Adaptive sampling in context-aware systems: a machine learning approach

As computing systems become ever more pervasive, there is an increasing need for them to understand and adapt to the state of the environment around them: that is, their context. This understanding comes with considerable reliance on a range of sensors. However, portable devices are also very constrained in terms of power, and hence the amount of sensing must be minimised. In this paper, we present a machine learning architecture for context awareness which is designed to balance the sampling rates (and hence energy consumption) of individual sensors with the significance of the input from that sensor. This significance is based on predictions of the likely next context. The architecture is implemented using a selected range of user contexts from a collected data set. Simulation results show reliable context identification results. The proposed architecture is shown to significantly reduce the energy requirements of the sensors with minimal loss of accuracy in context identification

Anthocyanins protect the gastrointestinal tract from high fat diet-induced alterations in redox signaling, barrier integrity and dysbiosis.

The gastrointestinal (GI) tract can play a critical role in the development of pathologies associated with overeating, overweight and obesity. We previously observed that supplementation with anthocyanins (AC) (particularly glycosides of cyanidin and delphinidin) mitigated high fat diet (HFD)-induced development of obesity, dyslipidemia, insulin resistance and steatosis in C57BL/6J mice. This paper investigated whether these beneficial effects could be related to AC capacity to sustain intestinal monolayer integrity, prevent endotoxemia, and HFD-associated dysbiosis. The involvement of redox-related mechanisms were further investigated in Caco-2 cell monolayers. Consumption of a HFD for 14 weeks caused intestinal permeabilization and endotoxemia, which were associated with a decreased ileum expression of tight junction (TJ) proteins (occludin, ZO-1 and claudin-1), increased expression of NADPH oxidase (NOX1 and NOX4) and NOS2 and oxidative stress, and activation of redox sensitive signals (NF-κB and ERK1/2) that regulate TJ dynamics. AC supplementation mitigated all these events and increased GLP-2 levels, the intestinal hormone that upregulates TJ protein expression. AC also prevented, in vitro, tumor necrosis factor alpha-induced Caco-2 monolayer permeabilization, NOX1/4 upregulation, oxidative stress, and NF-κB and ERK activation. HFD-induced obesity in mice caused dysbiosis and affected the levels and secretion of MUC2, a mucin that participates in intestinal cell barrier protection and immune response. AC supplementation restored microbiota composition and MUC2 levels and distribution in HFD-fed mice. Thus, AC, particularly delphinidin and cyanidin, can preserve GI physiology in HFD-induced obesity in part through redox-regulated mechanisms. This can in part explain AC capacity to mitigate pathologies, i.e. insulin resistance and steatosis, associated with HFD-associated obesity

cDNA-RNA subtractive hybridization reveals increased expression of mycocerosic acid synthase in intracellular Mycobacterium bovis BCG.

Identifying genes that are differentially expressed by Mycobacterium bovis BCG after phagocytosis by macrophages will facilitate the understanding of the molecular mechanisms of host cell-intracellular pathogen interactions. To identify such genes a cDNA-total RNA subtractive hybridization strategy has been used that circumvents the problems both of limited availability of bacterial RNA from models of infection and the high rRNA backgrounds in total bacterial RNA. The subtraction products were used to screen a high-density gridded Mycobacterium tuberculosis genomic library. Sequence data were obtained from 19 differential clones, five of which contained overlapping sequences for the gene encoding mycocerosic acid synthase (mas). Mas is an enzyme involved in the synthesis of multi-methylated long-chain fatty acids that are part of phthiocerol dimycocerosate, a major component of the complex mycobacterial cell wall. Northern blotting and primer extension data confirmed up-regulation of mas in intracellular mycobacteria and also revealed a putative extended -10 promoter structure and a long untranslated upstream region 5' of the mas transcripts, containing predicted double-stranded structures. Furthermore, clones containing overlapping sequences for furB, groEL-2, rplE and fadD28 were identified and the up-regulation of these genes was confirmed by Northern blot analysis. The cDNA-RNA subtractive hybridization enrichment and high density gridded library screening, combined with selective extraction of bacterial mRNA represents a valuable approach to the identification of genes expressed during intra-macrophage residence for bacteria such as M. bovis BCG and the pathogenic mycobacterium, M. tuberculosis

Differential effects of dietary supplements on metabolomic profile of smokers versus non-smokers.

BackgroundCigarette smoking is well-known to associate with accelerated skin aging as well as cardiovascular disease and lung cancer, in large part due to oxidative stress. Because metabolites are downstream of genetic variation, as well as transcriptional changes and post-translational modifications of proteins, they are the most proximal reporters of disease states or reversal of disease states.MethodsIn this study, we explore the potential effects of commonly available oral supplements (containing antioxidants, vitamins and omega-3 fatty acids) on the metabolomes of smokers (n = 11) compared to non-smokers (n = 17). At baseline and after 12 weeks of supplementation, metabolomic analysis was performed on serum by liquid and gas chromatography with mass spectroscopy (LC-MS and GC-MS). Furthermore, clinical parameters of skin aging, including cutometry as assessed by three dermatologist raters blinded to subjects' age and smoking status, were measured.ResultsLong-chain fatty acids, including palmitate and oleate, decreased in smokers by 0.76-fold (P = 0.0045) and 0.72-fold (P = 0.0112), respectively. These changes were not observed in non-smokers. Furthermore, age and smoking status showed increased glow (P = 0.004) and a decrease in fine wrinkling (P = 0.038). Cutometry showed an increase in skin elasticity in smokers (P = 0.049) but not in non-smokers. Complexion analysis software (VISIA) revealed decreases in the number of ultraviolet spots (P = 0.031), and cutometry showed increased elasticity (P = 0.05) in smokers but not non-smokers.ConclusionsAdditional future work may shed light on the specific mechanisms by which long-chain fatty acids can lead to increased glow, improved elasticity measures and decreased fine wrinkling in smokers' skin. Our study provides a novel, medicine-focused application of available metabolomic technology to identify changes in sera of human subjects with oxidative stress, and suggests that oral supplementation (in particular, commonly available antioxidants, vitamins and omega-3 fatty acids) affects these individuals in a way that is unique (compared to non-smokers) on a broad level

