313 research outputs found
Synthesis and characterization of nanostructured copperindiumdisulfide and titaniumdioxide thin films for solar cell application
In the wake of the EU brokered agreement, Serbs in Northern Kosovo are more likely to pursue pragmatic co-existence with Pristina
On 19 April, the EU brokered a deal to normalise relations between Serbia and Kosovo. This deal has been opposed by leaders in the majority Serb area of Northern Kosovo, but this view may not be shared by the population, argues Jelena Obradovic-Wochnik. She writes that the potential for EU membership and a pragmatic coexistence with Kosovo means that North Kosovo Serbs may have greater job and economic opportunities; opportunities which may become more important than already weakening political loyalties
The 'silent dilemma' of transitional justice:silencing and coming to terms with the past in Serbia
This article explores the intersections of silence and transitional justice in Serbia, where, it is often suggested, the general public is silent and indifferent about human rights abuses that took place during the former Yugoslav conflicts. It considers both the 'silent' public and the ways in which transitional justice may be complicit in silencing it. Based on scholarship that suggests silences are not absences but rather sites of silent knowledge or a result of silencing, the article explores some of the dynamics hidden within the public's silence: shared knowledge, secret practices and inability to discuss violence. It also considers the ways in which audiences subvert and resist organized transitional justice initiatives or are caught up in a 'silent dilemma' in which they are unable to speak about the past under the discursive conditions created by transitional justice practitioners
Governance in foreign policy-making in Germany and Poland and Polish-German relations:the role of non-state actors
This thesis examines the influence of non-state actors on Polish-German relations by considering foreign policy-making towards Poland in Germany and vice versa. The approach chosen for this thesis is interdisciplinary and takes into consideration literature from domestic politics (Area Studies), Foreign Policy Analysis and International Relations (IR). The thesis argues that IR, by purely looking into the quality of inter-state relations, too often treats these relations as a result of policies emanating from the relevant governments, without considering the policiesâ background. Therefore, the thesis argues that it is necessary to engage with the domestic factors which might explain where foreign policies come from. It points out that non-state actors influence governmentsâ choices by supplying resources, and by cooperating or competing with the government on an issue at stake. In order to determine the degree of influence that non-state actors can have on foreign policymaking two variables are examined: the institutionalisation of the state relations in question; and the domestic structures of the relevant states. Specifically, the thesis examines the institutionalisation of Polish-German relations, and examines Germanyâs and Polandâs domestic structures and their effect on the two statesâ foreign policy-making in general. Thereafter, the thesis uses case studies in order to unravel the influence of non-state actors on specific foreign policies. Three case studies are examined in detail: (i) Polandâs EU accession negotiations with regard to the free movement of capital chapter of the acquis communautaire; (ii) Germanyâs EU 2004 Eastern Enlargement negotiations with regard to the free movement of workers chapter of the acquis communautaire; and (iii) Germanyâs decision to establsh a permanent exhibition in Berlin that will depict the expulsions of millions of Germans from the East following WWII
The everyday at the border: Examining visual, material and spatial intersections of international politics along the âBalkan Routeâ
This article examines the intersections between the visual, spatial and material and considers how these interactions capture the border politics of everyday âbanalâ objects. We do this by looking at some of the objects and things that constitute the âBalkan Routeâ through Europe: posters, signs, directions, notices, flyers and maps produced by state authorities and volunteer-led aid networks. We use objects to reflect more broadly on how seemingly banal and everyday things become incorporated into the political work of states and become constitutive of fluid borders. We argue that everyday objects become visualisations of states and authorities, and help to make and regulate physical spaces. We show how each visual object encountered along the route gives us a broader insight into the macropolitics of European border regimes, specifically the effects of âclosed bordersâ and the criminalisation of aid networks. The article pushes forward the âaesthetic turnâ debate in international relations by bringing in insights from political geography and materialism, and suggests that a walking methodology can be a productive way of encountering the visual and understanding how its physical location creates political effects
Making territory through infrastructure: The governance of natural gas transit in Europe
