1,216 research outputs found
Successful long-term monotherapy with rituximab in a patient with chronic lymphocytic leukemia of the B-cell-lineage: a case report
<p>Abstract</p> <p>Introduction</p> <p>Treatment of chronic lymphocytic leukemia of the B-cell-lineage is strongly based upon clinical staging because of the heterogeneous clinical course of this disease.</p> <p>Case presentation</p> <p>We describe a 62-year-old patient with newly diagnosed chronic lymphocytic leukemia of the B-cell-lineage who did not respond to several chemotherapy regimens including chlorambucil, fludarabine and cyclophosphamide, developing a marked neutropenia and thrombocytopenia with life-threatening infections. Further chemotherapy appeared not feasible because of bone marrow toxicity. The patient was treated with 600 mg/m<sup>2 </sup>rituximab weekly followed by eight courses of biweekly therapy and then by long-term maintenance therapy, achieving almost complete remission of the symptoms and disease control.</p> <p>Conclusion</p> <p>After resistance to standard chemotherapy with chlorambucil and fludarabine, a patient with chronic lymphocytic leukemia of the B-cell-lineage was successfully treated with rituximab.</p
Repulsively bound atom pairs in an optical lattice
Throughout physics, stable composite objects are usually formed via
attractive forces, which allow the constituents to lower their energy by
binding together. Repulsive forces separate particles in free space. However,
in a structured environment such as a periodic potential and in the absence of
dissipation, stable composite objects can exist even for repulsive
interactions. Here we report on the first observation of such an exotic bound
state, comprised of a pair of ultracold atoms in an optical lattice. Consistent
with our theoretical analysis, these repulsively bound pairs exhibit long
lifetimes, even under collisions with one another. Signatures of the pairs are
also recognised in the characteristic momentum distribution and through
spectroscopic measurements. There is no analogue in traditional condensed
matter systems of such repulsively bound pairs, due to the presence of strong
decay channels. These results exemplify on a new level the strong
correspondence between the optical lattice physics of ultracold bosonic atoms
and the Bose-Hubbard model, a correspondence which is vital for future
applications of these systems to the study of strongly correlated condensed
matter systems and to quantum information.Comment: 5 pages, 4 figure
Non-Abelian statistics and topological quantum information processing in 1D wire networks
Topological quantum computation provides an elegant way around decoherence,
as one encodes quantum information in a non-local fashion that the environment
finds difficult to corrupt. Here we establish that one of the key
operations---braiding of non-Abelian anyons---can be implemented in
one-dimensional semiconductor wire networks. Previous work [Lutchyn et al.,
arXiv:1002.4033 and Oreg et al., arXiv:1003.1145] provided a recipe for driving
semiconducting wires into a topological phase supporting long-sought particles
known as Majorana fermions that can store topologically protected quantum
information. Majorana fermions in this setting can be transported, created, and
fused by applying locally tunable gates to the wire. More importantly, we show
that networks of such wires allow braiding of Majorana fermions and that they
exhibit non-Abelian statistics like vortices in a p+ip superconductor. We
propose experimental setups that enable the Majorana fusion rules to be probed,
along with networks that allow for efficient exchange of arbitrary numbers of
Majorana fermions. This work paves a new path forward in topological quantum
computation that benefits from physical transparency and experimental realism.Comment: 6 pages + 17 pages of Supp. Mat.; 10 figures. Supp. Mat. has doubled
in size to establish results more rigorously; many other improvements as wel
Ultracold dense gas of deeply bound heteronuclear molecules
Recently, the quest for an ultracold and dense ensemble of polar molecules
has attracted strong interest. Polar molecules have bright prospects for novel
quantum gases with long-range and anisotropic interactions, for quantum
information science, and for precision measurements. However, high-density
clouds of ultracold polar molecules have so far not been produced. Here, we
report a key step towards this goal. Starting from an ultracold dense gas of
heteronuclear 40K-87Rb Feshbach molecules with typical binding energies of a
few hundred kHz and a negligible dipole moment, we coherently transfer these
molecules into a vibrational level of the ground-state molecular potential
bound by >10 GHz. We thereby increase the binding energy and the expected
dipole moment of the 40K-87Rb molecules by more than four orders of magnitude
in a single transfer step. Starting with a single initial state prepared with
Feshbach association, we achieve a transfer efficiency of 84%. While dipolar
effects are not yet observable, the presented technique can be extended to
access much more deeply bound vibrational levels and ultimately those
