Determination of the Defining Boundary in Nuclear Magnetic Resonance Diffusion Experiments

While nuclear magnetic resonance diffusion experiments are widely used to resolve structures confining the diffusion process, it has been elusive whether they can exactly reveal these structures. This question is closely related to X-ray scattering and to Kac's "hear the drum" problem. Although the shape of the drum is not "hearable", we show that the confining boundary of closed pores can indeed be detected using modified Stejskal-Tanner magnetic field gradients that preserve the phase information and enable imaging of the average pore in a porous medium with a largely increased signal-to-noise ratio.Comment: 13 pages, 2 figure

Theranostic cRGD-BioShuttle Constructs Containing Temozolomide- and Cy7 For NIR-Imaging and Therapy

Innovative and personalized therapeutic approaches result from the identification and control of individual aberrantly expressed genes at the transcriptional and post-transcriptional level. Therefore, it is of high interest to establish diagnostic, therapeutic and theranostic strategies at these levels. In the present study, we used the Diels-Alder Reaction with inverse electron demand (DARinv) click chemistry to prepare a series of cyclic RGD-BioShuttle constructs. These constructs carry the near-infrared (NIR) imaging agent Cy7 and the chemotherapeutic agent temozolomide (TMZ). We evaluated their uptake by and their efficacy against integrin αvβ3-expressing MCF7 human breast carcinoma cells. In addition, using a mouse phantom, we analyzed the suitability of this targeted theranostic agent for NIR optical imaging. We observed that the cyclic RGD-based carriers containing TMZ and/or Cy7 were effectively taken up by αvβ3-expressing cells, that they were more effective than free TMZ in inducing cell death, and that they could be quantitatively visualized using NIR fluorescence imaging. Therefore, these targeted theranostic agents are considered to be highly suitable systems for improving disease diagnosis and therapy

applying time dependent data for fluorescence tomography

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Патриотическое воспитание молодежи на примере малой Родины

В статье поднята важнейшая тема - патриотическое воспитание подрастающего поколения России. Этот вопрос особенно актуален сейчас, учитывая то, что в современном обществе произошла переоценка значимости жизненных ценностей: материальное благополучие стало основным, духовно-нравственное стало вторичным. Авторы анализируют сложившуюся ситуацию, приводят успешные примеры работы с молодежью на примере Юргинского района. В статье даны рекомендации по возрождению патриотического воспитания, как на местном уровне, так и на уровне государства

Молодежь и современные информационные технологии: сборник трудов XVI Международной научно-практической конференции студентов, аспирантов и молодых учёных, 3-7 декабря 2018 г., г. Томск

Сборник содержит доклады, представленные на XVI Международной научно-практической конференции студентов, аспирантов и молодых ученых «Молодежь и современные информационные технологии», прошедшей в Томском политехническом университете на базе Инженерной школы информационных технологий и робототехники. Материалы сборника отражают доклады студентов, аспирантов и молодых ученых, принятые к обсуждению на секциях: «Компьютерное моделирование и интеллектуальный анализ данных», «Автоматизация и управление в технических системах», «Робототехнические и мехатронные системы», «Цифровизация, IT и цифровая экономика», «Компьютерная графика и дизайн». Сборник предназначен для специалистов в области информационных технологий, студентов и аспирантов соответствующих специальностей

Tracking of an interventional catheter with a ferromagnetic tip using dual-echo projections

Interventional devices with ferromagnetic components can be manipulated remotely using forces induced by the MRI gradients. To deflect the tip of an endovascular catheter, large ferromagnetic spheres of 2 mm diameter are required to exert sufficiently high magnetic forces; however, tracking of these devices is difficult due to the large image artifacts. In this study, a new dual-echo technique is proposed to improve the stability of localizing and tracking medical devices with ferromagnetic components. MR tracking methods with selective off-resonant excitation and phase compensation with a rephasing gradient can detect ferromagnetic spheres up to a diameter of 1 mm only. In this work, a dual-echo technique is used with two rephasing gradients to stabilize the off-set localization. With rephasing being applied in orthogonal directions, an SNR of 5 was achieved in the signal projections. Compared to a single-echo acquisition the dual-echo method reduces the position error in a phantom from 8 mm to 1.6 mm. In an in vivo study a tracking precision of 4 mm was measured without steering gradients at an image update rate of 2 images per second. Steering experiments were successfully performed with a prototype catheter with ferromagnetic sphere in an aorta phantom and in the vena cava of a pig