Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes

The bacterial pathogen Helicobacter pylori commonly colonizes the human gastric mucosa during early childhood and persists throughout life. The organism has evolved multiple mechanisms for evading clearance by the immune system and, despite inducing inflammation in the stomach, the majority of infections are asymptomatic. H. pylori is the leading cause of peptic ulcer disease and gastric cancer. However, disease outcomes are related to the pattern and severity of chronic inflammation in the gastric mucosa, which in turn is influenced by both bacterial and host factors. Despite over 2 decades of intensive research, there remains an incomplete understanding of the circumstances leading to disease development, due to the fascinating complexity of the host-pathogen interactions. There is accumulating data concerning the virulence factors associated with increased risk of disease, and the majority of these have pro-inflammatory activities. Despite this, only a small proportion of those infected with virulent strains develop disease. Several H. pylori virulence factors have multiple effects on different cell types, including the induction of pro- and anti-inflammatory, immune stimulatory, and immune modulatory responses. The expression of multiple virulence factors is also often linked, making it difficult to assess the meaning of their effects in isolation. Overall, H. pylori is thought to usually modulate inflammation and limit acute damage to the mucosa, enabling the bacteria to persist. If this delicate balance is disturbed, disease may then develop

Effects of interstellar particles upon the interplanetary magnetic field

The flow of interstellar neutral particles into the interplanetary medium and their subsequent ionization in the presence of the electromagnetic field of the solar wind can cause a loss of field angular momentum by the solar wind. One effect of this loss of field angular momentum is a significant unwinding of the spiral field. This effect is evaluated using simple models for neutral density and ion production. For a free-stream interstellar medium with a neutral hydrogen density of 1 per cubic centimeter and a velocity relative to the sun of 10 to 20 km per second, the spiral angle at the orbit of Jupiter will be less than its nominal value of 45 deg at the orbit of the earth

Pb-Zn liquid metal diffusion

The Lead-Zinc binary equilibrium system is currently being investigated. Ground based studies of this system were performed to examine the possibility of obtaining a couple which, after diffusion, could be examined continuously along the diffusion axis by quantitative metallography to determine the extent of diffusion. The specimens were analyzed by X-ray fluorescence in the scanning electron microscope to provide exact information on the chemical composition gradient. Two diffusion experiments were run simultaneously in the multipurpose furnace, each in its own isothermal cavity. Two flight samples, two flight backup samples, and two flight space samples were generated

Labor Injunctions and Judge-Made Labor Law: The Contemporary Role of Norris-LaGuardia

Substantial changes in federal labor policy since the passage of the Norris-LaGuardia Act in 1932 cast doubt upon the continued vitality of thatstatute and its underlying policies

Changing Concepts of Equality: From Equality Before the Law to the Welfare State

Equality, or at least the rhetoric of equality, has been almost from the start a central issue in our society. The debate, however, has been a fluid one, because the society has shifted from the pursuit of one concept of equality to the pursuit of another. The former concept of equality I shall call equality before the law. The latter I shall call equality of social-political-economic status

The New Age of Political Reform: Looking Back

To summarize, the impact of the new age of political reformhas been wider and deeper than that of the Progressive Era andhas led to defeated expectations and unwanted consequences that would have astonished even so skeptical an observer as AlexBickel. It has impacted upon our political parties with a destructivenessthat even now is difficult to comprehend