7 research outputs found

    Cost-Effective Seismic Exploration: 2D Reflection Imaging at the Kylylahti Massive Sulfide Deposit, Finland

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    We show that by using an advanced pre-stack depth imaging algorithm it is possible to retrieve meaningful and robust seismic images with sparse shot points, using only 3–4 source points per kilometer along a seismic profile. Our results encourage the use of 2D seismic reflection profiling as a reconnaissance tool for mineral exploration in areas with limited access for active seismic surveys. We used the seismic data acquired within the COGITO-MIN project comprising two approximately 6 km long seismic reflection profiles at the polymetallic Kylylahti massive sulfide mine site in eastern Finland. The 2D seismic data acquisition utilized both Vibroseis and dynamite sources with 20 m spacing and wireless receivers spaced every 10 m. For both source types, the recorded data show clear first breaks over all offsets and reflectors in the raw shot gathers. The Kylylahti area is characterized by folded and faulted, steeply dipping geological contacts and structures. We discuss post-stack and pre-stack data processing and compare time and depth imaging techniques in this geologically complex Precambrian hardrock area. The seismic reflection profiles show prominent reflectors at 4.5–8 km depth utilizing different migration routines. In the shallow subsurface, steep reflectors are imaged, and within and underneath the known Kylylahti ultramafic body reflectivity is prominent but discontinuous

    Cost-Effective Seismic Exploration: 2D Reflection Imaging at the Kylylahti Massive Sulfide Deposit, Finland

    Get PDF
    We show that by using an advanced pre-stack depth imaging algorithm it is possible to retrieve meaningful and robust seismic images with sparse shot points, using only 3–4 source points per kilometer along a seismic profile. Our results encourage the use of 2D seismic reflection profiling as a reconnaissance tool for mineral exploration in areas with limited access for active seismic surveys. We used the seismic data acquired within the COGITO-MIN project comprising two approximately 6 km long seismic reflection profiles at the polymetallic Kylylahti massive sulfide mine site in eastern Finland. The 2D seismic data acquisition utilized both Vibroseis and dynamite sources with 20 m spacing and wireless receivers spaced every 10 m. For both source types, the recorded data show clear first breaks over all offsets and reflectors in the raw shot gathers. The Kylylahti area is characterized by folded and faulted, steeply dipping geological contacts and structures. We discuss post-stack and pre-stack data processing and compare time and depth imaging techniques in this geologically complex Precambrian hardrock area. The seismic reflection profiles show prominent reflectors at 4.5–8 km depth utilizing different migration routines. In the shallow subsurface, steep reflectors are imaged, and within and underneath the known Kylylahti ultramafic body reflectivity is prominent but discontinuous

    Cost-effective seismic exploration: 2D reflection imaging at the Kylylahti massive sulfide deposit, Finland

    Get PDF
    We show that by using an advanced pre-stack depth imaging algorithm it is possible to retrieve meaningful and robust seismic images with sparse shot points, using only 3-4 source points per kilometer along a seismic profile. Our results encourage the use of 2D seismic reflection profiling as a reconnaissance tool for mineral exploration in areas with limited access for active seismic surveys. We used the seismic data acquired within the COGITO-MIN project comprising two approximately 6 km long seismic reflection profiles at the polymetallic Kylylahti massive sulfide mine site in eastern Finland. The 2D seismic data acquisition utilized both Vibroseis and dynamite sources with 20 m spacing and wireless receivers spaced every 10 m. For both source types, the recorded data show clear first breaks over all offsets and reflectors in the raw shot gathers. The Kylylahti area is characterized by folded and faulted, steeply dipping geological contacts and structures. We discuss post-stack and pre-stack data processing and compare time and depth imaging techniques in this geologically complex Precambrian hardrock area. The seismic reflection profiles show prominent reflectors at 4.5-8 km depth utilizing different migration routines. In the shallow subsurface, steep reflectors are imaged, and within and underneath the known Kylylahti ultramafic body reflectivity is prominent but discontinuous.Peer reviewe

    Mutation, drift and selection in single-driver hematologic malignancy: Example of secondary myelodysplastic syndrome following treatment of inherited neutropenia.

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    Cancer development is driven by series of events involving mutations, which may become fixed in a tumor via genetic drift and selection. This process usually includes a limited number of driver (advantageous) mutations and a greater number of passenger (neutral or mildly deleterious) mutations. We focus on a real-world leukemia model evolving on the background of a germline mutation. Severe congenital neutropenia (SCN) evolves to secondary myelodysplastic syndrome (sMDS) and/or secondary acute myeloid leukemia (sAML) in 30-40%. The majority of SCN cases are due to a germline ELANE mutation. Acquired mutations in CSF3R occur in >70% sMDS/sAML associated with SCN. Hypotheses underlying our model are: an ELANE mutation causes SCN; CSF3R mutations occur spontaneously at a low rate; in fetal life, hematopoietic stem and progenitor cells expands quickly, resulting in a high probability of several tens to several hundreds of cells with CSF3R truncation mutations; therapeutic granulocyte colony-stimulating factor (G-CSF) administration early in life exerts a strong selective pressure, providing mutants with a growth advantage. Applying population genetics theory, we propose a novel two-phase model of disease development from SCN to sMDS. In Phase 1, hematopoietic tissues expand and produce tens to hundreds of stem cells with the CSF3R truncation mutation. Phase 2 occurs postnatally through adult stages with bone marrow production of granulocyte precursors and positive selection of mutants due to chronic G-CSF therapy to reverse the severe neutropenia. We predict the existence of the pool of cells with the mutated truncated receptor before G-CSF treatment begins. The model does not require increase in mutation rate under G-CSF treatment and agrees with age distribution of sMDS onset and clinical sequencing data
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