338 research outputs found
Non-native red alga Gracilaria vermiculophylla compensates for seagrass loss as blue crab nursery habitat in the emerging Chesapeake Bay ecosystem
Non-native species can become deleterious or potentially beneficial as components of novel ecosystems. The non-native red macroalga Gracilaria vermiculophylla may provide nursery habitat where eelgrass Zostera marina has been extirpated in Chesapeake Bay. A mensurative experiment was conducted monthly MayâOctober 2013 and 2014 in the York River, Chesapeake Bay, to evaluate hypotheses that Gracilaria (1) can compensate for the loss of seagrass nurseries by colonizing habitats where seagrass has been eliminated by environmental stress, and (2) is utilized by juvenile blue crabs (Callinectes sapidus) as nursery habitat. We quantified Gracilaria presence, percent cover, and biomass as a function of region (upriver, midriver, and downriver) and seagrass presence or absence using stratified random sampling, 20-m transects, and 0.0625-m2 quadrats. Gracilaria volume was measured and converted to dry weight. Effects of the factors and covariates temperature, salinity, dissolved oxygen, month, and year were analyzed using generalized linear models. Juvenile blue crab density was quantified in summer 2013 using suction sampling in Gracilaria and seagrass. A model with the collective effect of region and seagrass presence or absence (downriver seagrass, downriver unvegetated bottom, midriver unvegetated bottom) best predicted Gracilaria abundance. Gracilaria presence, percent cover, and biomass were highest in downriver seagrass, followed by downriver unvegetated bottom, and then midriver unvegetated bottom, where seagrass has been extirpated, supporting hypothesis (1). Gracilaria did not occur upriver, likely due to a lack of recruitment. Seagrass and Gracilaria housed similar densities of juvenile blue crabs, supporting hypothesis (2). We estimated that a single 40-ha cove system with Gracilaria could house 200,000 juvenile crabs as would a single 2.4-ha seagrass bed. Consequently, the numerous midriver and downriver cove systems in the York River could support millions of young juvenile blue crabs and thereby compensate for the loss of seagrass in the river and in other areas of Chesapeake Bay. At present, Gracilaria has no widespread negative impacts on seagrass in the York River or most regions of Chesapeake Bay, likely because percent cover and biomass are not excessively high at present. We posit that Gracilaria has become an important alternative nursery habitat for the blue crab in Chesapeake Bay and can potentially mitigate impacts of climate change on seagrass nursery habitats
The Shape of LITTLE THINGS Dwarf Galaxies DDO 46 and DDO 168: Understanding the stellar and gas kinematics
We present the stellar and gas kinematics of DDO 46 and DDO 168 from the
LITTLE THINGS survey and determine their respective Vmax/sigma_z,0 values. We
used the KPNO's 4-meter telescope with the Echelle spectrograph as a long-slit
spectrograph. We acquired spectra of DDO 168 along four position angles by
placing the slit over the morphological major and minor axes and two
intermediate position angles. However, due to poor weather conditions during
our observing run for DDO 46, we were able to extract only one useful data
point from the morphological major axis. We determined a central stellar
velocity dispersion perpendicular to the disk, sigma_z,0, of 13.5+/-8 km/s for
DDO 46 and of 10.7+/-2.9 km/s for DDO 168. We then derived the
maximum rotation speed in both galaxies using the LITTLE THINGS HI data. We
separated bulk motions from non-circular motions using a double Gaussian
decomposition technique and applied a tilted-ring model to the bulk velocity
field. We corrected the observed HI rotation speeds for asymmetric drift and
found a maximum velocity, Vmax, of 77.4 +/- 3.7 and 67.4 +/- 4.0 km/s for DDO
46 and DDO 168, respectively. Thus, we derived a kinematic measure,
Vmax/sigma_z,0, of 5.7 +/- 0.6 for DDO 46 and 6.3 +/- 0.3 for DDO 168.
Comparing these values to ones determined for spiral galaxies, we find that DDO
46 and DDO 168 have Vmax/sigma_z,0 values indicative of thin disks, which is in
contrast to minor-to-major axis ratio studies
Atomic Representations of Local and Global Chemistry in Complex Alloys
The exceptional properties observed in complex concentrated alloys (CCAs)
arise from the interplay between crystalline order and chemical disorder at the
atomic scale, complicating a unique determination of properties. In contrast to
conventional alloys, CCA properties emerge as distributions due to varying
local chemical environments and the specific scale of measurement. Currently
there are few ways to quantitatively define, track, and compare local alloy
compositions (versus a global label, i.e. equiatomic) contained in a CCA.
