Social acceptance of carbon capture and storage (CCS) from industrial applications

To limit global warming, the use of carbon capture and storage technologies (CCS) is considered to be of major importance. In addition to the technical-economic, ecological and political aspects, the question of social acceptance is a decisive factor for the implementation of such low-carbon technologies. This study is the first literature review addressing the acceptance of industrial CCS (iCCS). In contrast to electricity generation, the technical options for large-scale reduction of CO2 emissions in the energy-intensive industry sector are not sufficient to achieve the targeted GHG neutrality in the industrial sector without the use of CCS. Therefore, it will be crucial to determine which factors influence the acceptance of iCCS and how these findings can be used for policy and industry decision-making processes. The results show that there has been limited research on the acceptance of iCCS. In addition, the study highlights some important differences between the acceptance of iCCS and CCS. Due to the technical diversity of future iCCS applications, future acceptance research must be able to better address the complexity of the research subject

Hemmnisanalyse zu Änderungen des Nutzerverhaltens und Optimierung der Organisationsprozesse zur Schaffung von Flexibilität in gewerblich und industriell genutzten Gebäuden

Ziel dieses Teilvorhabens innerhalb des FlexGeber-Projektes war die Initiierung und Begleitung eines Prozesses zur Identifikation und (idealerweise späteren) Realisierung von Effizienz-, Erneuerbaren- und Flexibilitätspotenzialen in den Industriebetrieben Taifun-Tofu GmbH (Lebensmittel) und Hermann Peter KG (Baustoffe). Dazu haben die Forschenden jeweils in einem Workshop relevante Akteure zusammengebracht und Wissen zur Bestimmung und Bewertung von Flexibilitäten aus technischer, rechtlich-politischer sowie strukturell-organisatorischer Sicht erarbeitet und vermittelt. Gemeinsam klärten sie, welche Informationen in welchem Format für Unternehmen erforderlich und relevant sind, um Flexibilitätsoptionen identifizieren und umsetzen zu können. Insgesamt gliedert sich die methodische Vorgehensweise in vier zentrale Arbeitsschritte: Vor-Ort-Begehungen bei den Reallaboren, Identifikation technischer Hotspots, Akteursworkshop sowie abschließende Auswertung. Der vorliegende Teilbericht dokumentiert diesen Prozess und fokussiert auf die Identifikation von möglichen Effizienz-, Erneuerbaren- und Flexibilitätsoptionen und der Erfassung von Hemmnissen, die einer Umsetzung von Maßnahmen zur Erschließung der Potenziale bei den Praxispartnern entgegenstehen. Da die Workshops vornehmlich auf die Unternehmen Taifun-Tofu und Hermann Peter ausgerichtet waren, fokussiert dieser Bericht auf Hemmnisse, die diese Unternehmen bzw. Unternehmen dieser Branchen betreffen. Darüber hinaus ist ein Kapitel zu Hemmnissen, die sich aus dem Demonstrationsvorhaben des Fraunhofer ISE-Campus (Ausbau des Kältenetzes und Installation von Kältespeichern) ableiten, ist in diesem Bericht enthalten

Dimethylfumarate Impairs Neutrophil Functions

Host defense against pathogens relies on neutrophil activation. Inadequate neutrophil activation is often associated with chronic inflammatory diseases. Neutrophils also constitute a significant portion of infiltrating cells in chronic inflammatory diseases, for example, psoriasis and multiple sclerosis. Fumarates improve the latter diseases, which so far has been attributed to the effects on lymphocytes and dendritic cells. Here, we focused on the effects of dimethylfumarate (DMF) on neutrophils. In vitro, DMF inhibited neutrophil activation, including changes in surface marker expression, reactive oxygen species production, formation of neutrophil extracellular traps, and migration. Phagocytic ability and autoantibody-induced, neutrophil-dependent tissue injury ex vivo was also impaired by DMF. Regarding the mode of action, DMF modulates—in a stimulus-dependent manner-neutrophil activation using the phosphoinositide 3-kinase/Akt-p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 pathways. For in vivo validation, mouse models of epidermolysis bullosa acquisita, an organ-specific autoimmune disease caused by autoantibodies to type VII collagen, were employed. In the presence of DMF, blistering induced by injection of anti-type VII collagen antibodies into mice was significantly impaired. DMF treatment of mice with clinically already-manifested epidermolysis bullosa acquisita led to disease improvement. Collectively, we demonstrate a profound inhibitory activity of DMF on neutrophil functions. These findings encourage wider use of DMF in patients with neutrophil-mediated diseases

