Regulierung der Krautfäule(Phytophthora infestans) mit reduzierten Kupfer-Aufwandmengen im Kartoffelanbau

Four field experiments were conducted in 2004 to analyse the efficacy of reduced rates of copper fungicides against Phytophthora infestans (3 x organic and 1 x conventional growing). Copper (Cu-hydroxide, Cu-oxychloride or Cu-octanoate) was sprayed in a weekly routine or according to the decision support system SIMPHYT with total dosages ranging from 0.57 kg/ha to 4.0 kg/ha. The results revealed in almost all treatments a significant reduction of late blight, except for the lowest rates (e.g. 4 x 0.14 kg/ha Cu as Cu-octanoate or 6 x 0.15 kg/ha Cu as Cu-hydroxide). There was a clear dose-response relation between increasing rates of copper and control of late blight in each experiment. Marketable yields varied from 132 dt/ha to 238 dt/ha in organic field trials depending on trial site and copper treatment. Generally, an effect of copper treatment and late blight on yield could be shown. Even a slight reduction of P. infestans increased yield by 10 % to 20 %. The influence of copper dosage on late blight was more obvious than influence of copper spraying on yield. A dropleg spraying system (copper application within the crop canopy) which was tested on one trial site did not improve blight control compared to conventional application

A slow and dark atomic beam

We demonstrate a method to produce a very slow atomic beam from a vapour cell magneto-optical trap. Atoms are extracted from the trap using the radiation pressure imbalance caused by a push beam. An additional transfer beam placed near the center of the trap transfers the atomic beam into an off-resonant state. The velocity of the atomic beam has been varied by changing the intensity of the push beam or the position of the transfer beam. The method can be used to generate a continuous, magnetically guided atomic beam in a dark state.Comment: 14 page

Kupferminimierungsstrategien im ökologischen Kartoffelanbau – Projekt “ÖKO-SIMPHYT“: Erste Erfahrungen aus dem norddeutschen Freiland

In the research project „ÖKO-SIMPHYT“ different strategies are tested to reduce the copper application for Phytophthora infestans in organic potato cultivation. Within the first two years of our research a reduction of the total amount of copper per hectare could be accomplished when applying the new developed forecast system ÖKO-SIMPHYT. With this decision support system a reduction of copper up to 46% was possible, when the infection pressure was relatively low. These first results have now to be proven under high infection pressure conditions. Experiments were carried out in the greenhouse to test the rain stability of copper and contacting agents. It could be proved that precipitation of 30 mm is able to reduce the degree of a copper treatment by up to 25%

Comment on "Experimental determination of superconducting parameters for the intermetallic perovskite superconductor MgCNi3_3"

In a recent paper (Phys. Rev. {\bf B 67}, 094502 (2003)) Mao et al. investigated the bias-dependent conductance of mechanical junctions between superconducting MgCNi$_3$ and a sharp W tip. They interpreted their results in terms of 'single-particle tunneling'. We show it is more likely that current transport through those junctions is determined by thermal effects due to the huge normal-state resistivity of MgCNi$_3$. Therefore no conclusion can be drawn about the possible unconventional pairing or strong-coupling superconductivity in MgCNi$_3$.Comment: 2 pages, 1 Fig. Comment on Z. Q. Mao et al. (Phys. Rev. {\bf B 67}, 094502 (2003)

Thermal expansion, heat capacity and magnetostriction of RAl3_3 (R = Tm, Yb, Lu) single crystals

We present thermal expansion and longitudinal magnetostriction data for cubic RAl3 (R = Tm, Yb, Lu) single crystals. The thermal expansion coefficient for YbAl3 is consistent with an intermediate valence of the Yb ion, whereas the data for TmAl3 show crystal electric field contributions and have strong magnetic field dependencies. de Haas-van Alphen-like oscillations were observed in the magnetostriction data of YbAl3 and LuAl3, several new extreme orbits were measured and their effective masses were estimated. Zero and 140 kOe specific heat data taken on both LuAl3 and TmAl3 for T < 200 K allow for the determination of a CEF splitting scheme for TmAl3

Grouping of orally ingested silica nanomaterials via use of an integrated approach to testing and assessment to streamline risk assessment

