Classical Robustness of Quantum Unravellings

We introduce three measures which quantify the degree to which quantum systems possess the robustness exhibited by classical systems when subjected to continuous observation. Using these we show that for a fixed environmental interaction the level of robustness depends on the measurement strategy, or unravelling, and that no single strategy is maximally robust in all ways.Comment: 8 Pages, 2 figures, Version 2. Minor changes to wording for clarification and some references added. Accepted for publication in Europhysics Letter

Optimal states and almost optimal adaptive measurements for quantum interferometry

We derive the optimal N-photon two-mode input state for obtaining an estimate \phi of the phase difference between two arms of an interferometer. For an optimal measurement [B. C. Sanders and G. J. Milburn, Phys. Rev. Lett. 75, 2944 (1995)], it yields a variance (\Delta \phi)^2 \simeq \pi^2/N^2, compared to O(N^{-1}) or O(N^{-1/2}) for states considered by previous authors. Such a measurement cannot be realized by counting photons in the interferometer outputs. However, we introduce an adaptive measurement scheme that can be thus realized, and show that it yields a variance in \phi very close to that from an optimal measurement.Comment: 4 pages, 4 figures, journal versio

In-loop squeezing is real squeezing to an in-loop atom

Electro-optical feedback can produce an in-loop photocurrent with arbitrarily low noise. This is not regarded as evidence of `real' squeezing because squeezed light cannot be extracted from the loop using a linear beam splitter. Here I show that illuminating an atom (which is a nonlinear optical element) with `in-loop' squeezed light causes line-narrowing of one quadrature of the atom's fluorescence. This has long been regarded as an effect which can only be produced by squeezing. Experiments on atoms using in-loop squeezing should be much easier than those with conventional sources of squeezed light.Comment: 4 pages, 2 figures, submitted to PR

Entanglement-free Heisenberg-limited phase estimation

Measurement underpins all quantitative science. A key example is the measurement of optical phase, used in length metrology and many other applications. Advances in precision measurement have consistently led to important scientific discoveries. At the fundamental level, measurement precision is limited by the number N of quantum resources (such as photons) that are used. Standard measurement schemes, using each resource independently, lead to a phase uncertainty that scales as 1/sqrt(N) - known as the standard quantum limit. However, it has long been conjectured that it should be possible to achieve a precision limited only by the Heisenberg uncertainty principle, dramatically improving the scaling to 1/N. It is commonly thought that achieving this improvement requires the use of exotic quantum entangled states, such as the NOON state. These states are extremely difficult to generate. Measurement schemes with counted photons or ions have been performed with N <= 6, but few have surpassed the standard quantum limit and none have shown Heisenberg-limited scaling. Here we demonstrate experimentally a Heisenberg-limited phase estimation procedure. We replace entangled input states with multiple applications of the phase shift on unentangled single-photon states. We generalize Kitaev's phase estimation algorithm using adaptive measurement theory to achieve a standard deviation scaling at the Heisenberg limit. For the largest number of resources used (N = 378), we estimate an unknown phase with a variance more than 10 dB below the standard quantum limit; achieving this variance would require more than 4,000 resources using standard interferometry. Our results represent a drastic reduction in the complexity of achieving quantum-enhanced measurement precision.Comment: Published in Nature. This is the final versio

Squashed States of Light: Theory and Applications to Quantum Spectroscopy

Using a feedback loop it is possible to reduce the fluctuations in one quadrature of an in-loop field without increasing the fluctuations in the other. This effect has been known for a long time, and has recently been called ``squashing'' [B.C. Buchler et al., Optics Letters {\bf 24}, 259 (1999)], as opposed to the ``squeezing'' of a free field in which the conjugate fluctuations are increased. In this paper I present a general theory of squashing, including simultaneous squashing of both quadratures and simultaneous squeezing and squashing. I show that a two-level atom coupled to the in-loop light feels the effect of the fluctuations as calculated by the theory. In the ideal limit of light squeezed in one quadrature and squashed in the other, the atomic decay can be completely suppressed.Comment: 8 pages plus one figure. Submitted to JEOS-B for Dan Walls Special Issu