exhibiting a significant dipole moment. The preparation of an ultracold quantum
gas of polar molecules might therefore come within experimental reach.Comment: 5 pages, 5 figure
Thermodynamics of mixing in diopside-jadeite, CaMgSi2O6-NaAlSi2O6, solid solution from staticlattice energy calculations
Static lattice energy calculations (SLEC), based on empirical interatomic potentials, have beenperformed for a set of 800 different structures in a 2 2 4 supercell of C2/c diopside with compositionsbetween diopside and jadeite, and with different states of order of the exchangeable Na/Ca and Mg/Al cations. Excess static energies of these structures have been cluster expanded in a basis set of 37 pair-interaction parameters. These parameters have been used to constrain Monte Carlo simulations of temperature-dependent properties in the range of 273?2,023 K and to calculate a temperature?composition phase diagram. The simulations predict the order?disorder transition in omphacite at1,150 20C in good agreement with the experimental data of Carpenter (Mineral Petrol 78:433?440, 1981). The stronger ordering of Mg/Al within the M1 site than of Ca/Na in the M2 site is attributed to the shorter M1?M1 nearest-neighbor distance, and, consequently, the stronger ordering force. The comparison of the simulated relationship between the order parameters corresponding to M1 and M2 sites with the X-ray refinement data on natural omphacites (Boffa Ballaran et al. in Am Mineral83:419?433, 1998) suggests that the cation ordering becomes kinetically ineffective at about 600C
Correlation between nucleotide composition and folding energy of coding sequences with special attention to wobble bases
Background: The secondary structure and complexity of mRNA influences its
accessibility to regulatory molecules (proteins, micro-RNAs), its stability and
its level of expression. The mobile elements of the RNA sequence, the wobble
bases, are expected to regulate the formation of structures encompassing coding
sequences.
Results: The sequence/folding energy (FE) relationship was studied by
statistical, bioinformatic methods in 90 CDS containing 26,370 codons. I found
that the FE (dG) associated with coding sequences is significant and negative
(407 kcal/1000 bases, mean +/- S.E.M.) indicating that these sequences are able
to form structures. However, the FE has only a small free component, less than
10% of the total. The contribution of the 1st and 3rd codon bases to the FE is
larger than the contribution of the 2nd (central) bases. It is possible to
achieve a ~ 4-fold change in FE by altering the wobble bases in synonymous
codons. The sequence/FE relationship can be described with a simple algorithm,
and the total FE can be predicted solely from the sequence composition of the
nucleic acid. The contributions of different synonymous codons to the FE are
additive and one codon cannot replace another. The accumulated contributions of
synonymous codons of an amino acid to the total folding energy of an mRNA is
strongly correlated to the relative amount of that amino acid in the translated
protein.
Conclusion: Synonymous codons are not interchangable with regard to their
role in determining the mRNA FE and the relative amounts of amino acids in the
translated protein, even if they are indistinguishable in respect of amino acid
coding.Comment: 14 pages including 6 figures and 1 tabl
Associations of sitting accumulation patterns with cardio-metabolic risk biomarkers in Australian adults
Backgroun
Statins but not fibrates improve the atherogenic to anti-atherogenic lipoprotein particle ratio: a randomized crossover study
Computational Lipidology: Predicting Lipoprotein Density Profiles in Human Blood Plasma
Monitoring cholesterol levels is strongly recommended to identify patients at risk for myocardial infarction. However, clinical markers beyond “bad” and “good” cholesterol are needed to precisely predict individual lipid disorders. Our work contributes to this aim by bringing together experiment and theory. We developed a novel computer-based model of the human plasma lipoprotein metabolism in order to simulate the blood lipid levels in high resolution. Instead of focusing on a few conventionally used predefined lipoprotein density classes (LDL, HDL), we consider the entire protein and lipid composition spectrum of individual lipoprotein complexes. Subsequently, their distribution over density (which equals the lipoprotein profile) is calculated. As our main results, we (i) successfully reproduced clinically measured lipoprotein profiles of healthy subjects; (ii) assigned lipoproteins to narrow density classes, named high-resolution density sub-fractions (hrDS), revealing heterogeneous lipoprotein distributions within the major lipoprotein classes; and (iii) present model-based predictions of changes in the lipoprotein distribution elicited by disorders in underlying molecular processes. In its present state, the model offers a platform for many future applications aimed at understanding the reasons for inter-individual variability, identifying new sub-fractions of potential clinical relevance and a patient-oriented diagnosis of the potential molecular causes for individual dyslipidemia
- …