Efek Pemberian Air Embun terhadap Gambaran Hematologi dan Biokimia Darah

Circulation disorder of blood at a person is related to metabolic process, and it can not be as the normal equilibirum, and later can affect to appearance of disseases. Dew water, can be produced from destilation process (Systemized Dew Process), filtered process and disinfection with ozoniation. Dew water is stated can be used for disorder of blood circulation treatment. For the examination effect of dew water for blood circulation disorder, dew water was tested for blood description and biochemistry blood description at the animal model with cholesterol diet.It was the experimental pharmacology method, with the blood description as hamoglobline, erythrocyte, leucocyte, thrombocyte, hematochrite value; biochemistry description as total cholesterol, LDL cholesterol, HDL cholesterol, trigliserid; freeze time of blood; the arteri thickness ; body weight and the volume of intake water. Base on the normally of dosage at human, dew water intake for animal model were all day long admintration and of all of research time, every day for 2 month. The result of research has shown decrease of the body weight; increase need for intake water ; repairing haematology and biochemistry of blood, escpecially decrease of total cholesterol and LDL cholesterol; diluting blood; decreasing ateroschlerosis disorder at arteri vesse

Efek Ekstrak Campuran Kulit Batang Pulai (Alstonia scholaris) dan Meniran (Phyllanthus niruri) pada Mencit Swiss Webster yang Diinfeksi Plasmodium berghei

Pulai and meniran is one of the medicinal plants that have been studied as a possible antimalarial drugs. This study aims to evaluate the antimalarial activity of a mixture of pulai bark and meniran extracts as antimalarial drugs. Acute toxicity tests was performed using male and female Wistar rats each 25 animals with four doses of treatment. Antimalarial test using 72 mice were divided into six dose groups: group CMC, DHP, dose mixture of 1330; 443.34; 147.78 mg/kg bw and doses of pulai groups 1330 mg /kg bw. All the mice were infected with Plasmodium berghei (D0) and given the extracts orally for 14 days. Giemsa blood stainning taken on days D1-D7 and D14 were analyzed for percentage of parasitaemia, lymphocytes, monocytes and granulocytes. Results of acute toxicity test (LD50) values obtained from extract mixture was more than 14285 mg/kg bw, are classified as non-toxic materials. The most effective dose of the test antimalarial obtained from the percentage of parasites reducing and leukocytes differential, was 147.78 mg/kg. A mixture of pulai bark and meniran extract can be considered to be used as an alternative drug in the treatment of malaria. Further research is needed to isolate and characterized the active ingredients which have the effect of antimalarial to be recommended as an antimalarial drug in the future

Toksisitas Akut dan Subkronis Ramuan Ekstrak Kelor dan Klabet sebagai Pelancar ASI dan Penambah Gizi

Insufficient breast milk intake from a mother to their babies may cause a poor infant growth. We have conducted a research on mixture of klabet seed extracts (Trigonella foenum-graecum L.) and kelor leaf extract (Moringa oleifera Lamk.) (1:1) for increasing breast milk production in nursing mothers and nutritional supplement for infants. The study is a completely randomized design. We used white rats (Rattus novergicus), Wistar strain, as many as 50, that were divided into 5 dose groups for the acute toxicity testing and 40 rats in 4 dose groups for the sub-chronic toxicity testing.The acute toxicity testing of fenugreek seed extracts and moringa leaf extracts (1:1) results in a pseudo value LD50 >4,000 mg/200g bw, therefore we classified the materials to practically non-toxic (PNT). For the subchronic toxicity testing, the result showed a normal state on liver and kidney function

In Vitro Anticancer Activity of Leaves Extracts from Annona muricata againts HeLa Cervical Cancer Cell Line

Cervical cancer continues to be a widespread public health problem in women worldwide especially in developing country like Indonesia. The data from thirteen pathology centers in Indonesia describes that cervical cancer stands the first-ranked among all cancer. The soursop (Annona muricata) is a traditional medicinal plant which is empirically used by the people of Indonesia for anti-inflammation and anti-tumor. This study aims to determine the cytotoxic effects from extracts of leaves of soursop in cervical cancer cells HeLa. Method: The research was carried out by extraction using ethanol and water. Cytotoxic test performed by the method of MTT assay. The parameters obtained from the cytotoxic test was IC50 values, ie concentrations that produce inhibitory of cancer cells by 50%. Result: The results showed that the ethanol extracts of soursop leaves has a cytotoxic activity with IC50 values of 1,787μg / mL, while aquos extracts the leaves has cytotoxic activity with IC50 values of 1,781 μg / mL. All that values is better than that obtained from 5-Fluorouracil with IC50 values of 1,82 μg/mL