Background: Nanomaterials can exist in different nanoforms (NFs). Their grouping may be supported by the formulation of hypotheses which can be interrogated via integrated approaches to testing and assessment (IATA). IATAs are decision trees that guide the user through tiered testing strategies (TTS) to collect the required evidence needed to accept or reject a grouping hypothesis. In the present paper, we investigated the applicability of IATAs for ingested NFs using a case study that includes different silicon dioxide, SiO2 NFs. Two oral grouping hypotheses addressing local and systemic toxicity were identified relevant for the grouping of these NFs and verified through the application of oral IATAs. Following different Tier 1 and/or Tier 2 in vitro methods of the TTS (i.e., in vitro dissolution, barrier integrity and inflammation assays), we generated the NF datasets. Furthermore, similarity algorithms (e.g., Bayesian method and Cluster analysis) were utilized to identify similarities among the NFs and establish a provisional group(s). The grouping based on Tier 1 and/or Tier 2 testing was analyzed in relation to available Tier 3 in vivo data in order to verify if the read-across was possible and therefore support a grouping decision. Results: The measurement of the dissolution rate of the silica NFs in the oro-gastrointestinal tract and in the lysosome identified them as gradually dissolving and biopersistent NFs. For the local toxicity to intestinal epithelium (e.g. cytotoxicity, membrane integrity and inflammation), the biological results of the gastrointestinal tract models indicate that all of the silica NFs were similar with respect to the lack of local toxicity and, therefore, belong to the same group; in vivo data (although limited) confirmed the lack of local toxicity of NFs. For systemic toxicity, Tier 1 data did not identify similarity across the NFs, with results across different decision nodes being inconsistent in providing homogeneous group(s). Moreover, the available Tier 3 in vivo data were also insufficient to support decisions based upon the obtained in vitro results and relating to the toxicity of the tested NFs. Conclusions: The information generated by the tested oral IATAs can be effectively used for similarity assessment to support a grouping decision upon the application of a hypothesis related to toxicity in the gastrointestinal tract. The IATAs facilitated a structured data analysis and, by means of the expert’s interpretation, supported read-across with the available in vivo data. The IATAs also supported the users in decision making, for example, reducing the testing when the grouping was well supported by the evidence and/or moving forward to advanced testing (e.g., the use of more suitable cellular models or chronic exposure) to improve the confidence level of the data and obtain more focused information

Current-Carrying Ground States in Mesoscopic and Macroscopic Systems

We extend a theorem of Bloch, which concerns the net orbital current carried by an interacting electron system in equilibrium, to include mesoscopic effects. We obtain a rigorous upper bound to the allowed ground-state current in a ring or disc, for an interacting electron system in the presence of static but otherwise arbitrary electric and magnetic fields. We also investigate the effects of spin-orbit and current-current interactions on the upper bound. Current-current interactions, caused by the magnetic field produced at a point r by a moving electron at r, are found to reduce the upper bound by an amount that is determined by the self-inductance of the system. A solvable model of an electron system that includes current-current interactions is shown to realize our upper bound, and the upper bound is compared with measurements of the persistent current in a single ring.Comment: 7 pager, Revtex, 1 figure available from [email protected]

Release characteristics of selected carbon nanotube polymer composites

Multi-walled carbon nanotubes (MWCNTs) are commonly used in polymer formulations to improve strength, conductivity, and other attributes. A developing concern is the potential for carbon nanotube polymer nanocomposites to release nanoparticles into the environment as the polymer matrix degrades or is mechanically stressed. Here, we review characteristics related to release potential of five sets of polymer systems: epoxy, polyamide, polyurethane, polyethylene, and polycarbonate. Our review includes consideration of general characteristics and use of the polymer (as related to potential MWCNT release) and its MWCNT composites; general potential for nanomaterial release (particularly MWCNTs) due to degradation and mechanical stresses during use; and potential effects of stabilizers and plasticizers on polymer degradation. We examine UV degradation, temperature extremes, acid-base catalysis, and stresses such as sanding. Based on a high-level summary of the characteristics considered, the potential for release of MWCNT with typical, intended consumer use is expected to be low. © 2013 Elsevier Ltd. All rights reserved

Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver

Abstract Background With the continued integration of engineered nanomaterials (ENMs) into everyday applications, it is important to understand their potential for inducing adverse human health effects. However, standard in vitro hazard characterisation approaches suffer limitations for evaluating ENM and so it is imperative to determine these potential hazards under more physiologically relevant and realistic exposure scenarios in target organ systems, to minimise the necessity for in vivo testing. The aim of this study was to determine if acute (24 h) and prolonged (120 h) exposures to five ENMs (TiO2, ZnO, Ag, BaSO4 and CeO2) would have a significantly different toxicological outcome (cytotoxicity, (pro-)inflammatory and genotoxic response) upon 3D human HepG2 liver spheroids. In addition, this study evaluated whether a more realistic, prolonged fractionated and repeated ENM dosing regime induces a significantly different toxicity outcome in liver spheroids as compared to a single, bolus prolonged exposure. Results Whilst it was found that the five ENMs did not impede liver functionality (e.g. albumin and urea production), induce cytotoxicity or an IL-8 (pro-)inflammatory response, all were found to cause significant genotoxicity following acute exposure. Most statistically significant genotoxic responses were not dose-dependent, with the exception of TiO2. Interestingly, the DNA damage effects observed following acute exposures, were not mirrored in the prolonged exposures, where only 0.2–5.0 µg/mL of ZnO ENMs were found to elicit significant (p ≤ 0.05) genotoxicity. When fractionated, repeated exposure regimes were performed with the test ENMs, no significant (p ≥ 0.05) difference was observed when compared to the single, bolus exposure regime. There was < 5.0% cytotoxicity observed across all exposures, and the mean difference in IL-8 cytokine release and genotoxicity between exposure regimes was 3.425 pg/mL and 0.181%, respectively. Conclusion In conclusion, whilst there was no difference between a single, bolus or fractionated, repeated ENM prolonged exposure regimes upon the toxicological output of 3D HepG2 liver spheroids, there was a difference between acute and prolonged exposures. This study highlights the importance of evaluating more realistic ENM exposures, thereby providing a future in vitro approach to better support ENM hazard assessment in a routine and easily accessible manner