Molecular dynamics is used here to build descriptive metrics that connect a
global alloy composition to the diverse local alloy compositions that define
it. A machine-learned interatomic potential for MoNbTaTi is developed and we
use these metrics to investigate how property distributions change with
excursions in global-local composition space. Short-range order is examined
through the lens of local chemistry for the equiatomic composition,
demonstrating stark changes in vacancy formation energy with local chemistry
evolution.Comment: Version 2: editing and figure improvements, overall content
unchanged. 15 pages, 6 main figures, 1 supplemental figur
Large-scale assessment of 7-11-year-oldsâ cognitive and sensorimotor function within the Born in Bradford longitudinal birth cohort study
Background:Â Cognitive ability and sensorimotor function are crucial aspects of childrenâs development, and are associated with physical and mental health outcomes and educational attainment. This paper describes cross-sectional sensorimotor and cognitive function data collected on over 15,000 children aged 7-10 years, collected as part of the Born in Bradford (BiB) longitudinal birth-cohort study. Methodological details of the large-scale data collection process are described, along with initial analyses of the data involving the relationship between cognition/sensorimotor ability and age and task difficulty, and associations between tasks. Method: Data collection was completed in 86 schools between May 2016 and July 2019. Children were tested at school, individually, using a tablet computer with a digital stylus or finger touch for input. Assessments comprised a battery of three sensorimotor tasks (Tracking, Aiming, & Steering) and five cognitive tasks (three Working Memory tasks, Inhibition, and Processing Speed), which took approximately 40 minutes. Results: Performance improved with increasing age and decreasing task difficulty, for each task. Performance on all three sensorimotor tasks was correlated, as was performance on the three working memory tasks. In addition, performance on a composite working memory score correlated with performance on both inhibition and processing speed. Interestingly, within age-group variation was much larger than between age-group variation. Conclusions: The current project collected computerised measures of a range of cognitive and sensorimotor functions at 7-10 years of age in over 15,000 children. Performance varied as expected by age and task difficulty, and showed the predicted correlations between related tasks. Large within-age group variation highlights the need to consider the profile of individual children in studying cognitive and sensorimotor development. These data can be linked to the wider BiB dataset including measures of physical and mental health, biomarkers and genome-wide data, socio-demographic information, and routine data from local health and education services.</p
Comparative Performance of Three Length-Based Mortality Estimators
Lengthâbased methods provide alternatives for estimating the instantaneous total mortality rate (Z) in exploited marine populations when data are not available for ageâbased methods. We compared the performance of three equilibrium lengthâbased methods: the lengthâconverted catch curve (LCCC), the BevertonâHolt equation (BHE), and the lengthâbased spawning potential ratio (LBâSPR) method. The LCCC and BHE are two historically common procedures that use length as a proxy for age. From a truncated lengthâfrequency distribution of fully selected animals, the LCCC estimates Z with a regression of the logarithm of catch at length by the midpoint of the lengthâbins, while the BHE estimates Z as a function of the mean length. The LBâSPR method is a likelihoodâbased population dynamics model, whichâunlike the LCCC and BHEâdoes not require data truncation. Using Monte Carlo simulations across a range of scenarios with varying mortality and life history characteristics, our study showed that neither the LCCC nor the BHE was uniformly superior in terms of bias or root mean square error across simulations, but these estimators performed better than LBâSPR, which had the largest bias in most cases. Generally, if the ratio of natural mortality (M) to the von Bertalanffy growth rate parameter (K) is low, then the BHE is most preferred, although there is likely to be high bias and low precision. If M/K is high, then the LCCC and BHE performed better and similarly to each other. Differences in performance among commonly used truncation methods for the LCCC and BHE were small. The LBâSPR method did not perform as well as the classical methods but may still be of interest because it provides estimates of a logistic selectivity curve. The M/K ratio provided the most contrast in the performance of the three methods, suggesting that it should be considered for predicting the likely performance of lengthâbased mortality estimators
Minimal residual disease prior to allogeneic hematopoietic cell transplantation in acute myeloid leukemia: a meta-analysis
