Frontotemporal dementia: the impact of patient behavioral symptoms on the physical and mental health of family caregivers.

BackgroundProviding informal support to someone with frontotemporal dementia (FTD) could be very stressful. Clarifying the relationship between patient behavioral problems and caregiver health could spur future research on effective symptom management strategies.MethodsSixty-one FTD family caregivers participated in a postal survey.ResultsPatient symptom severity was negatively associated with caregiver mental health (r = -0.26, p < 0.05) but not significantly associated with caregiver physical health. In a regression analysis, caregiver emotional distress from patient behaviors made a statistically significant contribution to caregiver mental health, explaining approximately 10% of its variance.ConclusionThis study underscores the importance of focusing on FTD caregivers' perceived emotional distress from patient behavioral problems and ensuring they are getting the appropriate support they need

Assessment of fatigue in patients with COPD participating in a pulmonary rehabilitation program : a feasibility study

Fatigue is a distressing, complex, and multidimensional sensation, that is common in individuals with chronic obstructive pulmonary disease (COPD), and impacts negatively on their functioning and quality of life. Limited research has been conducted to examine how various factors may influence the different dimensions of subjective fatigue experienced in these individuals. Four dimensions of subjective fatigue including: emotional, behavioural, cognitive, and physical, were examined in a convenience sample of 42 participants with COPD who attended an outpatient pulmonary rehabilitation program. The primary purpose of this feasibility study was to determine the proportion of individuals experiencing the four dimensions of fatigue, and to examine the relationships between these dimensions of fatigue and various influencing factors (dyspnea, depression, anxiety, sleep quality, activity limitation, heart rate, and oxygen saturation). The secondary purpose was to compare the four dimensions of fatigue by sex, supplemental oxygen use, smoking status, and severity of dyspnea, and to examine the relationships between the four dimensions of fatigue and age, the number of co-morbidities, and the amount of pulmonary rehabilitation received. Self-report questionnaires were used to measure fatigue (Multidimensional Fatigue Inventory – MFI), anxiety and depression (Hospital Anxiety and Depression Scale – HADS), and sleep quality (Pittsburgh Sleep Quality Index – PSQI). Pulmonary rehabilitation health records were accessed to collect data on the remaining variables. The majority of the participants (61.9% - 81.0%) experienced moderate levels of subjective fatigue in all four dimensions. Moderate to severe levels of physical fatigue were experienced in 95.3% of the participants. The only significant relationship was between anxiety and emotional fatigue; all other relationships were statistically insignificant. There were no significant differences between sex, supplemental oxygen use, smoking status, and severity of dyspnea on the four dimensions of subjective fatigue. Many of the participants had probable presence of clinical anxiety (42.9%), where the prevalence of anxiety was nearly twice as high as depression (21.4%). Findings from this study can be used by healthcare professionals to gain a better understanding of fatigue in individuals with COPD who attend pulmonary rehabilitation, and help in developing effective interventions for reducing the distressing effects of fatigue

Teaching and Learning Primary Science for Marginalised Children

In the twenty-first century, the demand for large scale human capital workforce based on scientific knowledge is rising especially in Science, Technology, Engineering and Mathematics (STEM)-related carriers. Innovative societies need people who are equipped with scientific knowledge and competencies. But, science education has tended to be perceived as irrelevant and not interested by marginalised children. Therefore, this study aimed to determine the impact of the learning outside the classroom (LOC) module on academic achievement and intrinsic motivation of marginalised learners in learning science. For that, quasi-experimental design with pre-test post-test, non-equivalent control group research design was implemented. The treatment group (n = 38) used LOC module, while the control group (n = 35) used conventional module in teaching science. Academic achievement evaluates using Science Achievement Test (SAT), whereas intrinsic motivation evaluates using Intrinsic Motivation Questionnaire (IMQ). Data obtained from AT and IMQ were analysed using independent-sample T-test and MANOVA repeated measures. The results showed non-significant increase in SAT mean scores in the treatment group. The findings also indicate that there is no significant main effect and interaction effect between group and time towards intrinsic motivation. As a result, the two teaching methods do not have significant and positive impact on intrinsic motivation among marginalised learners

Connexins in leukocytes: shuttling messages?

