Der (Stimmen-)Spalter. Die Figur des neidischen Nebenbuhlers im ›Reinfried von Braunschweig‹

Der Beitrag beschreibt den Nebenbuhler, der im ›Reinfried von Braunschweig‹ entworfen wird, als Beispiel eines Interesses für Figurationen des Dritten in der mittelhochdeutschen Literatur. Die Konjunktur einer dritten, binäre Ordnungen und abschließende Synthesen herausfordernden Größe in (post-)modernen Theorien spiegelt sich auf literarischer Ebene in der Fokussierung auf Figuren in Zwischenpositionen wider, welche so auch für die literaturwissenschaftliche Auseinandersetzung Attraktivität gewinnen. Die hier ins Zentrum gestellte Figur zeigt, dass nicht ausschließlich (post-)moderne Texte eine Sensibilität für solche Figuren des Dritten, die durch sie aufgeworfenen Fragen und ermöglichten narrativen Experimente besitzen. Der eigentlich eine typische Nebenrolle besetzende Ritter erhält eine komplexe Ausgestaltung, welche sich sowohl als Reflexion über die Prinzipien der Minne als auch als Ausgangspunkt einer faszinierenden Erzähldynamik mit dialogischen Momenten erweist

Soft tissue mixed tumor of the hand

Mixed tumors are relatively common in the skin and salivary glands, but extremely rare in soft tissues, often resulting in diagnostic problems. The occurrence of these tumors in the hand is especially limited. In this article we report the clinical, radiological, and histological features of a mixed tumor of the hypothenar region of the right hand

Bioresorbable drug-eluting magnesium-alloy scaffold for treatment of coronary artery disease

The introduction of metallic drug-eluting stents has reduced the risk of restenosis and widened the indications of percutaneous coronary intervention in treatment of coronary artery disease. However, this medical device can induce hypersensitive reaction that interferes with the endothelialization and healing process resulting in late persistent or acquired malapposition of the permanent metallic implant. Delayed endotheliaization and malapposition may lead to late and very late stent thrombosis. Bioresorbable scaffolds (BRS) have been introduced to potentially overcome these limitations, as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. Magnesium is an essential mineral needed for a variety of physiological functions in the human body and its bioresorbable alloy has the strength-to-weight ratio comparable with that of strong aluminum alloys and alloy steels. The aim of this review is to present the new developments in Magnesium BRS technology, to describe its clinical application and to discuss the future prospects of this innovative therapy

The Effects of Protonated Nicotine on Stem Cells from Human Exfoliated Deciduous Teeth (Shed)

Background: The use of electronic cigarettes (ECs) and vaping products has been a significant concern in recent years, due to increased usage of these products amongst the general population as well as juveniles. With the innovation of nicotine salts in newer generations EC such as the JUUL, nicotine delivery has become easier and much higher. There is limited research on the effects of nicotine on oral health and specifically dental pulp stem cells (DPCS), the cells that provide protection and reparation to the teeth. Objectives: This study aimed to evaluate the effects of protonated nicotine on apoptosis, necrosis, viability, and gene expression of stem cells from human exfoliated deciduous teeth (SHEDs) over time. Methods: Characterized SHEDs were used in this study. The cells were seeded in 12-well cell culture plates at a concentration of 3.5 x 104 cells/well. Negative (non-treated) control cells, positive apoptosis control cells (100 nM Staurosporine 2 hours before collection) and positive necrosis control cells (0.2% Tritonax 10 minutes before collection) were compared with cells treated with 15 ng/mL, 30 ng/mL, and 300 ng/mL nicotine in media. Triplicates were performed for each experiment for all SHEDs isolates. SHEDs were dosed daily with the appropriate concentrations of nicotine in media and collected after 3, 7, and 10 day intervals. After each time points, cells were evaluated for immunofluorescence for caspase-3; % of apoptotic, necrotic, and viable cells; and RNA isolation and RT-qPCR gene expression of BAX, BCL2, DMP-1, RUNX2, and ALP. Results: Mean percentage for apoptosis, necrosis, and viability of SHEDs were not significantly affected at nicotine concentrations of 0 ng/mL, 15 ng/mL, 30 ng/mL and 300 ng/mL after 3, 7, and 10 days of exposure. This was further supported by the results of immunofluorescence experiments, which showed that different concentrations of nicotine over time appear to have little effect on the cleavage of caspase-3. Furthermore, trends in RT-PCR suggested that gene expression for Bcl-2 and BAX in nicotine treated cells were not affected by exposure to different concentrations of nicotine at any time point. Finally, RT-PCR also showed no effect in gene expression for dentin matrix acidic phosphoprotein 1 (DMP-1), Runt-related transcription factor 2 (RUNX2), and Alkaline phosphatase (ALP). Conclusions: This study has demonstrated that apoptosis, necrosis, viability, and gene expression of SHEDs were not significantly affected at nicotine concentration found in the blood after 3, 7, and 10 days. However, it is unclear how long-term exposure to nicotine might affect SHEDs and oral health. The results of this current study may suggest that short term use of EC and nicotine exposure does not affect SHEDs significantly. More research is needed to understand the effects and mechanism of nicotine on DPSCs

Resolution of Fundic Gland Polyposis following Laparoscopic Magnetic Sphincter Augmentation and Subsequent Cessation of Proton Pump Inhibitors

Gastric polyps occur from a variety of sources and are found commonly on upper endoscopy. We present the case of a 49-year-old female who presented for evaluation for antireflux surgery with a history of fundic gland polyposis who required twice-daily proton pump inhibitors (PPIs) for control of her gastric reflux. After verifying that she met criteria for surgery, she underwent an uncomplicated laparoscopic magnetic sphincter augmentation placement. With the cessation of PPIs following surgery, the fundic gland polyposis resolved. Fundic gland polyps may occur sporadically or within certain syndromes, such as familial adenomatous polyposis. Multiple possible inciting factors exist, including the use of PPIs. This is the first reported case of the resolution of numerous fundic gland polyps following the completion of laparoscopic magnetic sphincter augmentation

Paranuclear blue inclusions: An aid in the cytopathologic diagnosis of primary and metastatic pulmonary small-cell carcinoma

Accurate diagnosis of small‐cell carcinoma of the lung (SCLC) is clinically important because of the therapeutic implications. SCLC must be distinguished from non‐small‐cell carcinoma (NSCLC) and lymphoma. Paranuclear blue inclusions (PBIs) were recently described as a feature of metastatic SCLC on air‐dried Wright‐stained bone marrow aspirate smears. To determine the utility of PBIs in distinguishing SCLC from NSCLC and lymphoma, we evaluated air‐dried Diff‐Quik‐stained smears from 103 fine‐needle aspiration (FNA) specimens and 14 touch imprint specimens. PBIs were identified in 24 (89%) of 27 cases of SCLC, in 6 (9%) of 64 non‐small‐cell carcinomas (P \u3c 0.00001), and in two (8%) of the 26 lymphoma cases (P \u3c 0.00001). No PBIs were seen on any of the alcohol‐fixed Papanicolaou or hematoxylin‐eosin (HandE) stained smears examined. In conclusion, PBIs appear to be a feature of SCLC on air‐dried cytologic material stained with Romanowsky type stains. In the presence of cytologic features of SCLC, the identification of PBIs provides a useful diagnostic feature for diferentiating between SCLC and NSCLC carcinomas, and between SCLC and lymphomas in FNA specimens and touch imprints from surgical specimens