Minimal residual disease prior to allogeneic hematopoietic cell transplantation has been associated with increased risk of relapse and death in patients with acute myeloid leukemia, but detection methodologies and results vary widely. We performed a systematic review and meta-analysis evaluating the prognostic role of minimal residual disease detected by polymerase chain reaction or multiparametric flow cytometry before transplant. We identified 19 articles published between January 2005 and June 2016 and extracted hazard ratios for leukemia-free survival, overall survival, and cumulative incidences of relapse and non-relapse mortality. Pre-transplant minimal residual disease was associated with worse leukemia-free survival (HR=2.76 [1.90-4.00]), overall survival (HR=2.36 [1.73-3.22]), and cumulative incidence of relapse (HR=3.65 [2.53-5.27]), but not non-relapse mortality (HR=1.12 [0.81-1.55]). These associations held regardless of detection method, conditioning intensity, and patient age. Adverse cytogenetics was not an independent risk factor for death or relapse. There was more heterogeneity among studies using flow cytometry-based than WT1 polymerase chain reaction-based detection (I(2)=75.1% vs. <0.1% for leukemia-free survival, 67.8% vs. <0.1% for overall survival, and 22.1% vs. <0.1% for cumulative incidence of relapse). These results demonstrate a strong relationship between pre-transplant minimal residual disease and post-transplant relapse and survival. Outcome heterogeneity among studies using flow-based methods may underscore site-specific methodological differences or differences in test performance and interpretation
Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis
Vascular morphogenesis requires persistent endothelial cell motility that is responsive to diverse and dynamic mechanical stimuli. Here, we interrogated the mechanotransductive feedback dynamics that govern endothelial cell motility and vascular morphogenesis. We show that the transcriptional regulators, YAP and TAZ, are activated by mechanical cues to transcriptionally limit cytoskeletal and focal adhesion maturation, forming a conserved mechanotransductive feedback loop that mediates human endothelial cell motility in vitro and zebrafish intersegmental vessel (ISV) morphogenesis in vivo. This feedback loop closes in 4 hours, achieving cytoskeletal equilibrium in 8 hours. Feedback loop inhibition arrested endothelial cell migration in vitro and ISV morphogenesis in vivo. Inhibitor washout at 3 hrs, prior to feedback loop closure, restored vessel growth, but washout at 8 hours, longer than the feedback timescale, did not, establishing lower and upper bounds for feedback kinetics in vivo. Mechanistically, YAP and TAZ induced transcriptional suppression of myosin II activity to maintain dynamic cytoskeletal equilibria. Together, these data establish the mechanoresponsive dynamics of a transcriptional feedback loop necessary for persistent endothelial cell migration and vascular morphogenesis
Longitudinal data reveal strong genetic and weak non-genetic components of ethnicity-dependent blood DNA methylation levels
Epigenetic architecture is influenced by genetic and environmental factors, but little is known about their relative contributions or longitudinal dynamics. Here, we studied DNA methylation (DNAm) at over 750,000 CpG sites in mononuclear blood cells collected at birth and age 7 from 196 children of primarily self-reported Black and Hispanic ethnicities to study race-associated DNAm patterns. We developed a novel Bayesian method for high-dimensional longitudinal data and showed that race-associated DNAm patterns at birth and age 7 are nearly identical. Additionally, we estimated that up to 51% of all self-reported race-associated CpGs had race-dependent DNAm levels that were mediated through local genotype and, quite surprisingly, found that genetic factors explained an overwhelming majority of the variation in DNAm levels at other, previously identified, environmentally-associated CpGs. These results indicate that race-associated blood DNAm patterns in particular, and blood DNAm levels in general, are primarily driven by genetic factors, and are not as sensitive to environmental exposures as previously suggested, at least during the first 7 years of life
The Thermal Regulation of Gravitational Instabilities in Protoplanetary Disks III. Simulations with Radiative Cooling and Realistic Opacities
This paper presents a fully three-dimensional radiative hydrodymanics
simulation with realistic opacities for a gravitationally unstable 0.07 Msun
disk around a 0.5 Msun star. We address the following aspects of disk
evolution: the strength of gravitational instabilities under realistic cooling,
mass transport in the disk that arises from GIs, comparisons between the
gravitational and Reynolds stresses measured in the disk and those expected in
an alpha-disk, and comparisons between the SED derived for the disk and SEDs
derived from observationally determined parameters. The mass transport in this
disk is dominated by global modes, and the cooling times are too long to permit
fragmentation for all radii. Moreover, our results suggest a plausible
explanation for the FU Ori outburst phenomenon.Comment: 45 pages, 17 figures; submitted to Ap
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