AML risk stratification models utilizing ELN-2017 guidelines and additional prognostic factors: a SWOG report.

Background: The recently updated European LeukemiaNet risk stratification guidelines combine cytogenetic abnormalities and genetic mutations to provide the means to triage patients with acute myeloid leukemia for optimal therapies. Despite the identification of many prognostic factors, relatively few have made their way into clinical practice. Methods: In order to assess and improve the performance of the European LeukemiaNet guidelines, we developed novel prognostic models using the biomarkers from the guidelines, age, performance status and select transcript biomarkers. The models were developed separately for mononuclear cells and viable leukemic blasts from previously untreated acute myeloid leukemia patients (discovery cohort, Results: Models using European LeukemiaNet guidelines were significantly associated with clinical outcomes and, therefore, utilized as a baseline for comparisons. Models incorporating age and expression of select transcripts with biomarkers from European LeukemiaNet guidelines demonstrated higher area under the curve and C-statistics but did not show a substantial improvement in performance in the validation cohort. Subset analyses demonstrated that models using only the European LeukemiaNet guidelines were a better fit for younger patients (age \u3c 55) than for older patients. Models integrating age and European LeukemiaNet guidelines visually showed more separation between risk groups in older patients. Models excluding results for Conclusions: While European LeukemiaNet guidelines remain a critical tool for triaging patients with acute myeloid leukemia, the findings illustrate the need for additional prognostic factors, including age, to improve risk stratification

Distribution of dissolved pesticides and other water quality constituents in small streams, and their relation to land use, in the Willamette River Basin, Oregon, 1996 /

Shipping list no.: 98-0141-P.Includes bibliographical references (p. 63-66).Mode of access: Internet

Dinheiro, poder e sexo Money, power, and sex

A crença generalizada de que o dinheiro corrompe a intimidade bloqueia nossa capacidade de descrever e explicar como dinheiro, poder, e sexo, de fato, interagem. A crença oposta - de que o sexo funciona como uma mercadoria como qualquer outra - não é melhor para ajudar descrições e explicações. A intersecção de sexo, dinheiro e poder, de fato, gera confusão e conflito, mas isso ocorre precisamente porque os participantes estão simultaneamente negociando relações interpessoais delicadas e responsáveis e marcando diferenças entre essas relações e outras com as quais elas poderiam ser fácil e perigosamente confundidas. Na vida cotidiana, as pessoas lidam com essas dificuldades com um conjunto de práticas que poderíamos chamar de "Boas Combinações".<br>Widespread beliefs that money corrupts intimacy block our ability to describe and explain how money, power, and sex actually interact. The opposite belief - that sex operates like an ordinary market commodity - serves description and explanation no better. The intersection of sex, money, and power, does indeed generate confusion and conflict, but that is precisely because participants are simultaneously negotiating delicate, consequential, interpersonal relations and marking differences between those relations and others with which they could easily and dangerously be confused. In everyday social life, people deal with these difficulties by relying on a set of practices we can call good matches