Sonification of Kepler Field SU UMa Cataclysmic Variable Stars V344 Lyr and V1504 Cyg

Sonification is the conversion of quantitative data into sound. In this work we explain the methods used in the sonification of light curves provided by the Kepler instrument from Q2 through Q6 for the cataclysmic variable systems V344 Lyr and V1504 Cyg . Both systems are SU UMa stars showing dwarf nova outbursts and superoutbursts as well as positive and negative superhumps. Focused sonifications were done from average pulse shapes of each superhump, and separate sonifications of the full, residual light curves were done for both stars. The audio of these data reflected distinct patterns within the evolutions of supercycles and superhumps that matched pervious observations and proved to be effective aids in data analysis

Obtaining New Insights for Biodiversity Conservation from Broad-Scale Citizen Science Data

Increasing public engagement in volunteer science1, either through data collection2 or processing3, is both raising public awareness of science and gathering useful information for scientists. While the payoffs of citizen science4 are potentially large, achieving them requires new approaches to data management and analysis that can only result from strong cross-disciplinary collaborations. This is especially true in ecology and conservation biology, where historically the understanding of species’ responses to environmental change has been constrained by the limited spatial5 or temporal scale6 of available data. Here we describe collaborative research in ecology, computer science, and statistics to generate essential information for conservation management of North American birds: accurate dynamic bird distributions models based on habitat associations across much of North America. Unique is our ability to describe the broad-scale dynamics of seasonal bird distributions and the associated seasonal patterns of habitat use. Our source of bird distribution data is eBird7, an online bird checklist program that currently gathers more than 74,000 checklists monthly from a large network of contributors. Our results were made possible through a data intensive scientific workflow8 that includes analytical methods merged from the fields of machine learning and statistics. We believe that this novel approach of data collection, synthesis, analysis, and visualization will serve as a hallmark for future research initiatives, with broad applicability across many scientific domains

An EUV Study of the Intermediate Polar EX Hydrae

On 2000 May 5, we began a large multi-wavelength campaign to study the intermediate polar, EX Hydrae. The simultaneous observations from six satellites and four telescopes were centered around a one million second observation with EUVE. Although EX Hydrae has been studied previously with EUVE, our higher signal-to-noise observations present new results and challenge the current IP models. Previously unseen dips in the light curve are reminiscent of the stream dips seen in polar light curves. Also of interest is the temporal extent of the bulge dip; approximately 0.5 in phase, implying that the bulge extends over half of the accretion disk. We propose that the magnetic field in EX Hydrae is strong enough (a few MG) to begin pulling material directly from the outer edge of the disk, thereby forming a large accretion curtain which would produce a very broad bulge dip. This would also result in magnetically controlled accretion streams originating from the outer edge of the disk. We also present a period analysis of the photometric data which shows numerous beat frequencies with strong power and also intermittent and wandering frequencies, an indication that physical conditions within EX Hya changed over the course of the observation. Iron spectral line ratios give a temperature of log T=6.5-6.9 K for all spin phases and a poorly constrained density of n_e=10^10-10^11 cm^-3 for the emitting plasma. This paper is the first in a series detailing our results from this multi-wavelength observational campaign.Comment: 27 pages, 7 figures, accepted for publication in Ap

Serendipitous Kepler observations of a background dwarf nova of SU UMa type

We have discovered a dwarf nova (DN) of type SU UMa in Kepler data which is 7.0 arcsec from the G-type exoplanet survey target KIC 4378554. The DN appears as a background source in the pixel aperture of the foreground G star. We extracted only the pixels where the DN is present and observed the source to undergo five outbursts -- one a superoutburst -- over a timespan of 22 months. The superoutburst was triggered by a normal outburst, a feature that has been seen in all DNe superoutburst observed by Kepler. Superhumps during the super outburst had a period of 1.842+/-0.004 h and we see a transition from disc-dominated superhump signal to a mix of disc and accretion stream impact. Predictions of the number of DNe present in Kepler data based on previously published space densities vary from 0.3 to 258. An investigation of the background pixels targets would lead to firmer constraints on the space density of DN.Comment: Accepted for publication in MNRA

The Grizzly, February 5, 1988

Cavorting Cop Caught • Lewis Disclaims Labels at Forum • Rock\u27N America • Patterns Campaign Nears Completion • Hockey Held as Hokey • Contra-versial Censorship Irks Student • History Department Interviews a New Way • Concert Features Christian Music • Summer Study in France a Fun-do • Notes: R.A. Rap Session Announced; Presidency Probers Convene; ALF Re-runs Rewarding; Child Safety Course Offered • Men\u27s Hoopsters Suffer Temporary Setback • Track Team Making Great Strides • Record Books Rewritten • U.C. Matters: Wrestling Tough and Confident • Men \u27Mers Holding Their Ownhttps://digitalcommons.ursinus.edu/grizzlynews/1203/thumbnail.jp