Upper limits on gravitational-wave signals based on loudest events

Searches for gravitational-wave bursts have often focused on the loudest event(s) in searching for detections and in determining upper limits on astrophysical populations. Typical upper limits have been reported on event rates and event amplitudes which can then be translated into constraints on astrophysical populations. We describe the mathematical construction of such upper limits.Comment: 8 pages, 1 figur

Adiabatic Elimination in Compound Quantum Systems with Feedback

Feedback in compound quantum systems is effected by using the output from one sub-system (``the system'') to control the evolution of a second sub-system (``the ancilla'') which is reversibly coupled to the system. In the limit where the ancilla responds to fluctuations on a much shorter time scale than does the system, we show that it can be adiabatically eliminated, yielding a master equation for the system alone. This is very significant as it decreases the necessary basis size for numerical simulation and allows the effect of the ancilla to be understood more easily. We consider two types of ancilla: a two-level ancilla (e.g. a two-level atom) and an infinite-level ancilla (e.g. an optical mode). For each, we consider two forms of feedback: coherent (for which a quantum mechanical description of the feedback loop is required) and incoherent (for which a classical description is sufficient). We test the master equations we obtain using numerical simulation of the full dynamics of the compound system. For the system (a parametric oscillator) and feedback (intensity-dependent detuning) we choose, good agreement is found in the limit of heavy damping of the ancilla. We discuss the relation of our work to previous work on feedback in compound quantum systems, and also to previous work on adiabatic elimination in general.Comment: 18 pages, 12 figures including two subplots as jpeg attachment

A personalised medicine approach for ponatinib-resistant chronic myeloid leukaemia.

BACKGROUND: Chronic myeloid leukaemia (CML) is characterised by the presence of a fusion driver oncogene, BCR-ABL1, which is a constitutive tyrosine kinase. Tyrosine kinase inhibitors (TKIs) are the central treatment strategy for CML patients and have significantly improved survival rates, but the T315I mutation in the kinase domain of BCR-ABL1 confers resistance to all clinically approved TKIs, except ponatinib. However, compound mutations can mediate resistance even to ponatinib and remain a clinical challenge in CML therapy. Here, we investigated a ponatinib-resistant CML patient through whole-genome sequencing (WGS) to identify the cause of resistance and to find alternative therapeutic targets. PATIENTS AND METHODS: We carried out WGS on a ponatinib-resistant CML patient and demonstrated an effective combination therapy against the primary CML cells derived from this patient in vitro. RESULTS: Our findings demonstrate the emergence of compound mutations in the BCR-ABL1 kinase domain following ponatinib treatment, and chromosomal structural variation data predicted amplification of BCL2. The primary CD34(+) CML cells from this patient showed increased sensitivity to the combination of ponatinib and ABT-263, a BCL2 inhibitor with a negligible effect against the normal CD34(+) cells. CONCLUSION: Our results show the potential of personalised medicine approaches in TKI-resistant CML patients and provide a strategy that could improve clinical outcomes for these patients

In-loop squeezing is real squeezing to an in-loop atom

Electro-optical feedback can produce an in-loop photocurrent with arbitrarily low noise. This is not regarded as evidence of `real' squeezing because squeezed light cannot be extracted from the loop using a linear beam splitter. Here I show that illuminating an atom (which is a nonlinear optical element) with `in-loop' squeezed light causes line-narrowing of one quadrature of the atom's fluorescence. This has long been regarded as an effect which can only be produced by squeezing. Experiments on atoms using in-loop squeezing should be much easier than those with conventional sources of squeezed light.Comment: 4 pages, 2 figures, submitted to PR

