Supersonic combustion engine testbed, heat lightning

The design of a supersonic combustion engine testbed (SCET) aircraft is presented. The hypersonic waverider will utilize both supersonic combustion ramjet (SCRAMjet) and turbofan-ramjet engines. The waverider concept, system integration, electrical power, weight analysis, cockpit, landing skids, and configuration modeling are addressed in the configuration considerations. The subsonic, supersonic and hypersonic aerodynamics are presented along with the aerodynamic stability and landing analysis of the aircraft. The propulsion design considerations include: engine selection, turbofan ramjet inlets, SCRAMjet inlets and the SCRAMjet diffuser. The cooling requirements and system are covered along with the topics of materials and the hydrogen fuel tanks and insulation system. A cost analysis is presented and the appendices include: information about the subsonic wind tunnel test, shock expansion calculations, and an aerodynamic heat flux program

PORTABLE IMAGE-BASED HIGH PERFORMANCE MOBILE MAPPING SYSTEM IN UNDERGROUND ENVIRONMENTS – SYSTEM CONFIGURATION AND PERFORMANCE EVALUATION

The progression in urbanization increases the need for different types of underground infrastructure. Consequently, infrastructure and life cycle management are rapidly gaining in importance. Mobile reality capturing systems and cloud-based services exploiting georeferenced metric 3D imagery are already extensively used for infrastructure management in outdoor environments. These services minimise dangerous and expensive field visits or measurement campaigns. In this paper, we introduce the BIMAGE Backpack, a portable image-based mobile mapping system for 3D data acquisition in indoor environments. The system consists of a multi-head panorama camera, two multi-profile laser scanners and an inertial measurement unit. With this system, we carried out underground measurement campaigns in the Hagerbach Test Gallery, located in Flums Hochwiese, Switzerland. For our performance evaluations in two different tunnel sections, we employed LiDAR SLAM as well as advanced image-based georeferencing. The obtained absolute accuracies were in the range from 6.2 to 7.4 cm. The relative accuracy, which for many applications is even more important, was in the range of 2–6 mm. These figures demonstrate an accuracy improvement of the subsequent image-based georeferencing over LiDAR SLAM by about an order of magnitude. The investigations show the application potential of image-based portable mobile mapping systems for infrastructure inventory and management in large underground facilities

Unsteady Flow and Whirl-Inducing Forces in Axial-Flow Compressors: Part I—Experiment

An experimental and theoretical investigation has been conducted to evaluate the effects seen in axial-flow compressors when the centerline of the rotor is displaced from the centerline of the static structure of the engine. This creates circumferentially nonuniform rotor-tip clearances, unsteady flow, and potentially increased clearances if the rotating and stationary parts come in contact. The result not only adversely affects compressor stall margin, pressure rise capability, and efficiency, but also generates an unsteady, destabilizing, aerodynamic force, called the Thomas/Alford force, which contributes significantly to rotor whirl instabilities in turbomachinery. Determining both the direction and magnitude of this force in compressors, relative to those in turbines, is especially important for the design of mechanically stable turbomachinery components. Part I of this two-part paper addresses these issues experimentally and Part II presents analyses from relevant computational models. Our results clearly show that the Thomas/Alford force can promote significant backward rotor whirl over much of the operating range of modern compressors, although some regions of zero and forward whirl were found near the design point. This is the first time that definitive measurements, coupled with compelling analyses, have been reported in the literature to resolve the long-standing disparity in findings concerning the direction and magnitude of whirl-inducing forces important in the design of modern axial-flow compressors

Vortices in the presence of a nonmagnetic atom impurity in 2D XY ferromagnets

Using a model of nonmagnetic impurity potential, we have examined the behavior of planar vortex solutions in the classical two-dimensional XY ferromagnets in the presence of a spin vacancy localized out of the vortex core. Our results show that a spinless atom impurity gives rise to an effective potential that repels the vortex structure.Comment: 6 pages, 2 figures, RevTex

Effects of non-axisymmetric tip clearance on axial compressor performance and stability