An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors

© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Purpose The immune checkpoint inhibitors (ICIs) have resulted in subgroups of patients with metastatic melanoma achievinghigh-quality durable responses. Metastatic melanoma survivors are a new population in the era of cancer survivorship. The aimofthis study was to evaluate metastatic melanoma survivors in terms of health-related quality of life (HRQoL), immune-relatedadverse events (irAEs) and exposure to immunosuppressive agents in a large single centre in the UK.Methods We defined the survivor population as patients with a diagnosis of metastatic melanoma who achieved a durableresponse to an ICI and had been followed-up for a minimum of 12 months from initiation of ICI without disease progression.HRQoL was assessed using SF-36. Electronic health records were accessed to collect data on demographics, treatments, irAEsand survival. HRQoL data was compared with two norm-based datasets.Results Eighty-four metastatic melanoma survivors were eligible and 87% (N = 73) completed the SF-36. ICI-related toxicity ofany grade occurred in 92%of patients and 43%had experienced a grade 3 or 4 toxicity. Almost half (49%) of the patients requiredsteroids for the treatment of ICI-related toxicity, whilst 14% required treatment with an immunosuppressive agent beyondsteroids.Melanoma survivors had statistically significant lower HRQoL scores with regard to physical, social and physical rolefunctioning and general health compared with the normative population. There was a trend towards inferior scores in patientswith previous exposure to ipilimumab compared with those never exposed to ipilimumab.Conclusions Our results show that metastatic melanoma survivors have potentially experienced significant ICI-related toxicityand experience significant impairments in specific HRQoL domains. Future service planning is required to meet this population’sunique survivorship needs.Peer reviewe

Confidence and Backaction in the Quantum Filter Equation

We study the confidence and backaction of state reconstruction based on a continuous weak measurement and the quantum filter equation. As a physical example we use the traditional model of a double quantum dot being continuously monitored by a quantum point contact. We examine the confidence of the estimate of a state constructed from the measurement record, and the effect of backaction of that measurement on that state. Finally, in the case of general measurements we show that using the relative entropy as a measure of confidence allows us to define the lower bound on the confidence as a type of quantum discord.Comment: 9 pages, 6 figure

Three-Charge Black Holes on a Circle

We study phases of five-dimensional three-charge black holes with a circle in their transverse space. In particular, when the black hole is localized on the circle we compute the corrections to the metric and corresponding thermodynamics in the limit of small mass. When taking the near-extremal limit, this gives the corrections to the constant entropy of the extremal three-charge black hole as a function of the energy above extremality. For the partial extremal limit with two charges sent to infinity and one finite we show that the first correction to the entropy is in agreement with the microscopic entropy by taking into account that the number of branes shift as a consequence of the interactions across the transverse circle. Beyond these analytical results, we also numerically obtain the entire phase of non- and near-extremal three- and two-charge black holes localized on a circle. More generally, we find in this paper a rich phase structure, including a new phase of three-charge black holes that are non-uniformly distributed on the circle. All these three-charge black hole phases are found via a map that relates them to the phases of five-dimensional neutral Kaluza-Klein black holes.Comment: 58 pages, 10 figures; v2: Corrected typos, version appearing in JHE

Matched Asymptotic Expansion for Caged Black Holes - Regularization of the Post-Newtonian Order

The "dialogue of multipoles" matched asymptotic expansion for small black holes in the presence of compact dimensions is extended to the Post-Newtonian order for arbitrary dimensions. Divergences are identified and are regularized through the matching constants, a method valid to all orders and known as Hadamard's partie finie. It is closely related to "subtraction of self-interaction" and shows similarities with the regularization of quantum field theories. The black hole's mass and tension (and the "black hole Archimedes effect") are obtained explicitly at this order, and a Newtonian derivation for the leading term in the tension is demonstrated. Implications for the phase diagram are analyzed, finding agreement with numerical results and extrapolation shows hints for Sorkin's critical dimension - a dimension where the transition turns second order.Comment: 28 pages, 5 figures. v2:published versio

Quantum Communication with Correlated Nonclassical States

Nonclassical correlations between the quadrature-phase amplitudes of two spatially separated optical beams are exploited to realize a two-channel quantum communication experiment with a high degree of immunity to interception. For this scheme, either channel alone can have an arbitrarily small signal-to-noise ratio (SNR) for transmission of a coherent ``message''. However, when the transmitted beams are combined properly upon authorized detection, the encoded message can in principle be recovered with the original SNR of the source. An experimental demonstration has achieved a 3.2 dB improvement in SNR over that possible with correlated classical sources. Extensions of the protocol to improve its security against eavesdropping are discussed.Comment: 8 pages and 4 figures (Figure 1; Figures 2a, 2b; Figure 2