Gesellschaftliche Akzeptanzfragen bei der Umsetzung von Wasserstofftechnologien

Die Bundesrepublik Deutschland hat sich zum Ziel gesetzt, bis 2045 klimaneutral zu werden. Das kann nur funktionieren, wenn fossile Rohstoffe durch erneuerbare Energien ersetzt werden - insbesondere in den Bereichen Industrie und Verkehr. Ein wesentlicher Baustein in diesem Transformationsprozess ist die Errichtung einer Wasserstoffwirtschaft, innerhalb derer Strom aus erneuerbaren Energien in grünen Wasserstoff umgewandelt und dieser als Energieträger vor allem in den Bereichen Industrie und Verkehr angewendet wird

The Berlin Aptitude Test for Psychology – BSF-P

Das Studium der Psychologie ist in Deutschland äußerst beliebt. Aufgrund begrenzt verfügbarer Studienplätze ist eine Auswahl der Bewerber_innen notwendig. Zur Selektion geeigneter Bewerber_innen wurde bisher vorwiegend die Note der Hochschulzugangsberechtigung verwendet. Dies ist seit einem Urteil des Bundesverfassungsgerichts von 2017 nicht mehr zulässig. Das Land Berlin erteilte daher den Auftrag zur Entwicklung eines Studierfähigkeitstests für das Fach Psychologie. Aufbauend auf einer ausführlichen Anforderungsanalyse wurde der Berliner Studierfähigkeitstest – Psychologie zur Erfassung studienfachbezogener Studierfähigkeit entwickelt und an zwei Konstruktionsstichproben revidiert. Die Messwerte des BSF-P zeigen gute Reliabilität und Validität und können zur Auswahl von Studierenden verwendet werden. Der Einsatz des Verfahrens erlaubt zudem eine faire Auswahl von Bewerber_innen und führt langfristig zu einer diverseren Studierendenschaft im Fach Psychologie.Studying psychology is extremely popular in Germany. Because of the limited number of available spots, selection of applicants is necessary. To date, grades on the high school diploma or an equivalent were mainly used to select suitable applicants. Following a ruling by the Federal Constitutional Court in 2017, however, this is no longer permissible. Therefore, the State of Berlin commissioned the development of a study aptitude test for the Bachelor of Psychology. Based on a detailed requirements analysis, the Berlin Aptitude Test for Psychology (BSF-P) was developed to assess subject-related study ability. The test was developed and revised on two different samples and finally applied for selecting applicants at the Humboldt-Universität zu Berlin in 2021. The reliability and validity estimates of the test scores of the BSF-P suggest that the test is applicable for the selection of students in a high-stakes context. This procedure allows fair selection of applicants and in the long term leads to a more diverse student body in psychology.Peer Reviewe

Empirical Bayes analysis of single nucleotide polymorphisms

<p>Abstract</p> <p>Background</p> <p>An important goal of whole-genome studies concerned with single nucleotide polymorphisms (SNPs) is the identification of SNPs associated with a covariate of interest such as the case-control status or the type of cancer. Since these studies often comprise the genotypes of hundreds of thousands of SNPs, methods are required that can cope with the corresponding multiple testing problem. For the analysis of gene expression data, approaches such as the empirical Bayes analysis of microarrays have been developed particularly for the detection of genes associated with the response. However, the empirical Bayes analysis of microarrays has only been suggested for binary responses when considering expression values, i.e. continuous predictors.</p> <p>Results</p> <p>In this paper, we propose a modification of this empirical Bayes analysis that can be used to analyze high-dimensional categorical SNP data. This approach along with a generalized version of the original empirical Bayes method are available in the R package siggenes version 1.10.0 and later that can be downloaded from <url>http://www.bioconductor.org</url>.</p> <p>Conclusion</p> <p>As applications to two subsets of the HapMap data show, the empirical Bayes analysis of microarrays cannot only be used to analyze continuous gene expression data, but also be applied to categorical SNP data, where the response is not restricted to be binary. In association studies in which typically several ten to a few hundred SNPs are considered, our approach can furthermore be employed to test interactions of SNPs. Moreover, the posterior probabilities resulting from the empirical Bayes analysis of (prespecified) interactions/genotypes can also be used to quantify the importance of these interactions.</p

