3,095 research outputs found
A Qualitative Examination of Optimal Professional Traits of Physical Therapists. – An Exploratory Investigation
Physical therapists are constantly searching for aspects of their professional practice to improve, in order to enhance interactions with patients, eventually leading to a more successful practice (Resnek & Jensen, 2003). Although this is the case, limited research has been found which has examined optimal qualities of physical therapists from neither a qualitative perspective, nor based upon their location. Thus, the purpose of this study is to use a qualitative approach to describe optimal qualities necessary for a successful physical therapy practice. In addition, this study aims to determine if therapists practicing in a rural community describe different qualities than therapists practicing in a metropolitan area. The study found that effective communication skills, deeper relationships, vast knowledge and the ability to teach it, a motivating mentality and a calm demeanor are essential professional traits for physical therapists. There were no major differences in professional traits between rural and metropolitan areas
Advances in environmental radiation protection: re-thinking animal-environment interaction modelling for wildlife dose assessment
Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases
Objective:
To examine the utility of the new Movement Disorder Society (MDS) diagnostic criteria in a large cohort of Parkinson's disease (PD) patients.
Methods:
Recently diagnosed (<3.5 years) PD cases fulfilling United Kingdom (UK) brain bank criteria in Tracking Parkinson's, a UK multicenter prospective natural history study were assessed by retrospective application of the MDS criteria.
Results:
In 2000 cases, 1835 (91.7%) met MDS criteria for PD, either clinically established (n = 1261, 63.1%) or clinically probable (n = 574, 28.7%), leaving 165 (8.3%) not fulfilling criteria. Clinically established cases were significantly more likely to have limb rest tremor (89.3%), a good l-dopa response (79.5%), and olfactory loss (71.1%), than clinically probable cases (60.6%, 44.4%, and 34.5% respectively), but differences between probable PD and ‘not PD’ cases were less evident. In cases not fulfilling criteria, the mean MDS UPDRS3 score (25.1, SD 13.2) was significantly higher than in probable PD (22.3, SD 12.7, p = 0.016) but not established PD (22.9, SD 12.0, p = 0.066). The l-dopa equivalent daily dose of 341 mg (SD 261) in non-PD cases was significantly higher than in probable PD (250 mg, SD 214, p < 0.001) and established PD (308 mg, SD 199, p = 0.025). After 30 months' follow-up, 89.5% of clinically established cases at baseline remained as PD (established/probable), and 86.9% of those categorized as clinically probable at baseline remained as PD (established/probable). Cases not fulfilling PD criteria had more severe parkinsonism, in particular relating to postural instability, gait problems, and cognitive impairment.
Conclusion:
Over 90% of cases clinically diagnosed as early PD fulfilled the MDS criteria for PD. Those not fulfilling criteria may have an atypical parkinsonian disorder or secondary parkinsonism that is not correctly identified by the UK Brain Bank criteria, but possibly by the new criteria
Improved nuclear localization of DNA-binding polyamides
Regulation of endogenous genes by DNA-binding polyamides requires effective nuclear localization. Previous work employing confocal microscopy to study uptake of fluorophore-labeled polyamides has demonstrated the difficulty of predicting a priori the nuclear uptake of a given polyamide. The data suggest that dye identity influences uptake sufficiently such that a dye-conjugate cannot be used as a proxy for unlabeled analogs. Polyamides capable of nuclear localization unaided by fluorescent dyes are desirable due to size and other limitations of fluorophores. Recently, a polyamide-fluorescein conjugate targeted to the hypoxia response element (HRE) was found to inhibit vascular endothelial growth factor (VEGF) expression in cultured HeLa cells. The current study uses inhibition of VEGF expression as a biological read-out for effective nuclear localization of HRE-targeted polyamides. We synthesized a focused library of non-fluorescent, HRE-targeted polyamides in which the C-terminus ‘tail’ has been systematically varied. Members of this library bind the HRE with affinities comparable or superior to that of the fluorescein-labeled analog. Although most library members demonstrate modest or no biological activity, two non-fluorescent polyamides are reported with activity rivaling that of the previously reported fluorescein-labeled polyamide. We also show evidence that promoter occupancy by HIF-1, the transcription factor that binds the HRE, is inhibited by HRE-targeted polyamides
Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease
Funded by Parkinson's UK National Institute for Health Research (NIHR) DeNDRoN network NIHR Newcastle Biomedical Research Unit Newcastle University NIHR funded Biomedical Research Centre in CambridgePeer reviewedPublisher PD
