Energy Loss of Leading Hadrons and Direct Photon production in Evolving Quark-Gluon Plasma

We calculate the nuclear modification factor of neutral pions and the photon yield at high p_T in central Au-Au collisions at RHIC (\sqrt{s}=200 GeV) and Pb-Pb collisions at the LHC (\sqrt{s}=5500 GeV). A leading-order accurate treatment of jet energy loss in the medium has been convolved with a physical description of the initial spatial distribution of jets and a (1+1) dimensional expansion. We reproduce the nuclear modification factor of pion R_{AA} at RHIC, assuming an initial temperature T_i=370 MeV and a formation time \tau_i=0.26 fm/c, corresponding to dN/dy=1260. The resulting suppression depends on the particle rapidity density dN/dy but weakly on the initial temperature. The jet energy loss treatment is also included in the calculation of high p_T photons. Photons coming from primordial hard N-N scattering are the dominant contribution at RHIC for p_T > 5 GeV, while at the LHC, the range 8<p_T<14 GeV is dominated by jet-photon conversion in the plasma.Comment: 21 pages, 16 figures. Discussions and references added. New figure includind photon dat

Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes

6 pages, 5 figures.-- PMID: 8046349 [PubMed].-- PMCID: PMC2191607.Cytotoxic T cells (CTL) recognize short peptide epitopes presented by class I glycoproteins encoded by the major histocompatibility complex (MHC). It is not yet known whether peptides containing posttranslationally modified amino acids can also be recognized by CTL. To address this issue, we have studied the immunogenicity and recognition of a glycopeptide carrying an O-linked N-acetylglucosamine (GlcNAc) monosaccharide-substituted serine residue. This posttranslational modification is catalyzed by a recently described cytosolic glycosyltransferase. We show that glycosylation does not affect peptide binding to MHC class I and that glycopeptides can elicit a strong CTL response that is glycopeptide specific. Furthermore, glycopeptide recognition by cytotoxic T cells is dependent on the chemical structure of the glycan as well as its position within the peptide.We wish to thank Dr. Elena Sadovnikova and Dr. Hans J. Stanss (Imperial Cancer Research Foundation, London, UK) for their valuable help with raising antipeptide CTLs; and Professor Jens Chr. Jensenius (University of Aarbus, Denmark) for helpful discussions. J. S. Haurum is a Carlsberg-Wellcome Travelling Research Fellow, G. Asequell is an EC Fellow, and A. C. Lellouch is supported by a United States Public Health Service National Research Service Award F32 GM- 15811. This work was supported by the Carlsberg Foundation, the Wellcome trust, the Beckett Foundation, and Statens Sundhedsvidenskabelige Forskningsr~d, Denmark.Peer reviewe

Can luminous Lyman alpha emitters at zz ≃\simeq 5.7 and zz ≃\simeq 6.6 suppress star formation?

Addressing how strong UV radiation affects galaxy formation is central to understanding their evolution. The quenching of star formation via strong UV radiation (from starbursts or AGN) has been proposed in various scenes to solve certain astrophysical problems. Around luminous sources, some evidence of decreased star formation has been found but is limited to a handful of individual cases. No direct, conclusive evidence on the actual role of strong UV radiation in quenching star formation has been found. Here we present statistical evidence of decreased number density of faint (AB magnitude $\geq$ 24.75 mag) Ly\alpha emitters (LAEs) around bright (AB magnitude < 24.75 mag) LAEs even when the radius goes up to 10 pMpc for $z$ $\simeq$ 5.7 LAEs. A similar trend is found for z $\simeq$ 6.6 LAEs but only within 1 pMpc radius from the bright LAEs. We use a large sample of 1077 (962) LAEs at $z$ $\simeq$ 5.7 ($z$ $\simeq$ 6.6) selected in total areas of 14 (21) deg$^2$ with Subaru/Hyper Suprime-Cam narrow-band data, and thus, the result is of statistical significance for the first time at these high redshift ranges. A simple analytical calculation indicates that the radiation from the central LAE is not enough to suppress LAEs with AB mag $\geq$ 24.75 mag around them, suggesting additional physical mechanisms we are unaware of are at work. Our results clearly show that the environment is at work for the galaxy formation at $z$ $\sim$ 6 in the Universe.Comment: Accepted for publication at MNRA