Gap junctions, formed by the connexin (Cx) protein family, are intercellular channels that permit the cytoplasmic exchange of ions and small metabolites between neighboring cells, a process called gap junction intercellular communication (GJIC). These channels possess unique properties, including distinctive permeabilities for various signaling molecules, which depend on the connexin member(s) that form them. Importantly, GJIC must be properly controlled as its misregulation might contribute to diseases. Morphological and functional studies have revealed ‘gap junction-like' structures and cell-to-cell communication involving cells of the immune system. The connexins involved in such contacts have been partially identified in recent years. This review focuses on the potential physiological roles of gap junctions in the development and recruitment of leukocytes as well as in the regulation of the immune response. Furthermore, the importance of GJIC in immuno-inflammatory pathologies is illustrated in atherosclerosi

Fatigue in patients with COPD participating in a pulmonary rehabilitation program

Cindy J Wong1, Donna Goodridge1, Darcy D Marciniuk2, Donna Rennie1,31College of Nursing, 2College of Medicine, 3Canadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, CanadaBackground: Fatigue is a distressing, complex, multidimensional sensation common in individuals with chronic obstructive pulmonary disease (COPD). While fatigue negatively impacts functional performance and quality of life, there has been little study of the fatigue that affects participants in pulmonary rehabilitation programs. The purpose of this study was to examine the emotional, behavioral, cognitive, and physical dimensions of fatigue and their relationships to dyspnea, mental health, sleep, and physiologic factors.Patients and methods: A convenience sample of 42 pulmonary rehabilitation participants with COPD completed self-report questionnaires which measured dimensions of fatigue using the Multidimensional Fatigue Inventory, anxiety and depression using the Hospital Anxiety and Depression Scale, and sleep quality using the Pittsburgh Sleep Quality Index. Data on other clinical variables were abstracted from pulmonary rehabilitation program health records.Results: Almost all (95.3%) participants experienced high levels of physical fatigue. High levels of fatigue were also reported for the dimensions of reduced activity (88.1%), reduced motivation (83.3%), mental fatigue (69.9%), and general fatigue (54.5%). Close to half (42.9%) of participants reported symptoms of anxiety, while almost one quarter (21.4%) reported depressive symptoms. Age was related to the fatigue dimensions of reduced activity (ρ = 0.43, P < 0.01) and reduced motivation (ρ = 0.31, P < 0.05). Anxiety was related to reduced motivation (ρ = -0.47, P < 0.01). Fatigue was not associated with symptoms of depression, sleep quality, gender, supplemental oxygen use, smoking status, or Medical Research Council dyspnea scores.Conclusions: Fatigue (particularly the physical and reduced motivation dimensions of fatigue) was experienced by almost all participants with COPD attending this pulmonary rehabilitation program. Fatigue affected greater proportions of participants than either anxiety or depression. The high prevalence of fatigue may impact on enrolment, participation, and attrition in pulmonary rehabilitation programs. Further investigation of the nature, correlates, and impact of fatigue in this population is required.Keywords: COPD, fatigue, pulmonary rehabilitation, anxiety, depression, sleep qualit

A study of the reasons and functions of non-suicidal self-injury (NSSI) among students in Hong Kong and United Kingdom

This study examines non-suicidal self-injury (NSSI) in a community sample of adolescents and young adults in Hong Kong and United Kingdom. Non-suicidal self‐injury (NSSI) refers to direct, deliberate destruction of one’s own body tissue in the absence of intent to die. Apart from investigating the reasons and functions of non-suicidal self‐injury (NSSI), this study also examined the gender as well as cultural differences in self‐injurious behaviors. Functional Assessment of Self‐Mutilation (FASM) was used to examine non‐suicidal self-injury (NSSI). Overall, 17.1% (n=46) out of 269 participants (n=269) endorsed engaging in non-suicidal self‐injury (NSSI) in the past 12 months, with more females (9.7%) than males (7.1%). 18.2% (n = 49) of participants reported engagement in non-suicidal self‐injury (NSSI) at least once in their life time. Stresses and borderline personality disorders (BPD) were found to correlate with self‐harm behaviors. No cultural differences in self‐harm behaviors between Hong Kong and United Kingdom were shown. Meanwhile, no gender differences were shown in the types of self‐harm behaviors engaged and the reasons of engaging in non-suicidal self-injury (NSSI)