Improved synthesis of [18F] fallypride and characterization of a Huntington’s disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors

Dopamine receptors are involved in pathophysiology of neuropsychiatric diseases, including Huntington’s disease (HD). PET imaging of dopamine D2 receptors (D2R) in HD patients has demonstrated 40% decrease in D2R binding in striatum, and D2R could be a reliable quantitative target to monitor disease progression. A D2/3R antagonist, [18F] fallypride, is a high-affinity radioligand that has been clinically used to study receptor density and occupancy in neuropsychiatric disorders. Here we report an improved synthesis method for [18F]fallypride. In addition, high molar activity of the ligand has allowed us to apply PET imaging to characterize D2/D3 receptor density in striatum of the recently developed zQ175DN knock-in (KI) mouse model of HD.Peer reviewe

Covariates used to model the distribution of swine farms in the United States.

<p>^a Covariates with prefix <i>d</i> are measured as linear distances (m) to the environmental or anthropogenic feature.</p><p>^b Sources and references: Land-cover categories: 2006 National Land Cover Dataset [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0140338#pone.0140338.ref021" target="_blank">21</a>]; Topography: National Elevation Dataset [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0140338#pone.0140338.ref022" target="_blank">22</a>]; Climate: WORLDCLIM database [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0140338#pone.0140338.ref023" target="_blank">23</a>]; Transportation: Environmental Systems Research Institute (ESRI) World Transportation [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0140338#pone.0140338.ref024" target="_blank">24</a>].</p><p>^c Open areas = Cropland + Pasture + Grassland + low and medium intensity Developed areas</p><p>Covariates used to model the distribution of swine farms in the United States.</p