Photon production in relativistic nuclear collisions at SPS and RHIC energies

Chiral Lagrangians are used to compute the production rate of photons from the hadronic phase of relativistic nuclear collisions. Special attention is paid to the role of the pseudovector a_1 meson. Calculations that include reactions with strange mesons, hadronic form factors and vector spectral densities consistent with dilepton production, as well as the emission from a quark-gluon plasma and primordial nucleon-nucleon collisions, reproduce the photon spectra measured at the Super Proton Synchrotron (SPS). Predictions for the Relativistic Heavy Ion Collider (RHIC) are made.Comment: Work presented at the 26th annual Montreal-Rochester-Syracuse-Toronto conference (MRST 2004) on high energy physics, Montreal, QC, Canada, 12-14 May 2004. 8 pages, 3 figure

Networking - A Statistical Physics Perspective

Efficient networking has a substantial economic and societal impact in a broad range of areas including transportation systems, wired and wireless communications and a range of Internet applications. As transportation and communication networks become increasingly more complex, the ever increasing demand for congestion control, higher traffic capacity, quality of service, robustness and reduced energy consumption require new tools and methods to meet these conflicting requirements. The new methodology should serve for gaining better understanding of the properties of networking systems at the macroscopic level, as well as for the development of new principled optimization and management algorithms at the microscopic level. Methods of statistical physics seem best placed to provide new approaches as they have been developed specifically to deal with non-linear large scale systems. This paper aims at presenting an overview of tools and methods that have been developed within the statistical physics community and that can be readily applied to address the emerging problems in networking. These include diffusion processes, methods from disordered systems and polymer physics, probabilistic inference, which have direct relevance to network routing, file and frequency distribution, the exploration of network structures and vulnerability, and various other practical networking applications.Comment: (Review article) 71 pages, 14 figure

Effect of real-time computer-aided polyp detection system (ENDO-AID) on adenoma detection in endoscopists-in-training: a randomized trial

Background The effect of computer-aided polyp detection (CADe) on adenoma detection rate (ADR) among endoscopists-in-training remains unknown. Methods We performed a single-blind, parallel-group, randomized controlled trial in Hong Kong between April 2021 and July 2022 (NCT04838951). Eligible subjects undergoing screening/surveillance/diagnostic colonoscopies were randomized 1:1 to receive colonoscopies with CADe (ENDO-AID(OIP-1), Olympus Co., Japan) or not (control) during withdrawal. Procedures were performed by endoscopists-in-training with <500 procedures and <3 years’ experience. Randomization was stratified by patient age, sex, and endoscopist experience (beginner vs intermediate-level, <200 vs 200-500 procedures). Image enhancement and distal attachment devices were disallowed. Subjects with incomplete colonoscopies or inadequate bowel preparation were excluded. Treatment allocation was blinded to outcome assessors. The primary outcome was ADR. Secondary outcomes were ADR for different adenoma sizes and locations, mean number of adenomas, and non-neoplastic resection rate. Results 386 and 380 subjects were randomized to CADe and control groups, respectively. The overall ADR was significantly higher in CADe than control group (57.5% vs 44.5%, adjusted relative risk 1.41, 95%CI 1.17-1.72, p<0.001). The ADRs for <5mm (40.4% vs 25.0%) and 5-10mm adenomas (36.8% vs 29.2%) were higher in CADe group. The ADRs were higher in CADe group in both right (42.0% vs 30.8%) and left colon (34.5% vs 27.6%), but there was no significant difference in advanced ADR. The ADRs were higher in CADe group among beginners (60.0% vs 41.9%) and intermediate-level endoscopists (56.5% vs 45.5%). Mean number of adenomas (1.48 vs 0.86) and non-neoplastic resection rate were higher in CADe group (52.1% vs 35.0%). Conclusions Among endoscopists-in-training, the use of CADe during colonoscopies was associated with increased overall ADR. (ClinicalTrials.gov: NCT04838951

