120 research outputs found

    Paraklinische Untersuchungsergebnisse unter Enzymersatztherapie bei Morbus Pompe im Erwachsenenalter

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    Paraklinische Untersuchungsergebnisse unter Enzymersatztherapie bei Morbus Pompe im Erwachsenenalter

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    Hitlers Authentizität

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    Die Sensationssuche rund um die kritische Edition von „Mein Kampf“ ebbt ab, die wissenschaftliche Auseinandersetzung kann beginnen. Andreas Wirsching macht einen inspirierenden Anfang. Angeregt durch neuere Beiträge der Hitlerforschung und aktuelle Fragen nach historischer Authentizität untersucht er das in „Mein Kampf“ präsentierte Selbstbild des „Führers“ der NSDAP und arbeitet verschiedene Schichten heraus. Hitlers politische Identität, so lautet die Kernthese, war, anders als sein Berufswunsch „Baumeister“, nicht das Resultat einer längeren, schlüssigen Entwicklung, sondern vor allem den Umständen geschuldet, in denen er sich am Kriegsende wiederfand. Aus der funktionalistischen Deutung von Hitlers politischer Biografie ergeben sich weitere Überlegungen zur Interpretation des NS-Regimes und seiner Tätermotivationen.The point of departure of this article is the concept of authenticity, which has increasingly gained importance for the construction of Bourgeois individual identity since the second half of the 19th century. The question regarding which elements of a personality can be seen as authentic, i.e. as real and credible, has also been raised about Adolf Hitler. It is thus an essential facet of the history of his ascent, which of his characteristics and biographical experiences he himself viewed or constructed as authentic and which were attributed to him as such by his environment. This encompasses aspects of Hitler's youth and his time in Vienna and Munich, as well as the question, when and under what conditions the foundations of his racist “world view” were laid. The article argues, that, in Hitler's case, a number of layers of authenticity have to be distinguished, whereby the wish to become an artist or architect plays a prominent role. His world view, which Hitler labels as authentic in “Mein Kampf”, is conversely a dimension which was added later. This emphasises the functional character of Hitler's political-ideological conditioning, which also influences the overall interpretation of the Nazi regime and the motivations of its perpetrators

    Erinnerung an Diktatur und Krieg. Brennpunkte des kulturellen Gedächtnisses zwischen Russland und Deutschland seit 1945

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    Dictatorship and war unite but also divide historical commemoration in Russia and Germany. Twenty-nine German and Russian authors examine key issues in Russian and German cultures of remembrance and their traumatic dimensions. The book includes classical memorial sites such as Stalingrad, memorials for particular groups, problematic historical sites, and the cinematic engagement with contemporary history

    Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study

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    Purpose: Adequate patient allocation is pivotal for optimal resource management in strained healthcare systems, and requires detailed knowledge of clinical and virological disease trajectories. The purpose of this work was to identify risk factors associated with need for invasive mechanical ventilation (IMV), to analyse viral kinetics in patients with and without IMV and to provide a comprehensive description of clinical course. Methods: A cohort of 168 hospitalised adult COVID-19 patients enrolled in a prospective observational study at a large European tertiary care centre was analysed. Results: Forty-four per cent (71/161) of patients required invasive mechanical ventilation (IMV). Shorter duration of symptoms before admission (aOR 1.22 per day less, 95% CI 1.10-1.37, p < 0.01) and history of hypertension (aOR 5.55, 95% CI 2.00-16.82, p < 0.01) were associated with need for IMV. Patients on IMV had higher maximal concentrations, slower decline rates, and longer shedding of SARS-CoV-2 than non-IMV patients (33 days, IQR 26-46.75, vs 18 days, IQR 16-46.75, respectively, p < 0.01). Median duration of hospitalisation was 9 days (IQR 6-15.5) for non-IMV and 49.5 days (IQR 36.8-82.5) for IMV patients. Conclusions: Our results indicate a short duration of symptoms before admission as a risk factor for severe disease that merits further investigation and different viral load kinetics in severely affected patients. Median duration of hospitalisation of IMV patients was longer than described for acute respiratory distress syndrome unrelated to COVID-19

    A time-resolved proteomic and prognostic map of COVID-19

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    COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts and enzyme activities, as well as untargeted plasma proteomes at 687 sampling points. We report an initial spike in a systemic inflammatory response, which is gradually alleviated and followed by a protein signature indicative of tissue repair, metabolic reconstitution, and immunomodulation. We identify prognostic marker signatures for devising risk-adapted treatment strategies and use machine learning to classify therapeutic needs. We show that the machine learning models based on the proteome are transferable to an independent cohort. Our study presents a map linking routinely used clinical diagnostic parameters to plasma proteomes and their dynamics in an infectious disease

    Die letzte "Ruhe des Nordens"

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    Die letzte "Ruhe des Nordens" : Preußens Neutralitätspolitik und die Beziehungen zu Frankreich 1795-1806. - In: Geschichtswissenschaft und Zeiterkenntnis : Festschrift zum 65. Geburtstag von Horst Möller / hrsg. von Klaus Hildebrand ... - München : Oldenbourg, 2008. - S. 67-8

    Die deutsche "Mehrheitsgesellschaft" und die Etablierung des NS-Regimes im Jahre 1933

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    Die deutsche "Mehrheitsgesellschaft" und die Etablierung des NS-Regimes im Jahre 1933. - In: Das Jahr 1933 / hrsg. von Andreas Wirsching. - Göttingen : Wallstein, 2009. - S. 9-29. - (Dachauer Symposien zur Zeitgeschichte ; 9
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