September 1997Statement of responsibility on title-page reads: M.B. Graf, T.S. Wong, E.M. Greitzer, F.E. Marble, C.S. Tan, H-W Shin, D.C. WislerIncludes bibliographical references (pages 34-35)The effects of circumferentially non-uniform tip clearance on axial compressor performance and stability have been investigated experimentally and analytically. A theoretical model for compressor behavior with non-axisymmetric tip clearance has been developed and used to design a series of first-of-a-kind experiments on a four-stage, low speed compressor. The experiments and computational results together show clearly the central physical features and controlling parameters of compressor response to non-axisymmetric tip clearance. It was found that the loss in stall margin was more severe than that estimated based on average clearance. The stall point was, in fact, closer to that obtained with uniform clearance at the maximum clearance level. The circumferential length scale of the tip clearance (and accompanying flow asymmetry) was an important factor in determining the stall margin reduction.For the same average clearance, the loss in peak pressure rise was 50% higher for an asymmetry with fundamental wavelength equal to the compressor circumference than with wavelength equal to one-half the circumference. The clearance asymmetry had much less of an effect on peak efficiency; the measured maximum efficiency decrease obtained was less than 0.4 percent compared to the 8% decrease in peak pressure rise due to the asymmetric clearance. The efficiency penalty due to non-axisymmetric tip clearance was thus close to that obtained with a uniform clearance at the circumferentially-averaged level. The theoretical model accurately captured the decreases in both steady-state pressure rise and stable operating range which are associated with clearance asymmetry.It also gave a good description of the observed trends of (i) increasing velocity asymmetry with decreasing compressor flow, and (ii) decreasing effect of clearance asymmetry with decreasing dominant wavelength of the clearance distribution. The time resolved data showed that the spatial structure of the pre-stall propagating disturbances in the compressor annulus was well represented and that the stability limiting process could be linked to the unsteady structure of these disturbance modes. The model was also utilized for parametric studies to define how compressor performance and stability is affected by the circumferential distribution of clearance, steady-state compressor pressure-rise characteristic, and system dynamic parameters. Sensitivity to clearance asymmetry was found to fall off strongly with the (asymmetry-related) reduced frequency and to increase with peak pressure rise and increasing curvature of the characteristic near the peak.Sponsored by the Air Force Office of Scientific Research, and the Air Force Aero Propulsion Technology (AFRAPT) Progra

Evolution of project planning tools in a matrix organization

Until recently, the Corporate Construction Program at Sandia was experiencing difficulties in managing projects: poor planning and cost estimating caused schedule and budget problems. The first step taken was a Microsoft {reg_sign} Project schedule that provides a standard template for scheduling individual construction projects. It is broken down according to the life cycle of the project and prevents the project team from leaving out an important item. A WBS (work breakdown structure) dictionary was also developed that describes how capital and operating funds are used to develop, design, construct, equip, and manage projects. We also developed a matrix chart that maps the planning guide against the major types of construction projects at Sandia. The guide, dictionary, and matrix chart offer enough flexibility that the project manager can make choices about how to structure work, yet ensure that all work rolls up to the cost categories and key DOE WBS elements. As requirements change, the tools can be updated; they also serve as training tools for new project team members

The role of kinetic context in apparent biased agonism at GPCRs

Biased agonism describes the ability of ligands to stabilize different conformations of a GPCR linked to distinct functional outcomes and offers the prospect of designing pathway-specific drugs that avoid on-target side effects. This mechanism is usually inferred from pharmacological data with the assumption that the confounding influences of observational (that is, assay dependent) and system (that is, cell background dependent) bias are excluded by experimental design and analysis. Here we reveal that ‘kinetic context’, as determined by ligand-binding kinetics and the temporal pattern of receptor-signalling processes, can have a profound influence on the apparent bias of a series of agonists for the dopamine D2 receptor and can even lead to reversals in the direction of bias. We propose that kinetic context must be acknowledged in the design and interpretation of studies of biased agonism

Ligand-Induced Modulation of the Free-Energy Landscape of G Protein-Coupled Receptors Explored by Adaptive Biasing Techniques

Extensive experimental information supports the formation of ligand-specific conformations of G protein-coupled receptors (GPCRs) as a possible molecular basis for their functional selectivity for signaling pathways. Taking advantage of the recently published inactive and active crystal structures of GPCRs, we have implemented an all-atom computational strategy that combines different adaptive biasing techniques to identify ligand-specific conformations along pre-determined activation pathways. Using the prototypic GPCR β2-adrenergic receptor as a suitable test case for validation, we show that ligands with different efficacies (either inverse agonists, neutral antagonists, or agonists) modulate the free-energy landscape of the receptor by shifting the conformational equilibrium towards active or inactive conformations depending on their elicited physiological response. Notably, we provide for the first time a quantitative description of the thermodynamics of the receptor in an explicit atomistic environment, which accounts for the receptor basal activity and the stabilization of different active-like states by differently potent agonists. Structural inspection of these metastable states reveals unique conformations of the receptor that may have been difficult to retrieve experimentally

Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy

Rosacea is a chronic inflammatory disease with transient and non-transient redness as key characteristics. Brimonidine is a selective α2-adrenergic receptor (AR) agonist approved for persistent facial erythema of rosacea based on significant efficacy and good safety data. The majority of patients treated with brimonidine report a benefit; however, there have been sporadic reports of worsening erythema after the initial response. A group of dermatologists, receptor physiology, and neuroimmunology scientists met to explore potential mechanisms contributing to side effects as well as differences in efficacy. We propose the following could contribute to erythema after application: (1) local inflammation and perivascular inflammatory cells with abnormally functioning ARs may lead to vasodilatation; (2) abnormal saturation and cells expressing different AR subtypes with varying ligand affinity; (3) barrier dysfunction and increased skin concentrations of brimonidine with increased actions at endothelial and presynaptic receptors, resulting in increased vasodilation; and (4) genetic predisposition and receptor polymorphism(s) leading to different smooth muscle responses. Approximately 80% of patients treated with brimonidine experience a significant improvement without erythema worsening as an adverse event. Attention to optimizing skin barrier function, setting patient expectations, and strategies to minimize potential problems may possibly reduce further the number of patients who experience side effects. Funding: Galderma International S.A.S., Paris, France