Infrared Nonlinear Optics

Contains reports on six research projects.Defense Advanced Research Projects Agency Universities Research Initiative (Contract N00014-46-K-0760)Strategic Defense Initiative/Innovative Science & Technology, managed by the U.S. Naval Research Laboratory (Contract N00014-87-K-2031)National Science Foundation (Grant EET-87-18417

A Dyson Sphere around a black hole

The search for extraterrestrial intelligence (SETI) has been conducted for nearly 60 years. A Dyson Sphere, a spherical structure that surrounds a star and transports its radiative energy outward as an energy source for an advanced civilisation, is one of the main targets of SETI. In this study, we discuss whether building a Dyson Sphere around a black hole is effective. We consider six energy sources: (i) the cosmic microwave background, (ii) the Hawking radiation, (iii) an accretion disk, (iv) Bondi accretion, (v) a corona, and (vi) relativistic jets. To develop future civilisations (for example, a Type II civilisation), $4\times10^{26}\,{\rm W}$($1\,{\rm L_{\odot}}$) is expected to be needed. Among (iii) to (vi), the largest luminosity can be collected from an accretion disk, reaching $10^{5}\,{\rm L_{\odot}}$, enough to maintain a Type II civilisation. Moreover, if a Dyson Sphere collects not only the electromagnetic radiation but also other types of energy (e.g., kinetic energy) from the jets, the total collected energy would be approximately 5 times larger. Considering the emission from a Dyson Sphere, our results show that the Dyson Sphere around a stellar-mass black hole in the Milky Way ($10\,\rm kpc$ away from us) is detectable in the ultraviolet$(\rm 10-400\,{\rm nm)}$, optical$(\rm 400-760\,{\rm nm)}$, near-infrared($\rm 760\,{\rm nm}-5\,{\rm \mu m}$), and mid-infrared($\rm 5-40\,{\rm \mu m}$) wavelengths via the waste heat radiation using current telescopes such as Galaxy Evolution Explorer Ultraviolet Sky Surveys. Performing model fitting to observed spectral energy distributions and measuring the variability of radial velocity may help us to identify these possible artificial structures.Comment: This paper has been accepted for publication in MNRA

Future landscapes: managing within complexity

A regional landscape is a complex social–ecological system comprising a dynamic mosaic of land uses. Management at this scale requires an understanding of the myriad interacting human and natural processes operating on the landscape over a continuum of spatial and temporal scales.Complexity science, which is not part of traditional management approaches, provides a valuable conceptual framework and quantitative tools for dealing with cross-scale interactions and non-linear dynamics in social–ecological systems. Here, we identify concepts and actions arising from complexity science that can be learned and applied by ecosystem managers and discuss how they might be implemented to achieve sustainable future landscapes.Lael Parrott and Wayne S Meye

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease

Changes in the levels of circulating proteins are associated with Alzheimer’s disease (AD), whereas their pathogenic roles in AD are unclear. Here, we identified soluble ST2 (sST2), a decoy receptor of interleukin-33–ST2 signaling, as a new disease-causing factor in AD. Increased circulating sST2 level is associated with more severe pathological changes in female individuals with AD. Genome-wide association analysis and CRISPR–Cas9 genome editing identified rs1921622, a genetic variant in an enhancer element of IL1RL1, which downregulates gene and protein levels of sST2. Mendelian randomization analysis using genetic variants, including rs1921622, demonstrated that decreased sST2 levels lower AD risk and related endophenotypes in females carrying the Apolipoprotein E (APOE)-ε4 genotype; the association is stronger in Chinese than in European-descent populations. Human and mouse transcriptome and immunohistochemical studies showed that rs1921622/sST2 regulates amyloid-beta (Aβ) pathology through the modulation of microglial activation and Aβ clearance. These findings demonstrate how sST2 level is modulated by a genetic variation and plays a disease-causing role in females with AD