Separating the Effects of Hemodialysis Dose and Nutrition: In Search of the Optimal Dialysis Dose

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73859/1/j.1525-139X.1999.90218.x.pd

How Will the Results of the HEMO Study Impact Dialysis Practice?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71984/1/j.1525-139X.2003.03003_3.x.pd

Trends in Organ Donation and Transplantation in the United States, 1999–2008

Received 30 September 2009, revised 14 December 2009 and accepted for publication 18 December 2009Note on sources: The articles in this report are based on the reference tables in the 2009 OPTN/SRTR Annual Report . Table numbers are noted in brackets and may be found online at: http://ustransplant.org .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79137/1/j.1600-6143.2010.03021.x.pd

Parameterized Littlewood-Paley operators with variable kernels on Hardy spaces and weak Hardy spaces

In this paper, by using the atomic decomposition theory of Hardy space and weak Hardy space, we discuss the boundedness of parameterized Littlewood-Paley operator with variable kernel on these spaces.Comment: 15 pages. arXiv admin note: text overlap with arXiv:1711.0961

Recent Trends and Results for Organ Donation and Transplantation in the United States, 2005

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72853/1/j.1600-6143.2006.01268.x.pd

A Sequential Stratification Method for Estimating the Effect of a Time-Dependent Experimental Treatment in Observational Studies

Survival analysis is often used to compare experimental and conventional treatments. In observational studies, the therapy may change during follow-up and such crossovers can be summarized by time-dependent covariates. Given the ever-increasing donor organ shortage, higher-risk kidneys from expanded criterion donors (ECD) are being transplanted. Transplant candidates can choose whether to accept an ECD organ (experimental therapy), or to remain on dialysis and wait for a possible non-ECD transplant later (conventional therapy). A three-group time-dependent analysis of such data involves estimating parameters corresponding to two time-dependent indicator covariates representing ECD transplant and non-ECD transplant, each compared to remaining on dialysis on the waitlist. However, the ECD hazard ratio estimated by this time-dependent analysis fails to account for the fact that patients who forego an ECD transplant are not destined to remain on dialysis forever, but could subsequently receive a non-ECD transplant. We propose a novel method of estimating the survival benefit of ECD transplantation relative to conventional therapy (waitlist with possible subsequent non-ECD transplant). Compared to the time-dependent analysis, the proposed method more accurately characterizes the data structure and yields a more direct estimate of the relative outcome with an ECD transplant.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66010/1/j.1541-0420.2006.00527.x.pd

Effects of age, sex, and anthropometric factors on nerve conduction measures

Associations among measures of median, ulnar, and sural nerve conduction and age, skin temperature, sex, and anthropometric factors were evaluated in a population of 105 healthy, asymptomatic adults without occupational exposure to highly repetitive or forceful hand exertions. Height was negatively associated with sensory amplitude in all nerves tested ( P < 0.001), and positively associated with median and ulnar sensory distal latencies ( P < 0.01) and sural latency ( P < 0.001). Index finger circumference was negatively associated with median and ulnar sensory amplitudes ( P < 0.05). Sex, in isolation from highly correlated anthropometric factors such as height, was not found to be a significant predictor of median or ulnar nerve conduction measures. Equations using age, height, and finger circumference for prediction of normal values are presented. Failure to adjust normal nerve conduction values for these factors decreases the diagnostic specificity and sensitivity of the described measures, and may result in misclassification of individuals. © 1992 John Wiley & Sons, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50152/1/880151007_ftp.pd

Influence of Graft Type on Outcomes After Pediatric Liver Transplantation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74904/1/j.1600-6143.2004.00359.x.pd

Systematic Evaluation of Pancreas Allograft Quality, Outcomes and Geographic Variation in Utilization

Pancreas allograft acceptance is markedly more selective than other solid organs. The number of pancreata recovered is insufficient to meet the demand for pancreas transplants (PTx), particularly for patients awaiting simultaneous kidney-pancreas (SPK) transplant. Development of a pancreas donor risk index (PDRI) to identify factors associated with an increased risk of allograft failure in the context of SPK, pancreas after kidney (PAK) or pancreas transplant alone (PTA), and to assess variation in allograft utilization by geography and center volume was undertaken. Retrospective analysis of all PTx performed from 2000 to 2006 (n = 9401) was performed using Cox regression controlling for donor and recipient characteristics. Ten donor variables and one transplant factor (ischemia time) were subsequently combined into the PDRI. Increased PDRI was associated with a significant, graded reduction in 1-year pancreas graft survival. Recipients of PTAs or PAKs whose organs came from donors with an elevated PDRI (1.57–2.11) experienced a lower rate of 1-year graft survival (77%) compared with SPK transplant recipients (88%). Pancreas allograft acceptance varied significantly by region particularly for PAK/PTA transplants (p < 0.0001). This analysis demonstrates the potential value of the PDRI to inform organ acceptance and potentially improve the utilization of higher risk organs in appropriate clinical settings.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78607/1/j.1600-6143.2009.02996.x.pd