AbstractRecent political and military events in Ukraine have brought into sharp focus concerns over the security of European gas supplies from Russia. At the same time, the creation of an infrastructural and political âenergy unionâ has become a key stated priority for the governing bodies of the European Union. Both contingencies have highlighted the 28-nation blocâs dependence on energy sources well beyond its state boundaries, underpinned by the existence of a transnational network for the transport and distribution of natural gas. We develop a theoretical framework predicated upon assemblage and governance approaches to explore the regulatory practices and spatial features associated with this hitherto largely unexplored infrastructural realm. Qualitative evidence from interviews, policy documents and media reports is interrogated interpretively and with the aid of social network analysis techniques. The paper reveals the existence of a socio-technical assemblage for the transmission of natural gas across national boundaries emerging as a result of the erosion of decision-making power away from established state actors, and the rise of new institutional orders. While undermining the organizational arrangements that have traditionally dominated the European gas sector, these contingencies also challenge existing understandings of transnational energy governance as they apply to overland gas transit
Urban geographies of refugee journeys: biopolitics, neoliberalism and contestation over public space in Belgrade
Liberal Violence and the Racial Borders of the European Union
This paper examines how racial violence underpins the European Unionâs border regime. Drawing on two case studies, in northern France and the Balkans, we explore how border violence manifests in divergent ways: from the direct physical violence which is routine in Croatia, to more subtle forms of violence evident in the governance of migrants and refugees living informally in Calais, closer to Europeâs geopolitical centre. The use of violence against people on the move sits uncomfortably with the liberal, postâracial selfâimage of the European Union. Drawing upon the work of postcolonial scholars and theories of violence, we argue that the various violent technologies used by EU states against migrants embodies the inherent logics of liberal governance, whilst also reproducing liberalismâs tendency to overlook its racial limitations. By interrogating how and why border violence manifests we draw critical attention to the racialised ideologies within which it is predicated. This paper characterises the EU border regime as a form of âliberal violenceâ that seeks to elide both its violent nature and its racial underpinnings
Die Funktion der Cochaperone FKBP51, FKBP52 und p23 bei der Signaltransduktion der Corticoidrezeptoren
Um die Therapiemöglichkeiten bei depressiven Störungen zu verbessern, ist die Kenntnis der molekularen Grundlagen dieser Erkrankungen notwendig. Die erhöhten basalen Cortisolwerte im Serum von depressiven Patienten und die gestörte negative RĂŒckkopplung der HPA-Achse sind Hinweise darauf, daĂ die Funktionsweise der Rezeptoren fĂŒr Corticoide wie Cortisol eingeschrĂ€nkt ist. Die vorliegende Arbeit beschĂ€ftigt sich mit den Cochaperonen fĂŒr die Corticoid-Signaltransduktion, insbesondere den Immunophiline FKBP51 und FKBP52, sowie p23. FĂŒr die Immunophiline wurde entdeckt, daĂ fĂŒr ihren Beitrag zu einer effizienten Aktivierung Corticoid-abhĂ€ngiger Promotoren drei Eigenschaften von Bedeutung sind: 1. Interaktion mit Hsp90, um ĂŒberhaupt den Zugang zum Heterokomplex zu erhalten, 2. Wechselwirkung mit Dynein, um den nukleĂ€ren Transport der Rezeptoren zu begĂŒnstigen und 3. die Peptidyl-Prolyl-Isomerase-AktivitĂ€t. Diese Postulate grĂŒnden sich auf die folgenden experimentellen Befunde: Das Immunophilin FKBP51 reduziert als Bestandteil des Heterokomplexes mit Hsp90 und den Corticoidrezeptoren sowohl die BindungsaffinitĂ€t (Denny et al., 2000) als auch die nukleĂ€re Translokation des Glucocorticoidrezeptors (GRs) und des Mineralocorticoidrezeptors (MRs). Im Gegensatz zu seinem Homologen FKBP52 zeigt FKBP51 nur eine geringe Interaktion mit dem Motorprotein Dynein, welches fĂŒr den retrograden Transport verantwortlich ist. Durch EinfĂŒhrung einer Punktmutation, die die Peptidyl-Prolyl-Isomerase-AktivitĂ€t inaktiviert, konnte gezeigt werden, daĂ FKBP51 diese AktivitĂ€t nicht fĂŒr seine inhibierende Wirkung benötigt. Im Gegensatz dazu liefert die PPIase-AktivitĂ€t von FKBP52 einen aktiven Beitrag fĂŒr die FunktionalitĂ€t der Corticoidrezeptoren, weil die analoge Mutation in FKBP52 zur einer Hemmung der Transaktivierung und nukleĂ€ren Translokation des GRs und des MRs fĂŒhrt. Da diese Mutante immer noch mit Dynein interagiert, ist allein die Wechselwirkung mit diesem Motorprotein offensichtlich nicht ausreichend fĂŒr die volle GR-AktivitĂ€t.
Des weiteren konnte gezeigt werden, daĂ Polymorphismen im FKBP51-Gen nicht nur mit dem Erfolg einer Antidepressivabehandlung korrelieren, sondern auch mit den Proteinmengen von FKPB51 in Lymphozyten.
SchlieĂlich wurde die Bedeutung von p23 analysiert, einem kleinen Cochaperon von Hsp90, dem aber auch eigene ChaperonaktivitĂ€t zugeschrieben wurde. Durch gezielte Mutationen im p23-Protein war es möglich, seine ChaperonaktivitĂ€t getrennt von seiner Cochaperon-Funktion zu untersuchen. Dabei stellte sich heraus, daĂ p23 fĂŒr die Hemmung der GR-abhĂ€ngigen Transkription nur als Hsp90-Cochaperon fungiert, weil zwar seine Interaktion mit Hsp90 fĂŒr diesen Effekt notwendig war, nicht aber seine ChaperonaktivitĂ€t. Um die beschriebene nukleĂ€re Rolle von p23, die zum Zerfall von GR-Transkriptionskomplexen fĂŒhrt, zu untersuchen, wurde ein konstitutiv nukleĂ€rer GR verwendet. Auch hier benötigt p23 fĂŒr die Hemmung des Rezeptors seine Hsp90-Interaktion, nicht aber seine ChaperonaktivitĂ€t.
Diese Arbeit leistet einen Beitrag zum VerstĂ€ndnis der Rolle von Chaperonen in der Steroid-Signaltransduktion. DarĂŒber hinaus wurden starke Hinweise fĂŒr eine mögliche Rolle von FKBP51 bei der Depression entdeckt
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