Pengaruh Pemberian Kombinasi Ekstrak Rumput Mutiara (Hedyotis corymbosa Lamk) dan Meniran (Phyllanthus Niruri L.) terhadap Jumlah AgNOR Jaringan Adenokarsinoma Mammae Mencit C3H

Cancer is one of the non-communicable diseases that has become a health problem in the world, including in Indonesia. Data World Health Organization (WHO) data in 2010 showed that cancer is the second leading cause of death after cardiovascular disease. Mean while, result at Basic Health Research Riset Kesehatan Dasar (Riskesdas) 2007 showed that cancer ranks sixth in the leading cause of death in Indonesia. Number of cancer patients in Indonesia continues to increase and is expected to be the main cause of the increasing economic burden, for the patient, family, and also country. Types of cancer in Indonesia is dominated by breast cancer (30%) cervical cancer (24%). This study aims to determine the effect of a combination of rumput mutiara (Hedyotis corymbosa Lamk) and meniran (Phyllanthus niruri L) against mammary adenocarcinoma in strain C3H mice. This study is an experimental study. The study sample consisted of 20 strains of C3H mice that were divided into 4 groups: control group (K) and three dose groups ( P1 - P3 ), namely : dose 750 ; 1500; 2250 mg/kg BW. Extract of the test material were given after the tumor is palpable, It was given to the mice for 19 days, once a day orally using a stomach sonde. The results of this study indicate that based on the average number of AgNOR mammary adenocarcinoma, the extract at a dose of 2250 mg/kg BW can reduce the proliferation of mammary tumor cells

EFEK LAKSATIF JUS DAUN ASAM JAWA (Tamarindus indica Linn.) PADA TIKUS PUTIH YANG DIINDUKSI DENGAN GAMBIR

Plants tamarind (Tamarindus indica Linn.) known to the public as a shade tree and is found in almost all parts of Indonesia. The leaves are called "sinom" in the Java language is also used as a vegetable and medicine Empirically Java acid is used as a remedy gout, ulcers, boils, laxative, fever, menstrual facilitator, inflammation. Laxative effect has been studied (laxative) leaf juice tamarind (Tamarindus indica Linn.) Intestinal transit method and experimental animals used white rats. The dose tested was 3 doses of juice that is 20%, 40% and 60%, which is given orally. For purposes of comparison (positive control) is the granting of four Dulcolax ml/200 g bw., While distilled water as negative control. Two days before the experiment is done, all rats were induced constipation with gambier extract 3 g / kg bw. The experimental results showed that the average ratio of intestinal length traversed by charcoal proanalisa Java acidic juice dose group 60%, 40%, 20%; Dulcolax and distilled water, respectively 49.86%, 60.2%, 18.34%, 75.22% and 2.01%. Showed statistically tamarind juice at doses of 40% has laxative properties, but smaller than the Dulcolax.   Keywords: laxative, white mice, Tamarindus indica Linn., leaves, tamarindjuic

UJI TOKSISITAS SUB KRONIK EKSTRAK DAUN KEMBANG SUNGSANG (Gloriosa superba L.) TERHADAP FUNGSI GINJAL TIKUS PUTIH

Abstract. Kembang sungsang (Gloriosa superba L.) including families Colchicaceae, empirically this plant can be used to treat gout, diuretic, rheumatic and cultivated because of its use. All parts of this plant contain alkaloids called colchichin and gloriosin and most found on the tuber. From the results of previous research, the ethanol extract of leaves and flowers antihiperurisemia Breech is included in the class materials "Practically Non-Toxic." However, repeated administration may cause toxic effects on body organs. Test the effect of 70% ethanol extract of kembang sungsang leaves of kidney function in male and female white rats. There are 3 (three) doses of test materials which are: 32.25 mg, 21.5 mg and 14.35 mg/100 g bw., And as a control was distilled water. Test and control material was administered orally in accordance with a predetermined time is 45 days, 90 days and 104 days (recovery period for the largest dose) administration. Observation is done by sacrificing mice according to given deadlines. Results of blood biochemistry analysis showed that drug therapy for 45 days, to increase blood urea and creatinine, but the award of 90 and 104 days (recovery) decreased creatinine levels.Keywords: Toxicity, Kembang Sungsang, Gloriosa superba L. Kidney functio

