP150-associated PKCα

How looking only at policy diffusion "successes" between states may be misleading

Ideas often have a way of spreading. This is certainly true in the case of American states; innovative policies are often adopted by others in a process known as policy diffusion. But in trying to determine which policies spread, could we be giving too much of a focus on those that are successful? In new research which examines interstate compacts, Andrew Karch, Sean C. Nicholson-Crotty, Neal D. Woods, and Ann O’M. Bowman find that an emphasis on successful policies may be leading scholars to overestimate the importance of some factors, such as neighboring state activity, and underestimate the importance of others, like the number of previous adopters

On-Line Realtime Water Quality Monitoring and Control for Swimming Pools

Effective swimming pool water quality monitoring and control systems are important to safeguard public health and for bather comfort. Most Irish swimming pool monitoring systems rely heavily on manual methods for sampling, testing and data recording of important parameters. Microbiological testing is infrequent and results can often take days. The goal of this research is to develop a water quality monitoring and control system with real time data logging, automatic data analysis, remote monitoring and control, microbiological sampling capabilities and online connectivity. National Instruments hardware and its software package LabView form the basis of the monitoring and control system. Several sensors measure the main water parameters affecting disinfection and overall water balance: temperature, pH level, total dissolved solids, turbidity, chlorine level and redox potential. Water hardness is measured manually due to the prohibitive cost of an automatic system. The LabView package and related hardware controls the chemical dosing of the pool in order to maintain these parameters within their recommended optimum levels. An investigation is also being carried out into the development of a biosensor to detect E. coli, as it is the best indicator of faecal contamination in water. The flexibility of the technology used in this research means that it has numerous other potential applications, such as: drinking water treatment, waste water treatment, industrial process control, environmental study and monitoring

How does the preference for increasing payments depend on the size and source of the payments?

It is well-known that subjects can exhibit a preference for increasing payments. Smith (2009a) makes a related prediction that the difference between the preference increasing wage payments and the preference for increasing non-wage payments will be largest for intermediate payments. We find evidence consistent with this prediction. Consistent with previous experiments, we find that the preference for increasing payments is increasing in the size of the payments. Also consistent with the literature, we find that the preference for increasing wage payments is stronger than the preference for non-wage payments

How does the preference for increasing payments depend on the size and source of the payments?

It is well-known that subjects can exhibit a preference for increasing payments. Smith (2009a) makes a related prediction that the difference between the preference increasing wage payments and the preference for increasing non-wage payments will be largest for intermediate payments. We find evidence consistent with this prediction. Consistent with previous experiments, we find that the preference for increasing payments is increasing in the size of the payments. Also consistent with the literature, we find that the preference for increasing wage payments is stronger than the preference for non-wage payments

Anticoagulant rodenticides on our public and community lands: spatial distribution of exposure and poisoning of a rare forest carnivore.

Anticoagulant rodenticide (AR) poisoning has emerged as a significant concern for conservation and management of non-target wildlife. The purpose for these toxicants is to suppress pest populations in agricultural or urban settings. The potential of direct and indirect exposures and illicit use of ARs on public and community forest lands have recently raised concern for fishers (Martes pennanti), a candidate for listing under the federal Endangered Species Act in the Pacific states. In an investigation of threats to fisher population persistence in the two isolated California populations, we investigate the magnitude of this previously undocumented threat to fishers, we tested 58 carcasses for the presence and quantification of ARs, conducted spatial analysis of exposed fishers in an effort to identify potential point sources of AR, and identified fishers that died directly due to AR poisoning. We found 46 of 58 (79%) fishers exposed to an AR with 96% of those individuals having been exposed to one or more second-generation AR compounds. No spatial clustering of AR exposure was detected and the spatial distribution of exposure suggests that AR contamination is widespread within the fisher's range in California, which encompasses mostly public forest and park lands Additionally, we diagnosed four fisher deaths, including a lactating female, that were directly attributed to AR toxicosis and documented the first neonatal or milk transfer of an AR to an altricial fisher kit. These ARs, which some are acutely toxic, pose both a direct mortality or fitness risk to fishers, and a significant indirect risk to these isolated populations. Future research should be directed towards investigating risks to prey populations fishers are dependent on, exposure in other rare forest carnivores, and potential AR point sources such as illegal marijuana cultivation in the range of fishers on California public lands