563 research outputs found
Effects of Partnerships between Adolescents with Developmental Disabilities and Service Dogs
Background: With increasing frequency, service dogs are being placed with children with developmental disabilities (DDs). Occupational therapists and other professionals have advocated for the therapeutic use of service dog partnerships to facilitate greater independence and quality of life. There are no studies that examine service dog intervention with adolescents.
Method: This study focused on the effects of partnerships between service dogs and three participant dyads, each including an adolescent with DDs and a parent. A single-subject, alternating treatment design was used to compare the effects of two conditions (service dog present or not present). The effects were examined for adolescents’ anxiety behaviors during transitions and during grocery store shopping, for social interactions during grocery store shopping, and for parents’ reported levels of stress.
Results: Findings were that service dog partnerships reduced the presence of anxiety behaviors during transitions for one of the three adolescents; reduced the presence of anxiety behaviors during grocery store visits for two of the three adolescents; increased social interactions for all three of the participant dyads; and had no meaningful impact on self-reported parental stress level.
Conclusion: For adolescents with DDs, professionals may want to consider service dog partnerships to decrease anxiety behaviors and increase social interactions in the community
A twist in chiral interaction between biological helices
Using an exact solution for the pair interaction potential, we show that
long, rigid, chiral molecules with helical surface charge patterns have a
preferential interaxial angle ~((RH)^1/2)/L, where L is the length of the
molecules, R is the closest distance between their axes, and H is the helical
pitch. Estimates based on this formula suggest a solution for the puzzle of
small interaxial angles in a-helix bundles and in cholesteric phases of DNA.Comment: 7 pages, 2 figures, PDF file onl
LHC Beam Diffusion Dependence on RF Noise: Models and Measurements
Radio Frequency (RF) accelerating system noise and non-idealities can have detrimental impact on the LHC performance through longitudinal motion and longitudinal emittance growth. A theoretical formalism has been developed to relate the beam and RF loop dynamics with the bunch length growth [1]. Measurements were conducted at LHC to validate the formalism, determine the performance limiting RF components, and provide the foundation for beam diffusion estimates for higher energies and intensities. A brief summary of these results is presented in this work
The Cytotoxicity and Mode of Action of 2,3,4-Trisubstituted Pyrroles and Related Derivatives in Human Tmolt4 Leukemia Cells
4-Carbechoxy-l-methyl-2-phenacyl-3-phenylpyrrole (9), 4-carbethoxy-2-(4-methoxybcnzoyl)-3-(4-methoxyphcnyl)pyrrole (10) and 2-(4-methoxybenzoyl)-3,4-bis-(4-methoxyphenyl)pyrrole (11) proved to be potent cytotoxic agents against the growth of murine and human leukemias and lymphomas. Selective toxicity was demonstrated against the growth of solid tumors, e.g. human adenocarcinoma of the colon SW480 and ileum HCT-8, glioma U-87-MG, and rat UMR-106 osteosarcoma. A mode of action study in Tmolt4 leukemia cells demonstrated that the agents inhibited de novo purine synthesis at the regulatory sites PRPP-amido transferase, IMP dehydrogenase as well as dihydrofolate reductase resulting in significant inhibition of DNA synthesis in 60 min. Other biochemical sites which were affected significantly were thymidylate synthetase, DNA polymerase a, RNA polymerases, nucleoside kinase and ribonucleoside reductase
Buckling Instabilities of a Confined Colloid Crystal Layer
A model predicting the structure of repulsive, spherically symmetric,
monodisperse particles confined between two walls is presented. We study the
buckling transition of a single flat layer as the double layer state develops.
Experimental realizations of this model are suspensions of stabilized colloidal
particles squeezed between glass plates. By expanding the thermodynamic
potential about a flat state of confined colloidal particles, we derive
a free energy as a functional of in-plane and out-of-plane displacements. The
wavevectors of these first buckling instabilities correspond to three different
ordered structures. Landau theory predicts that the symmetry of these phases
allows for second order phase transitions. This possibility exists even in the
presence of gravity or plate asymmetry. These transitions lead to critical
behavior and phases with the symmetry of the three-state and four-state Potts
models, the X-Y model with 6-fold anisotropy, and the Heisenberg model with
cubic interactions. Experimental detection of these structures is discussed.Comment: 24 pages, 8 figures on request. EF508
Measuring Cosmic Defect Correlations in Liquid Crystals
From the theory of topological defect formation proposed for the early
universe, the so called Kibble mechanism, it follows that the density
correlation functions of defects and anti-defects in a given system should be
completely determined in terms of a single length scale , the relevant
domain size. Thus, when lengths are expressed in units of , these
distributions should show universal behavior, depending only on the symmetry of
the order parameter, and space dimensions. We have verified this prediction by
analyzing the distributions of defects/anti-defects formed in the
isotropic-nematic phase transition in a thin layer of nematic liquid crystals.
Our experimental results confirm this prediction and are in reasonable
agreement with the results of numerical simulations.Comment: 15 pages, 4 figures, minor changes, few new references adde
Defects in Chiral Columnar Phases: Tilt Grain Boundaries and Iterated Moire Maps
Biomolecules are often very long with a definite chirality. DNA, xanthan and
poly-gamma-benzyl-glutamate (PBLG) can all form columnar crystalline phases.
The chirality, however, competes with the tendency for crystalline order. For
chiral polymers, there are two sorts of chirality: the first describes the
usual cholesteric-like twist of the local director around a pitch axis, while
the second favors the rotation of the local bond-orientational order and leads
to a braiding of the polymers along an average direction. In the former case
chirality can be manifested in a tilt grain boundary phase (TGB) analogous to
the Renn-Lubensky phase of smectic-A liquid crystals. In the latter case we are
led to a new "moire" state with twisted bond order. In the moire state polymers
are simultaneously entangled, crystalline, and aligned, on average, in a common
direction. In the moire state polymers are simultaneously entangled,
crystalline, and aligned, on average, in a common direction. In this case the
polymer trajectories in the plane perpendicular to their average direction are
described by iterated moire maps of remarkable complexity, reminiscent of
dynamical systems.Comment: plain TeX, (33 pages), 17 figures, some uufiled and included, the
remaining available at ftp://ftp.sns.ias.edu/pub/kamien/ or by request to
[email protected]
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