Preliminary investigation of the influence of dopamine regulating genes on social working memory
Working memory (WM) refers to mental processes that enable temporary retention and manipulation of information, including information about other people (“social working memory”). Previous studies have demonstrated that nonsocial WM is supported by dopamine neurotransmission. Here, we investigated in 131 healthy adults whether dopamine is similarly involved in social WM by testing whether social and nonsocial WM are influenced by genetic variants in three genes coding for molecules regulating the availability of dopamine in the brain: catechol-O-methyltransferase (COMT), dopamine active transporter (DAT), and monoamine-oxidase A (MAOA). An advantage for the Met allele of COMT was observed in the two standard WM tasks and in the social WM task. However, the influence of COMT on social WM performance was not accounted for by its influence on either standard WM paradigms. There was no main effect of DAT1 or MAOA, but a significant COMT x DAT1 interaction on social WM performance. This study provides novel preliminary evidence of effects of genetic variants of the dopamine neurotransmitter system on social cognition. The results further suggest that the effects observed on standard WM do not explain the genetic effects on effortful social cognition
White Dwarfs in Globular Clusters: HST Observations of M4
Using WFPC2 on the Hubble Space Telescope, we have isolated a sample of 258
white dwarfs (WDs) in the Galactic globular cluster M4. Fields at three radial
distances from the cluster center were observed and sizeable WD populations
were found in all three. The location of these WDs in the color-magnitude
diagram, their mean mass of 0.51()M, and their luminosity
function confirm basic tenets of stellar evolution theory and support the
results from current WD cooling theory. The WDs are used to extend the cluster
main-sequence mass function upward to stars that have already completed their
nuclear evolution. The WD/red dwarf binary frequency in M4 is investigated and
found to be at most a few percent of all the main-sequence stars. The most
ancient WDs found are about 9 Gyr old, a level which is set solely by the
photometric limits of our data. Even though this is less than the age of M4, we
discuss how these cooling WDs can eventually be used to check the turnoff ages
of globular clusters and hence constrain the age of the Universe.Comment: 46 pages, latex, no figures included, figures available at
ftp://ftp.astro.ubc.ca/pub/richer/wdfig.uu size 2.7Mb. To be published in the
Astrophysical Journa
Lightcurves of Type Ia Supernovae from Near the Time of Explosion
We present a set of 11 type Ia supernova (SN Ia) lightcurves with dense,
pre-maximum sampling. These supernovae (SNe), in galaxies behind the Large
Magellanic Cloud (LMC), were discovered by the SuperMACHO survey. The SNe span
a redshift range of z = 0.11 - 0.35. Our lightcurves contain some of the
earliest pre-maximum observations of SNe Ia to date. We also give a functional
model that describes the SN Ia lightcurve shape (in our VR-band). Our function
uses the "expanding fireball" model of Goldhaber et al. (1998) to describe the
rising lightcurve immediately after explosion but constrains it to smoothly
join the remainder of the lightcurve. We fit this model to a composite observed
VR-band lightcurve of three SNe between redshifts of 0.135 to 0.165. These SNe
have not been K-corrected or adjusted to account for reddening. In this
redshift range, the observed VR-band most closely matches the rest frame
V-band. Using the best fit to our functional description of the lightcurve, we
find the time between explosion and observed VR-band maximum to be
17.6+-1.3(stat)+-0.07(sys) rest-frame days for a SN Ia with a VR-band Delta
m_{-10} of 0.52mag. For the redshifts sampled, the observed VR-band
time-of-maximum brightness should be the same as the rest-frame V-band maximum
to within 1.1 rest-frame days.Comment: 35 pages, 18 figures, 15 tables; Higher quality PDF available at
http://ctiokw.ctio.noao.edu/~sm/sm/SNrise/index.html; AJ accepte
Supernova Cosmology and the ESSENCE project
The proper usage of Type Ia supernovae (SNe Ia) as distance indicators has
revolutionized cosmology, and added a new dominant component to the energy
density of the Universe, dark energy. Following the discovery and confirmation
era, the currently ongoing SNe Ia surveys aim to determine the properties of
the dark energy. ESSENCE is a five year ground-based supernova survey aimed at
finding and characterizing 200 SNe Ia in the redshift domain z=[0.2-0.8]. The
goal of the project is to put constraints on the equation of state parameter,
w, of the dark energy with an accuracy of <10%. This paper presents these
ongoing efforts in the context of the current developments in observational
cosmology.Comment: Submitted to EPS1
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