Efek Daun Dewa (Gynura pseudo-china Aug D.C.) terhadap Peningkatan Trombosit Tikus Putih yang Diinduksi Hidroksi Urea

Daun dewa (Gynura pseudo-china Aug. DC), empirically used as anti-inflammation, anti­ diare, anti-tumor, and anti-fungus Additionally, it also used to prevent blood vessel contriction, and stimulate the immune system. The leaf from Daun Dewa empirically used to dengue fever treatment. In this study, 25 white rats Wistar strain were used which is divided into 5 groups : 1) control group, 2) study group, which is divedid into 3 doses (100 mg, 200 mg, 400 mg/200g body weight) and 3) the normal control group (without induced). Hydroxy urea dose 27 mg/200 g body weight 2 times a day for induced The treatment given 8 days dividing and every 2 days once done taking 0,5 ml of blood via the tail vein. Result showed ethanol leaf extract of Daun dewa dose 100 mg,200 mg, and 400 mg/ 200 g body weight increase thrombocyte. Incease thrombocyte going on forth day after the test dose, and the sixth day amount thrombocyte have reached normal.   Keywords: Daun dewa (Gynura pseudo-china Aug. DC), ethanol extract, thrombocyte</p

Efek Daun Dewa (Gynura pseudo-china Aug D.C.) terhadap Peningkatan Trombosit Tikus Putih yang Diinduksi Hidroksi Urea

Daun dewa (Gynura pseudo-china Aug. DC), empirically used as anti-inflammation, anti-diare, anti-tumor, and anti-fungus Additionally, it also used to prevent blood vessel contriction, and stimulate the immune system. The leaf flom Daun Dewa empirically used to dengue fever treatment. In this study, 25 white rats Wistar strain were used which is divided into 5 groups J I) control group, 2) study group, which is divedid into 3 doses (100 mg, 200 mg, 400 mg/200g body weight) and 3) the normal control group (without induced). Hydroxy urea dose 27 mg/200 g body weight 2 times a day for induced. The treatment given 8 days dividing and every 2 days once done taking 0,5 ml of blood via the tail vein. Result showed ethanol leaf extract of Daun dewa dose 100 mg, 200 mg, and 400 mg/ 200 g body weight increase thrombocyte. Incease thrombocyte going on forth day afier the test dose, and the sixth day amount thrombocyte have reached normal

Pengaruh Pemberian Kombinasi Ekstrak Rumput Mutiara (Hedyotis corymbosa Lamk) dan Meniran (Phyllanthus Niruri L.) terhadap Jumlah AgNOR Jaringan Adenokarsinoma Mammae Mencit C3H

Cancer is one of the non-communicable diseases that has become a health problem in the world, including in Indonesia. Data World Health Organization (WHO) data in 2010 showed that cancer is the second leading cause of death after cardiovascular disease. Mean while, result at Basic Health Research Riset Kesehatan Dasar (Riskesdas) 2007 showed that cancer ranks sixth in the leading cause of death in Indonesia. Number of cancer patients in Indonesia continues to increase and is expected to be the main cause of the increasing economic burden, for the patient, family, and also country. Types of cancer in Indonesia is dominated by breast cancer (30%) cervical cancer (24%). This study aims to determine the effect of a combination of rumput mutiara (Hedyotis corymbosa Lamk) and meniran (Phyllanthus niruri L) against mammary adenocarcinoma in strain C3H mice. This study is an experimental study. The study sample consisted of 20 strains of C3H mice that were divided into 4 groups: control group (K) and three dose groups ( P1 - P3 ), namely : dose 750 ; 1500; 2250 mg/kg BW. Extract of the test material were given after the tumor is palpable, It was given to the mice for 19 days, once a day orally using a stomach sonde. The results of this study indicate that based on the average number of AgNOR mammary adenocarcinoma, the extract at a dose of 2250 mg/kg BW can reduce the proliferation of mammary tumor cells