Adaptive single-shot phase measurements: The full quantum theory

The phase of a single-mode field can be measured in a single-shot measurement by interfering the field with an effectively classical local oscillator of known phase. The standard technique is to have the local oscillator detuned from the system (heterodyne detection) so that it is sometimes in phase and sometimes in quadrature with the system over the course of the measurement. This enables both quadratures of the system to be measured, from which the phase can be estimated. One of us [H.M. Wiseman, Phys. Rev. Lett. 75, 4587 (1995)] has shown recently that it is possible to make a much better estimate of the phase by using an adaptive technique in which a resonant local oscillator has its phase adjusted by a feedback loop during the single-shot measurement. In Ref.~[H.M. Wiseman and R.B. Killip, Phys. Rev. A 56, 944] we presented a semiclassical analysis of a particular adaptive scheme, which yielded asymptotic results for the phase variance of strong fields. In this paper we present an exact quantum mechanical treatment. This is necessary for calculating the phase variance for fields with small photon numbers, and also for considering figures of merit other than the phase variance. Our results show that an adaptive scheme is always superior to heterodyne detection as far as the variance is concerned. However the tails of the probability distribution are surprisingly high for this adaptive measurement, so that it does not always result in a smaller probability of error in phase-based optical communication.Comment: 17 pages, LaTeX, 8 figures (concatenated), Submitted to Phys. Rev.

Entanglement distribution by an arbitrarily inept delivery service

We consider the scenario where a company C manufactures in bulk pure entangled pairs of particles, each pair intended for a distinct pair of distant customers. Unfortunately, its delivery service is inept - the probability that any given customer pair receives its intended particles is S, and the customers cannot detect whether an error has occurred. Remarkably, no matter how small S is, it is still possible for C to distribute entanglement by starting with non-maximally entangled pairs. We determine the maximum entanglement distributable for a given S, and also determine the ability of the parties to perform nonlocal tasks with the qubits they receive.Comment: 5 pages, 3 figures. v2 includes minor change

The Uncertainty Relation in "Which-Way" Experiments: How to Observe Directly the Momentum Transfer using Weak Values

A which-way measurement destroys the twin-slit interference pattern. Bohr argued that distinguishing between two slits a distance s apart gives the particle a random momentum transfer \wp of order h/s. This was accepted for more than 60 years, until Scully, Englert and Walther (SEW) proposed a which-way scheme that, they claimed, entailed no momentum transfer. Storey, Tan, Collett and Walls (STCW) in turn proved a theorem that, they claimed, showed that Bohr was right. This work reviews and extends a recent proposal [Wiseman, Phys. Lett. A 311, 285 (2003)] to resolve the issue using a weak-valued probability distribution for momentum transfer, P_wv(\wp). We show that P_wv(\wp) must be wider than h/6s. However, its moments can still be zero because P_wv(\wp) is not necessarily positive definite. Nevertheless, it is measurable in a way understandable to a classical physicist. We introduce a new measure of spread for P_wv(\wp): half of the unit-confidence interval, and conjecture that it is never less than h/4s. For an idealized example with infinitely narrow slits, the moments of P_wv(\wp) and of the momentum distributions are undefined unless a process of apodization is used. We show that by considering successively smoother initial wave functions, successively more moments of both P_wv(\wp) and the momentum distributions become defined. For this example the moments of P_wv(\wp) are zero, and these are equal to the changes in the moments of the momentum distribution. We prove that this relation holds for schemes in which the moments of P_wv(\wp) are non-zero, but only for the first two moments. We also compare these moments to those of two other momentum-transfer distributions and \hat{p}_f-\hat{p}_i. We find agreement between all of these, but again only for the first two moments.Comment: 14 pages, 6 figures, submitted to J. Opt.

Multiple-copy state discrimination: Thinking globally, acting locally

We theoretically investigate schemes to discriminate between two nonorthogonal quantum states given multiple copies. We consider a number of state discrimination schemes as applied to nonorthogonal, mixed states of a qubit. In particular, we examine the difference that local and global optimization of local measurements makes to the probability of obtaining an erroneous result, in the regime of finite numbers of copies $N$, and in the asymptotic limit as $N \rightarrow \infty$. Five schemes are considered: optimal collective measurements over all copies, locally optimal local measurements in a fixed single-qubit measurement basis, globally optimal fixed local measurements, locally optimal adaptive local measurements, and globally optimal adaptive local measurements. Here, adaptive measurements are those for which the measurement basis can depend on prior measurement results. For each of these measurement schemes we determine the probability of error (for finite $N$) and scaling of this error in the asymptotic limit. In the asymptotic limit, adaptive schemes have no advantage over the optimal fixed local scheme, and except for states with less than 2% mixture, the most naive scheme (locally optimal fixed local measurements) is as good as any noncollective scheme. For finite $N$, however, the most sophisticated local scheme (globally optimal adaptive local measurements) is better than any other noncollective scheme, for any degree of mixture.Comment: 11 pages, 14 figure