Comparison of total parathyroidectomy without autotransplantation and without thymectomy versus total parathyroidectomy with autotransplantation and with thymectomy for secondary hyperparathyroidism: TOPAR PILOT-Trial

<p>Abstract</p> <p>Background</p> <p>Secondary hyperparathyroidism (sHPT) is common in patients with chronic renal failure. Despite the initiation of new therapeutic agents, several patients will require parathyroidectomy (PTX). Total PTX with autotransplantation of parathyroid tissue (TPTX+AT) and subtotal parathyroidectomy (SPTX) are currently considered as standard surgical procedures in the treatment of sHPT. Recurrencerates after TPTX+AT or SPTX are between 10% and 12% (median follow up: 36 months).</p> <p>Recent retrospective studies demonstrated a lower rate of recurrent sHPT of 0–4% after PTX without autotransplantation and thymectomy (TPTX) with no higher morbidity when compared to the standard procedures. The observed superiority of TPTX is flawed due to different definitions of outcomes, varying follow up periods and different surgical treatment strategies (with and without thymectomy).</p> <p>Methods/Design</p> <p>Patients with sHPT (intact parathyroid hormone > 10 times above the upper limit of normal) on long term dialysis (>12 months) will be randomized either to TPTX or TPTX+AT and followed for 36 months. Outcome parameters are recurrence rates of sHPT, frequencies of reoperations due to refractory hypoparathyroidism or recurrent/persistent hyperparathyroidism, postoperative morbidity and mortality and quality of life. 50 patients per group will be randomized in order to obtain relevant frequencies of outcome parameters that will form the basis for a large scale confirmatory multicentred randomized controlled trial.</p> <p>Discussion</p> <p>sHPT is a disease with a high incidence in patients with chronic renal failure. Even a small difference in outcomes will be of clinical relevance. To assess sufficient data about the rate of recurrent sHPT after both methods, a multicentred, randomized controlled trial (MRCT) under standardized conditions is mandatory.</p> <p>Due to the existing uncertainties the calculated number of patients necessary in each treatment arm (n > 4000) makes it impossible to perform this study as a confirmatory trial. Therefore estimates of different outcomes are performed using a pilot MRCT comparing 50 versus 50 randomized patients in order to establish a hypothesis that can be tested thereafter.</p> <p>If TPTX proves to have a lower rate of recurrent sHPT, no relevant disadvantages and no higher morbidity than TPTX+AT, current surgical practice may be changed.</p> <p>Trial registration</p> <p>International Standard Randomized Controlled Trial Number Registration (ISRCTN86202793)</p

Deep-Sea Nematodes Actively Colonise Sediments, Irrespective of the Presence of a Pulse of Organic Matter: Results from an In-Situ Experiment

A colonisation experiment was performed in situ at 2500 m water depth at the Arctic deep-sea long-term observatory HAUSGARTEN to determine the response of deep-sea nematodes to disturbed, newly available patches, enriched with organic matter. Cylindrical tubes,laterally covered with a 500 µm mesh, were filled with azoic deep-sea sediment and 13C-labelled food sources (diatoms and bacteria). After 10 days of incubation the tubes were analysed for nematode response in terms of colonisation and uptake. Nematodes actively colonised the tubes,however with densities that only accounted for a maximum of 2.13% (51 ind.10 cm−2) of the ambient nematode assemblages. Densities did not differ according to the presence or absence of organic matter, nor according to the type of organic matter added. The fact that the organic matter did not function as an attractant to nematodes was confirmed by the absence of notable 13C assimilation by the colonising nematodes. Overall, colonisationappears to be a process that yields reproducible abundance and diversity patterns, with certain taxa showing more efficiency. Together with the high variability between the colonising nematode assemblages, this lends experimental support to the existence of a spatio-temporal mosaic that emerges from highly localised, partially stochastic community dynamics